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pyrethroid

The targets of pyrethroids are not Alpha\/beta hydrolases. The synthetic pyrethroids delay closure of the sodium channel, resulting in a sodium tail current that is characterized by a slow influx of sodium during the end of depolarization. Carboxylesterases are involved in elimination of Pyrethroids and mutations can enhance resistance to pyrethroids
Substrate Main targeted enzyme familyes Type Structure
Fenvalerate Carb_B_Arthropoda Carb_B_Chordata HNLyase_Bact pyrethroid Phenoxyphenyl
Esfenvalerate Carb_B_Arthropoda Carb_B_Chordata HNLyase_Bact pyrethroid Phenoxyphenyl
Cypermethrin Carb_B_Arthropoda LYsophospholipase_carboxylesterase Carb_B_Chordata 6_AlphaBeta_hydrolase pyrethroid Insecticide Phenoxyphenyl Cyclopropane Not A\/B H target Cyanide
trans-Bifenthrin HNLyase_Bact Carb_B_Arthropoda pyrethroid Insecticide Trifluoro Not A\/B H target Carbamate Cyclopropane
Fenpropathrin Carb_B_Arthropoda Cholinesterase-like pyrethroid Insecticide Acaricide Cyanide Not A\/B H target Phenoxyphenyl Cyclopropane
lambda-Cyhalothrin Carb_B_Arthropoda CarbLipBact_1 6_AlphaBeta_hydrolase HNLyase_Bact pyrethroid Insecticide Phenoxyphenyl Cyanide Cyclopropane
Deltamethrin Carboxylesterase Carb_B_Chordata Carb_B_Arthropoda Carb_B_Bacteria 6_AlphaBeta_hydrolase HNLyase_Bact pyrethroid Insecticide Phenoxyphenyl Cyanide Cyclopropane
Permethrin Carboxylesterase Carb_B_Chordata Carb_B_Arthropoda Carb_B_Bacteria pyrethroid Insecticide Drug Not A\/B H target Phenoxyphenyl Cyclopropyl