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Family Report for: FSH1


Family FSH1
Block X
Family of serine hydrolase 1(FSH1). Previously: Domain of unknown function (DUF341). Contains human-OVCA2 Human Candidate tumor suppressor in ovarian cancer and yeast-FSH3 regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae, may be involved in folate metabolism. Contains also the gene (dfr1) encoding FSH1 linked to a domain corresponding to dihydrofolate reductase (DHFR) in Schizosaccharomyces pombe. Fsh1p was identified as a lysophospholipase that specifically acts on lysophosphatidylserine (LPS) and impacts the lipid homeostasis in S. cerevisiae. Contains also Aspergillus terreus esterase LovG, which catalyzes the release of covalently bound dihydromonacolin L from LovB during lovastatin biosynthesis. OVCA2 has a strong preference for long-chain alkyl ester substrates (>10-carbons) and high selectivity against a variety of short, branched, and substituted esters

IPR005645 (Serine hydrolase FSH FSH_dom)
PF03959 (FSH1)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

8 more
    Title: FSH1 encodes lysophospholipase activity in Saccharomyces cerevisiae
    Ramachandran G, Chidambaram R, Nachiappan V
    Ref: Biotechnol Lett, 43:279, 2021 : PubMed


    Title: Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae
    Bun JS, Slack MD, Schemenauer DE, Johnson RJ
    Ref: PLoS ONE, 15:e0230166, 2020 : PubMed


    Title: FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae
    Gowsalya R, Ravi C, Kannan M, Nachiappan V
    Ref: FEMS Yeast Res, 19:, 2019 : PubMed


Other Papers

No structure scheme yet for this family

Structures in FSH1 family (1)

Genes Proteins in FSH1 family (123)

Fragments of genes in FSH1 family (19)

Substrates of some enzymes in the FSH1 family (1)

Inhibitors of some enzymes in the FSH1 family (1)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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