| Title : Metabolomics reveals soluble epoxide hydrolase as a therapeutic target for high-sucrose diet-mediated gut barrier dysfunction - Lin_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2409841121 |
| Author(s) : Lin AZ , Fu X , Jiang Q , Zhou X , Hwang SH , Yin HH , Ni KD , Pan QJ , He X , Zhang LT , Meng YW , Liu YN , Hammock BD , Liu JY |
| Ref : Proc Natl Acad Sci U S A , 121 :e2409841121 , 2024 |
| Abstract : |
| PubMedSearch : Lin_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2409841121 |
| PubMedID: 39556751 |
| Title : Enzyme-Activated Multifunctional Prodrug Combining Site-Specific Chemotherapy with Light-Triggered Photodynamic Therapy - Zhang_2022_Mol.Pharm__ |
| Author(s) : Zhang HX , Lin HH , Su D , Yang DC , Liu JY |
| Ref : Mol Pharm , : , 2022 |
| Abstract : |
| PubMedSearch : Zhang_2022_Mol.Pharm__ |
| PubMedID: 35034440 |
| Title : Targeted Metabolomics Study of Human Plasma Revealed Activation of the Cytochrome P450 Epoxygenase\/Epoxide Hydrolase Axis in Patients with IgA Nephropathy - Deng_2022_J.Proteome.Res__ |
| Author(s) : Deng BQ , Li MY , Fu X , Luo Y , Qiao Q , Liu JY |
| Ref : J Proteome Res , : , 2022 |
| Abstract : |
| PubMedSearch : Deng_2022_J.Proteome.Res__ |
| PubMedID: 36301320 |
| Title : N-Benzyl-linoleamide, a Constituent of Lepidium meyenii (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain - Singh_2020_J.Nat.Prod_83_3689 |
| Author(s) : Singh N , Barnych B , Morisseau C , Wagner KM , Wan D , Takeshita A , Pham H , Xu T , Dandekar A , Liu JY , Hammock BD |
| Ref : Journal of Natural Products , 83 :3689 , 2020 |
| Abstract : |
| PubMedSearch : Singh_2020_J.Nat.Prod_83_3689 |
| PubMedID: 33320645 |
| Title : Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK - Luo_2019_Proc.Natl.Acad.Sci.U.S.A_116_5154 |
| Author(s) : Luo Y , Wu MY , Deng BQ , Huang J , Hwang SH , Li MY , Zhou CY , Zhang QY , Yu HB , Zhao DK , Zhang G , Qin L , Peng A , Hammock BD , Liu JY |
| Ref : Proc Natl Acad Sci U S A , 116 :5154 , 2019 |
| Abstract : |
| PubMedSearch : Luo_2019_Proc.Natl.Acad.Sci.U.S.A_116_5154 |
| PubMedID: 30804206 |
| Title : Inhibition of Soluble Epoxide Hydrolase for Renal Health - Liu_2018_Front.Pharmacol_9_1551 |
| Author(s) : Liu JY |
| Ref : Front Pharmacol , 9 :1551 , 2018 |
| Abstract : |
| PubMedSearch : Liu_2018_Front.Pharmacol_9_1551 |
| PubMedID: 30687105 |
| Title : Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use - Liu_2016_J.Ethnopharmacol_194_475 |
| Author(s) : Liu JY , Morisseau C , Huang H , Hammock BD |
| Ref : J Ethnopharmacol , 194 :475 , 2016 |
| Abstract : |
| PubMedSearch : Liu_2016_J.Ethnopharmacol_194_475 |
| PubMedID: 27702689 |
| Title : In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors - Liu_2015_Biochem.Pharmacol_98_718 |
| Author(s) : Liu JY , Tsai HJ , Morisseau C , Lango J , Hwang SH , Watanabe T , Kim IH , Hammock BD |
| Ref : Biochemical Pharmacology , 98 :718 , 2015 |
| Abstract : |
| PubMedSearch : Liu_2015_Biochem.Pharmacol_98_718 |
| PubMedID: 26494425 |
| Title : Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase - Fako_2015_J.Med.Chem_58_778 |
| Author(s) : Fako VE , Wu X , Pflug B , Liu JY , Zhang JT |
| Ref : Journal of Medicinal Chemistry , 58 :778 , 2015 |
| Abstract : |
| PubMedSearch : Fako_2015_J.Med.Chem_58_778 |
| PubMedID: 25513712 |
| Title : Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase - Fako_2014_ACS.Catal_4_3444 |
| Author(s) : Fako VE , Zhang JT , Liu JY |
| Ref : ACS Catal , 4 :3444 , 2014 |
| Abstract : |
| PubMedSearch : Fako_2014_ACS.Catal_4_3444 |
| PubMedID: 25309810 |
| Gene_locus related to this paper: human-FASN |
| Title : Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy - Lee_2014_J.Med.Chem_57_7016 |
| Author(s) : Lee KS , Liu JY , Wagner KM , Pakhomova S , Dong H , Morisseau C , Fu SH , Yang J , Wang P , Ulu A , Mate CA , Nguyen LV , Hwang SH , Edin ML , Mara AA , Wulff H , Newcomer ME , Zeldin DC , Hammock BD |
| Ref : Journal of Medicinal Chemistry , 57 :7016 , 2014 |
| Abstract : |
| PubMedSearch : Lee_2014_J.Med.Chem_57_7016 |
| PubMedID: 25079952 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis - Zhang_2014_Proc.Natl.Acad.Sci.U.S.A_111_11127 |
| Author(s) : Zhang G , Panigrahy D , Hwang SH , Yang J , Mahakian LM , Wettersten HI , Liu JY , Wang Y , Ingham ES , Tam S , Kieran MW , Weiss RH , Ferrara KW , Hammock BD |
| Ref : Proc Natl Acad Sci U S A , 111 :11127 , 2014 |
| Abstract : |
| PubMedSearch : Zhang_2014_Proc.Natl.Acad.Sci.U.S.A_111_11127 |
| PubMedID: 25024195 |
| Title : Key amino acid associated with acephate detoxification by Cydia pomonella carboxylesterase based on molecular dynamics with alanine scanning and site-directed mutagenesis - Yang_2014_J.Chem.Inf.Model_54_1356 |
| Author(s) : Yang XQ , Liu JY , Li XC , Chen MH , Zhang YL |
| Ref : J Chem Inf Model , 54 :1356 , 2014 |
| Abstract : |
| PubMedSearch : Yang_2014_J.Chem.Inf.Model_54_1356 |
| PubMedID: 24749772 |
| Gene_locus related to this paper: cydpo-a0a0c4jzc5 |
| Title : Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models - Liu_2013_Eur.J.Pharm.Sci_48_619 |
| Author(s) : Liu JY , Lin YP , Qiu H , Morisseau C , Rose TE , Hwang SH , Chiamvimonvat N , Hammock BD |
| Ref : Eur J Pharm Sci , 48 :619 , 2013 |
| Abstract : |
| PubMedSearch : Liu_2013_Eur.J.Pharm.Sci_48_619 |
| PubMedID: 23291046 |
| Title : A thermostable and organic-solvent tolerant esterase from Pseudomonas putida ECU1011: catalytic properties and performance in kinetic resolution of alpha-hydroxy acids - Ma_2013_Bioresour.Technol_133_354 |
| Author(s) : Ma BD , Yu HL , Pan J , Liu JY , Ju X , Xu JH |
| Ref : Bioresour Technol , 133 :354 , 2013 |
| Abstract : |
| PubMedSearch : Ma_2013_Bioresour.Technol_133_354 |
| PubMedID: 23434813 |
| Gene_locus related to this paper: 9psed-l7pyq2 |
| Title : Isolation and biochemical characterization of two novel metagenome-derived esterases - Ouyang_2013_Appl.Biochem.Biotechnol_169_15 |
| Author(s) : Ouyang LM , Liu JY , Qiao M , Xu JH |
| Ref : Appl Biochem Biotechnol , 169 :15 , 2013 |
| Abstract : |
| PubMedSearch : Ouyang_2013_Appl.Biochem.Biotechnol_169_15 |
| PubMedID: 23117418 |
| Gene_locus related to this paper: 9zzzz-f8v182 |
| Title : Juvenile hormone (JH) esterase of the mosquito Culex quinquefasciatus is not a target of the JH analog insecticide methoprene - Kamita_2011_PLoS.One_6_e28392 |
| Author(s) : Kamita SG , Samra AI , Liu JY , Cornel AJ , Hammock BD |
| Ref : PLoS ONE , 6 :e28392 , 2011 |
| Abstract : |
| PubMedSearch : Kamita_2011_PLoS.One_6_e28392 |
| PubMedID: 22174797 |
| Gene_locus related to this paper: culqu-b0w3q7 |
| Title : Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase - Hwang_2011_J.Med.Chem_54_3037 |
| Author(s) : Hwang SH , Wagner KM , Morisseau C , Liu JY , Dong H , Wecksler AT , Hammock BD |
| Ref : Journal of Medicinal Chemistry , 54 :3037 , 2011 |
| Abstract : |
| PubMedSearch : Hwang_2011_J.Med.Chem_54_3037 |
| PubMedID: 21434686 |
| Title : 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain - Rose_2010_J.Med.Chem_53_7067 |
| Author(s) : Rose TE , Morisseau C , Liu JY , Inceoglu B , Jones PD , Sanborn JR , Hammock BD |
| Ref : Journal of Medicinal Chemistry , 53 :7067 , 2010 |
| Abstract : |
| PubMedSearch : Rose_2010_J.Med.Chem_53_7067 |
| PubMedID: 20812725 |
| Title : Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model - Liu_2010_Biochem.Pharmacol_79_880 |
| Author(s) : Liu JY , Yang J , Inceoglu B , Qiu H , Ulu A , Hwang SH , Chiamvimonvat N , Hammock BD |
| Ref : Biochemical Pharmacology , 79 :880 , 2010 |
| Abstract : |
| PubMedSearch : Liu_2010_Biochem.Pharmacol_79_880 |
| PubMedID: 19896470 |
| Title : Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties - Huang_2010_J.Med.Chem_53_8376 |
| Author(s) : Huang SX , Li HY , Liu JY , Morisseau C , Hammock BD , Long YQ |
| Ref : Journal of Medicinal Chemistry , 53 :8376 , 2010 |
| Abstract : |
| PubMedSearch : Huang_2010_J.Med.Chem_53_8376 |
| PubMedID: 21070033 |
| Title : Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation - Liu_2009_Br.J.Pharmacol_156_284 |
| Author(s) : Liu JY , Tsai HJ , Hwang SH , Jones PD , Morisseau C , Hammock BD |
| Ref : British Journal of Pharmacology , 156 :284 , 2009 |
| Abstract : |
| PubMedSearch : Liu_2009_Br.J.Pharmacol_156_284 |
| PubMedID: 19154430 |
| Title : Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo - Liu_2009_Mol.Cancer.Ther_8_2193 |
| Author(s) : Liu JY , Park SH , Morisseau C , Hwang SH , Hammock BD , Weiss RH |
| Ref : Mol Cancer Ther , 8 :2193 , 2009 |
| Abstract : |
| PubMedSearch : Liu_2009_Mol.Cancer.Ther_8_2193 |
| PubMedID: 19671760 |
| Title : Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches - Li_2009_J.Mol.Cell.Cardiol_47_835 |
| Author(s) : Li N , Liu JY , Timofeyev V , Qiu H , Hwang SH , Tuteja D , Lu L , Yang J , Mochida H , Low R , Hammock BD , Chiamvimonvat N |
| Ref : Journal of Molecular & Cellular Cardiology , 47 :835 , 2009 |
| Abstract : |
| PubMedSearch : Li_2009_J.Mol.Cell.Cardiol_47_835 |
| PubMedID: 19716829 |
| Title : Stereoselective characteristics and mechanisms of epidermal carboxylesterase metabolism observed in HaCaT keratinocytes - Zhu_2007_Biol.Pharm.Bull_30_532 |
| Author(s) : Zhu QG , Hu JH , Liu JY , Lu SW , Liu YX , Wang J |
| Ref : Biol Pharm Bull , 30 :532 , 2007 |
| Abstract : |
| PubMedSearch : Zhu_2007_Biol.Pharm.Bull_30_532 |
| PubMedID: 17329851 |
| Title : Orally bioavailable potent soluble epoxide hydrolase inhibitors - Hwang_2007_J.Med.Chem_50_3825 |
| Author(s) : Hwang SH , Tsai HJ , Liu JY , Morisseau C , Hammock BD |
| Ref : Journal of Medicinal Chemistry , 50 :3825 , 2007 |
| Abstract : |
| PubMedSearch : Hwang_2007_J.Med.Chem_50_3825 |
| PubMedID: 17616115 |