Kang KH

References (4)

Title : Observational Study of Clinical and Functional Progression Based on Initial Brain MRI Characteristics in Patients with Alzheimer's Disease - Choi_2018_J.Alzheimers.Dis_66_1721
Author(s) : Choi H , Yang Y , Han HJ , Jeong JH , Park MY , Kim YB , Jo KD , Choi JY , Kang KH , Kang H , Kwon DY , Yoo BG , Lee HJ , Shin BS , Jeon SM , Kwon OD , Kim JS , Lee SJ , Kim Y , Park TH , Kim YJ , Yang HJ , Park HY , Shin HE , Lee JS , Jung YH , Lee AY , Shin DI , Shin KJ , Park KH
Ref : J Alzheimers Dis , 66 :1721 , 2018
Abstract : BACKGROUND: Magnetic resonance imaging (MRI) is a useful tool to predict the diagnosis and progression of Alzheimer's disease (AD), especially for primary physicians. However, the correlation between baseline MRI findings and AD progression has not been fully established. OBJECTIVE: To investigate the correlation between hippocampal atrophy (HA) and white matter hyperintensities (WMH) on initial brain MRI images and the degree of cognitive decline and functional changes over 1 year. METHODS: In this prospective, 12-month observational study, dementia outpatients were recruited from 29 centers across South Korea. Baseline assessments of HA and WMH on baseline brain MRI were derived as well as cognitive function, dementia severity, activities of daily living, and acetylcholinesterase inhibitor (AChEI) use. Follow-up assessments were conducted at 6 and 12 months. RESULTS: Among 899 enrolled dementia patients, 748 were diagnosed with AD of whom 654 (87%) were taking AChEIs. Baseline WMH showed significant correlations with age, current alcohol consumption, and Clinical Dementia Rating score; baseline HA was correlated with age, family history, physical exercise, and the results of cognitive assessments. Among the AChEI group, changes in the Korean version of the Instrumental Activities of Daily Living (K-IADL) were correlated with the severity of HA on baseline brain MRI, but not with the baseline severity of WMH. In the no AChEI group, changes in K-IADL were correlated with the severity of WMH and HA at baseline. CONCLUSION: Baseline MRI findings could be a useful tool for predicting future clinical outcomes by primary physicians, especially in relation to patients' functional status.
ESTHER : Choi_2018_J.Alzheimers.Dis_66_1721
PubMedSearch : Choi_2018_J.Alzheimers.Dis_66_1721
PubMedID: 30452413

Title : Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes - Seshadri_2005_Science_307_105
Author(s) : Seshadri R , Adrian L , Fouts DE , Eisen JA , Phillippy AM , Methe BA , Ward NL , Nelson WC , DeBoy RT , Khouri HM , Kolonay JF , Dodson RJ , Daugherty SC , Brinkac LM , Sullivan SA , Madupu R , Nelson KE , Kang KH , Impraim M , Tran K , Robinson JM , Forberger HA , Fraser CM , Zinder SH , Heidelberg JF
Ref : Science , 307 :105 , 2005
Abstract : Dehalococcoides ethenogenes is the only bacterium known to reductively dechlorinate the groundwater pollutants, tetrachloroethene (PCE) and trichloroethene, to ethene. Its 1,469,720-base pair chromosome contains large dynamic duplicated regions and integrated elements. Genes encoding 17 putative reductive dehalogenases, nearly all of which were adjacent to genes for transcription regulators, and five hydrogenase complexes were identified. These findings, plus a limited repertoire of other metabolic modes, indicate that D. ethenogenes is highly evolved to utilize halogenated organic compounds and H2. Diversification of reductive dehalogenase functions appears to have been mediated by recent genetic exchange and amplification. Genome analysis provides insights into the organism's complex nutrient requirements and suggests that an ancestor was a nitrogen-fixing autotroph.
ESTHER : Seshadri_2005_Science_307_105
PubMedSearch : Seshadri_2005_Science_307_105
PubMedID: 15637277
Gene_locus related to this paper: dehm1-q3z6q3 , dehm1-q3z6x9 , dehm1-q3z6z2 , dehm1-q3z8f3 , dehm1-q3za50

Title : Genomic insights into methanotrophy: the complete genome sequence of Methylococcus capsulatus (Bath) - Ward_2004_PLoS.Biol_2_e303
Author(s) : Ward N , Larsen O , Sakwa J , Bruseth L , Khouri H , Durkin AS , Dimitrov G , Jiang L , Scanlan D , Kang KH , Lewis M , Nelson KE , Methe B , Wu M , Heidelberg JF , Paulsen IT , Fouts D , Ravel J , Tettelin H , Ren Q , Read T , DeBoy RT , Seshadri R , Salzberg SL , Jensen HB , Birkeland NK , Nelson WC , Dodson RJ , Grindhaug SH , Holt I , Eidhammer I , Jonasen I , Vanaken S , Utterback T , Feldblyum TV , Fraser CM , Lillehaug JR , Eisen JA
Ref : PLoS Biol , 2 :e303 , 2004
Abstract : Methanotrophs are ubiquitous bacteria that can use the greenhouse gas methane as a sole carbon and energy source for growth, thus playing major roles in global carbon cycles, and in particular, substantially reducing emissions of biologically generated methane to the atmosphere. Despite their importance, and in contrast to organisms that play roles in other major parts of the carbon cycle such as photosynthesis, no genome-level studies have been published on the biology of methanotrophs. We report the first complete genome sequence to our knowledge from an obligate methanotroph, Methylococcus capsulatus (Bath), obtained by the shotgun sequencing approach. Analysis revealed a 3.3-Mb genome highly specialized for a methanotrophic lifestyle, including redundant pathways predicted to be involved in methanotrophy and duplicated genes for essential enzymes such as the methane monooxygenases. We used phylogenomic analysis, gene order information, and comparative analysis with the partially sequenced methylotroph Methylobacterium extorquens to detect genes of unknown function likely to be involved in methanotrophy and methylotrophy. Genome analysis suggests the ability of M. capsulatus to scavenge copper (including a previously unreported nonribosomal peptide synthetase) and to use copper in regulation of methanotrophy, but the exact regulatory mechanisms remain unclear. One of the most surprising outcomes of the project is evidence suggesting the existence of previously unsuspected metabolic flexibility in M. capsulatus, including an ability to grow on sugars, oxidize chemolithotrophic hydrogen and sulfur, and live under reduced oxygen tension, all of which have implications for methanotroph ecology. The availability of the complete genome of M. capsulatus (Bath) deepens our understanding of methanotroph biology and its relationship to global carbon cycles. We have gained evidence for greater metabolic flexibility than was previously known, and for genetic components that may have biotechnological potential.
ESTHER : Ward_2004_PLoS.Biol_2_e303
PubMedSearch : Ward_2004_PLoS.Biol_2_e303
PubMedID: 15383840
Gene_locus related to this paper: metca-q60a38 , metca-q60bu6 , metca-q60cn0 , metca-q605j8 , metca-q606x9 , metca-q607f7 , metca-q607m2 , metca-q609v0

Title : Halobacillus salinus sp. nov., isolated from a salt lake on the coast of the East Sea in Korea - Yoon_2003_Int.J.Syst.Evol.Microbiol_53_687
Author(s) : Yoon JH , Kang KH , Park YH
Ref : Int J Syst Evol Microbiol , 53 :687 , 2003
Abstract : A Gram-positive, rod-shaped, endospore-forming, halophilic bacterium (strain HSL-3(T)) was isolated from a salt lake near Hwajinpo beach on the East Sea in Korea and was subjected to a polyphasic taxonomic study. Strain HSL-3(T) grew optimally in the presence of 2-10% (w/v) NaCl. Strain HSL-3(T) showed poor growth in the absence of NaCl and grew in the presence of less than 23% NaCl. The cell wall peptidoglycan type of strain HSL-3(T) was A4beta based on L-Orn-D-Asp. The predominant menaquinone found in strain HSL-3(T) was menaquinone-7 (MK-7). Strain HSL-3(T) had a cellular fatty acid profile containing large amounts of branched fatty acids; the major fatty acids were anteiso-C(15 : 0), iso-C(15 : 0) and iso-C(16 : 0). The DNA G + C content of strain HSL-3(T) was 45 mol%. Phylogenetic analysis based on 16S rDNA sequences showed that strain HSL-3(T) falls within the radiation of the cluster comprising Halobacillus species. Strain HSL-3(T) exhibited levels of 16S rDNA similarity of 97.4-98.4% to the type strains of Halobacillus species. Levels of DNA-DNA relatedness between strain HSL-3(T) and the type strains of all validly named Halobacillus species were in the range 7.3-9.2%. On the basis of phenotypic and phylogenetic data and the genomic distinctiveness, strain HSL-3(T) (= KCCM 41590(T) = JCM 11546(T)) should be placed in the genus Halobacillus as the type strain of a novel species, for which the name Halobacillus salinus sp. nov. is proposed.
ESTHER : Yoon_2003_Int.J.Syst.Evol.Microbiol_53_687
PubMedSearch : Yoon_2003_Int.J.Syst.Evol.Microbiol_53_687
PubMedID: 12807188
Gene_locus related to this paper: 9baci-a0a4z0gym9