Family: Duf_726

Block: X

Parent Family: No family


A lipase like protein: yeast-yfd4 Mil1(Yfl034w) specifically binds Apm2, one of the adaptor protein of (AP) complexes responsible for binding clathrin, cargo-sorting motifs, accessory factors, and membrane lipids. The paper by Whitfield et al. is the first description of a function for a member of the Duf_726 family. The same protein had been shown to interact with the ribosomal phosphoprotein P0 Aruna et al.. yeast-yfd4 has a conserved catalytic triad. Male-sterile rice mutant oslddt1 (leaked and delayed degraded tapetum 1). oslddt1 plants show complete pollen abortion resulting from delayed degradation of the tapetum and blocked formation of Ubisch bodies and pollen walls. Wax and cutin contents in mature oslddt1 anthers are drastically reduced indicating that orysj-q10ss2 OsLDDT1 OsLDDT1 is involved in fatty acid synthesis and affects formation of the anther epidermis ( Sun et al. 2023)


Interpro : IPR007941 Protein of unknown function DUF726


Pdoc : No Pdoc

Pfam : PF05277 DUF726

Prints : No Print

EC Number : No EC Number


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

Genes Proteins in Duf_726 family (139)

Fragments of genes in Duf_726 family (13)

No fragment of genes

No substrate

No Inhibitor

References (4)

Title : OsLDDT1, encoding a transmembrane structural DUF726 family protein, is essential for tapetum degradation and pollen formation in rice - Sun_2023_Plant.Sci__111596
Author(s) : Sun Z , Liu K , Chen C , Chen D , Peng Z , Zhou R , Liu L , He D , Duan W , Chen H , Huang C , Ruan Z , Zhang Y , Cao L , Zhan X , Cheng S , Sun L
Ref : Plant Sci , :111596 , 2023
PubMedID: 36657664
Gene_locus related to this paper: orysj-q10ss2

Title : The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting - Whitfield_2016_Mol.Biol.Cell_27_588
Author(s) : Whitfield ST , Burston HE , Bean BD , Raghuram N , Maldonado-Baez L , Davey M , Wendland B , Conibear E
Ref : Mol Biology of the cell , 27 :588 , 2016
PubMedID: 26658609
Gene_locus related to this paper: yeast-yfd4

Title : Identification of a hypothetical membrane protein interactor of ribosomal phosphoprotein P0 - Aruna_2004_J.Biosci_29_33
Author(s) : Aruna K , Chakraborty T , Nambeesan S , Mannan AB , Sehgal A , Bhalchandara SR , Sharma S
Ref : J Biosci , 29 :33 , 2004
PubMedID: 15286401
Gene_locus related to this paper: yeast-yfd4

Title : Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast - Baxter_2004_Mol.Cell.Proteomics_3_209
Author(s) : Baxter SM , Rosenblum JS , Knutson S , Nelson MR , Montimurro JS , Di Gennaro JA , Speir JA , Burbaum JJ , Fetrow JS
Ref : Mol Cell Proteomics , 3 :209 , 2004
PubMedID: 14645503
Gene_locus related to this paper: yeast-FSH1 , yeast-FSH2 , yeast-FSH3 , yeast-mgll , yeast-ppme1 , yeast-YDR428C , yeast-yfd4 , yeast-YLR118c