Derivative of Irinotecan
General
Irinotecan (CPT-11), an anticancer prodrug is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to its active metabolite SN-38 (7-ethyl-10-hydroxycamptothecin) a potent inhibitor of topoisomerase I. CPT-11 is hydrolysed by carboxylesterases in human pig and rabbit. Horse BChE hydrolyses 200 times faster CPT-11 than human BChE
| Inhibitor | Main targeted enzyme familyes | Type | Structure |
|---|---|---|---|
| 4-piperidino-piperidine | Carb_B_Chordata | Leaving group Derivative of Irinotecan Piperidine |
|
| SN-38 | Carb_B_Bacteria Carb_B_Chordata | Drug Derivative of Irinotecan Not A\/B H target Pro-Drug |
|
| Irinotecan | Carboxylesterase Carb_B_Chordata Carb_B_Bacteria | Carbamate Drug Derivative of Irinotecan Not A\/B H target |
|