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Substrate Report for: O-Nitrophenylacetate

Chromogenic esterase substrate


General
Type Acetate, Aryl ester, 2-nitrophenyl
Chemical_Nomenclature (2-nitrophenyl) acetate
Canonical SMILES CC(=O)OC1=CC=CC=C1[N+](=O)[O-]
InChI InChI=1S/C8H7NO4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3
InChIKey MRCKRGSNLOHYRA-UHFFFAOYSA-N
Other name(s) ONPA ; 2-Nitrophenyl acetate ; O-Nitrophenyl acetate ; Acetic acid, 2-nitrophenyl ester ; 2-Nitrophenol acetate ; Acetic acid, o-nitrophenyl ester
________________________________________________________________________________________________
MW|181.1
Formula|C8H7NO4
CAS_number|610-69-5
PubChem|11890
UniChem|MRCKRGSNLOHYRA-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | O-Nitrophenylacetate ligand of proteins in family: Carboxylesterase, Cholinesterase, Carb_B_Chordata

References:
Search PubMed for references concerning: O-Nitrophenylacetate
    Title: Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis
    Harada T, Nakagawa Y, Wadkins RM, Potter PM, Wheelock CE
    Ref: Bioorganic & Medicinal Chemistry, 17:149, 2009 : PubMed

            

    Title: Evidence for subdomain flexibility in Drosophila melanogaster acetylcholinesterase
    Stojan J, Ladurantie C, Siadat OR, Paquereau L, Fournier D
    Ref: Biochemistry, 47:5599, 2008 : PubMed

            

    Title: Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety
    Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK and Potter PM <1 more author(s)>
    Ref: Journal of Medicinal Chemistry, 48:5543, 2005 : PubMed