Gene_locus Report for: bacan-BA3068 Bacillus anthracis (strain Ames) hypothetical protein
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Firmicutes: N E > Bacilli: N E > Bacillales: N E > Bacillaceae: N E > Bacillus: N E > Bacillus cereus group: N E > Bacillus anthracis: N E 6_AlphaBeta_hydrolase :
bacan-BA0160 Bacillus anthracis (strain Ames) and Bacillus thuringiensis (subsp. konkukian) hypothetical protein ,
bacan-BA0954 Bacillus anthracis, Bacillus thuringiensis, Lysinibacillus sphaericus, Bacillus cereus; Bacillus mycoides, Bacillus weihenstephanensis, Bifunctional nucleotide sugar epimerase/hydrolase mxaa domain protein ,
bacan-BA1747 Bacillus anthracis (strain Ames) hydrolase, alpha/beta fold family ,
bacan-BA1914 Bacillus anthracis (strain Ames) and Bacillus thuringiensis (subsp. konkukian) Bacillus cereus (strain ZK) hypothetical protein ,
bacan-BA2015 Bacillus anthracis (strain Ames) hypothetical protein ,
bacan-BA2417 Bacillus anthracis (strain Ames) hydrolase, alpha/beta fold family ,
bacan-BA2557 Bacillus anthracis (strain Ames) hypothetical protein ,
bacan-BA2687 ,
bacan-BA2865 Bacillus anthracis (strain Ames) Bacillus cereus MM3 hypothetical protein ,
bacan-BA3187 Bacillus anthracis (strain Ames) hydrolase, alpha/beta fold family ,
bacan-BA3343 Bacillus anthracis (strain Ames) Bacillus thuringiensis (strain Al Hakam) (subsp. konkukian)Bacillus cereus (strain ATCC 10987)hydrolase, alpha/beta fold family ,
bacan-BA3372 Bacillus anthracis (strain Ames) hypothetical protein ,
bacan-BA3877 Bacillus anthracis (strain Ames) and Bacillus thuringiensis (subsp. konkukian) (strain Al Hakam) hydrolase, alpha/beta fold family ,
bacan-BA3887 Bacillus anthracis (strain Ames)Bacillus cereus G9241 hydrolase, alpha/beta fold family .
A85-IroE-IroD-Fes-Yiel :
bacan-BA1242 Bacillus anthracis, Bacillus thuringiensis, hypothetical protein ,
bacan-BA2694 Bacillus anthracis (strain Ames)Bacillus thuringiensis serovar kurstaki str. T03a001 Bacillus cereus ATCC 10876 esterase, putative ,
bacan-BA3863 Bacillus anthracis; Bacillus thuringiensis, Bacillus cereus, hypothetical protein .
Aclacinomycin-methylesterase_RdmC :
bacan-BA2738 Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus, hydrolase, alpha/beta fold family .
AlphaBeta_hydrolase :
bacan-BA1019 Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus, Bacillus thuringiensis hydrolase, alpha/beta fold family ,
bacan-BA3178 Bacillus anthracis; Bacillus thuringiensis; Bacillus cereus; Bacillus weihenstephanensis hypothetical protein ,
bacan-BA4328 Bacillus anthracis (strain Ames) hypothetical protein ,
bacan-BA4577 Bacillus anthracis; Bacillus thuringiensis; Bacillus cereus; hydrolase, alpha/beta fold family .
Bacillus_lip :
bacan-q81tt2 Bacillus anthracis. hypothetical protein .
Bacterial_EstLip_FamX :
bacan-BA1866 Bacillus anthracis Bacillus cereus hypothetical protein .
Bacterial_lip_FamI.5 :
bacan-BA2607 Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus lipase, putative .
BlEst2-lipase-like :
bacan-a0a6l7h3w8 Bacillus anthracis. Uncharacterized protein .
Carbon-carbon_bond_hydrolase :
bacan-BA5136 Bacillus anthracis (strain Ames) Bacillus thuringiensis (subsp. konkukian) (strain Al Hakam) Bacillus cereus G9241 hydrolase, alpha/beta fold family .
Homoserine_transacetylase :
bacan-BA4983 .
LYsophospholipase_carboxylesterase :
bacan-BA3703 Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus, phospholipase/carboxylesterase family protein .
MenH_SHCHC :
bacan-BA5110 Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus, hydrolase, alpha/beta fold family .
Monoglyceridelipase_lysophospholip :
bacan-BA5009 Bacillus anthracis, Bacillus cereus, Bacillus thuringiensis, Bacillus weihenstephanensis lysophospholipase l2 (EC 3.1.1.5) .
PAF-Acetylhydrolase :
bacan-BA0950 Bacillus anthracis (strain Ames) and Bacillus thuringiensis (subsp. konkukian)hypothetical protein .
PC-sterol_acyltransferase :
bacan-BA3805 Bacillus anthracis prophage lambdaba01, acyltransferase, putative .
Proline_iminopeptidase :
bacan-BA2392 Bacillus anthracis; Bacillus thuringiensis, Bacillus cereus, Bacillus weihenstephanensis, Bacillus mycoides, Proline_iminopeptidase ,
bacan-BA4324 Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus, hydrolase .
Thioesterase :
bacan-DHBF Bacillus anthracis, Bacillus thuringiensis, Bacillus mycoides, Bacillus weihenstephanensis, nonribosomal peptide synthetase dhbf Thioesterase domain .
UCP033634 :
bacan-Q81NX8 Bacillus anthracis Uncharacterized protein ,
bacan-a0a1j9w4y5 Bacillus anthracis; Bacillus sp.; Bacillus cereus Uncharacterized protein ,
bacan-a0a1j9wz46 Bacillus anthracis Uncharacterized protein ,
bacan-a0a1t3uyy1 Bacillus anthracis Alpha/beta hydrolase ,
bacan-a0a2a8lbn0 Bacillus anthracis Alpha/beta hydrolase ,
bacan-a0a2a8wij7 Bacillus anthracis; Bacillus cereus Alpha/beta hydrolase ,
bacan-a0a2b0y5d8 Bacillus anthracis Uncharacterized protein ,
bacan-a0a2b8ijf1 Bacillus anthracis Alpha/beta hydrolase Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: bacan-BA3068 Colored MSA for 6_AlphaBeta_hydrolase (raw)
MSNEKILRLVKIIFLMCISIIFFGTGAVFIYHNCQLKMESKLMNNKGELV
NFDNKKVNVYNEGSGEDTFVFMAGSGIAAPVYELKGLYSKFSKENKISVI
ERAGYGYSDVFQDDRDIDTILEQTREALIRSGNKPPYILVPHSLSGIEAI
YWAQKYPSEVKGIIALDIGLPKQYVTNKIGMVNSLKIKGMNILTKIGFQR
LAPSITYNPEVILQSFLNEQEKDVYKALTYKRAFNDDMKQELLQSYNNGK
KSNSLSIPKETPMLFIDAIARQYKDSKYTRQKNKDYKEFASKLLIADVKI
IEGTHSIYLYAPDEIYKIAMDFIKNKVVKN
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M S N E K I L R L V K I I F L M C I S I I F F G T G A V F I Y H N C Q L K M E S K L M N N K G E L V N F D N K K V N V Y N E G S G E D T F V F M A G S G I A A P V Y E L K G L Y S K F S K E N K I S V I E R A G Y G Y S D V F Q D D R D I D T I L E Q T R E A L I R S G N K P P Y I L V P H S L S G I E A I Y W A Q K Y P S E V K G I I A L D I G L P K Q Y V T N K I G M V N S L K I K G M N I L T K I G F Q R L A P S I T Y N P E V I L Q S F L N E Q E K D V Y K A L T Y K R A F N D D M K Q E L L Q S Y N N G K K S N S L S I P K E T P M L F I D A I A R Q Y K D S K Y T R Q K N K D Y K E F A S K L L I A D V K I I E G T H S I Y L Y A P D E I Y K I A M D F I K N K V V K N
Reference
Title: The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteriaRead TD , Peterson SN , Tourasse N , Baillie LW , Paulsen IT , Nelson KE , Tettelin H , Fouts DE , Eisen JA and Fraser CM <42 more author(s)> Read TD , Peterson SN , Tourasse N , Baillie LW , Paulsen IT , Nelson KE , Tettelin H , Fouts DE , Eisen JA , Gill SR , Holtzapple EK , Okstad OA , Helgason E , Rilstone J , Wu M , Kolonay JF , Beanan MJ , Dodson RJ , Brinkac LM , Gwinn M , DeBoy RT , Madpu R , Daugherty SC , Durkin AS , Haft DH , Nelson WC , Peterson JD , Pop M , Khouri HM , Radune D , Benton JL , Mahamoud Y , Jiang L , Hance IR , Weidman JF , Berry KJ , Plaut RD , Wolf AM , Watkins KL , Nierman WC , Hazen A , Cline R , Redmond C , Thwaite JE , White O , Salzberg SL , Thomason B , Friedlander AM , Koehler TM , Hanna PC , Kolsto AB , Fraser CM (- 42) Ref: Nature, 423 :81, 2003 : PubMed Abstract ESTHER: Read_2003_Nature_423_81 PubMedSearch: Read 2003 Nature 423 81 PubMedID: 12721629 Gene_locus related to this paper: bacan-BA0160 ,
bacan-BA0950 ,
bacan-BA0954 ,
bacan-BA1019 ,
bacan-BA1242 ,
bacan-BA1727 ,
bacan-BA1747 ,
bacan-BA1866 ,
bacan-BA1914 ,
bacan-BA2015 ,
bacan-BA2392 ,
bacan-BA2417 ,
bacan-BA2557 ,
bacan-BA2607 ,
bacan-BA2687 ,
bacan-BA2694 ,
bacan-BA2738 ,
bacan-BA2865 ,
bacan-BA3068 ,
bacan-BA3165 ,
bacan-BA3178 ,
bacan-BA3187 ,
bacan-BA3343 ,
bacan-BA3372 ,
bacan-BA3703 ,
bacan-BA3805 ,
bacan-BA3863 ,
bacan-BA3877 ,
bacan-BA3887 ,
bacan-BA4324 ,
bacan-BA4328 ,
bacan-BA4338 ,
bacan-BA4577 ,
bacan-BA4983 ,
bacan-BA5009 ,
bacan-BA5110 ,
bacan-BA5136 ,
bacan-DHBF ,
bacan-q81tt2 ,
bacce-BC0192 ,
bacce-BC1788 ,
bacce-BC1954 ,
bacce-BC2141 ,
bacce-BC2171 ,
bacce-BC4730 ,
bacce-BC4862 ,
bacce-BC5130 ,
bacce-PHAC ,
bacce-q72yu1 ,
baccr-pepx Abstract
Bacillus anthracis is an endospore-forming bacterium that causes inhalational anthrax. Key virulence genes are found on plasmids (extra-chromosomal, circular, double-stranded DNA molecules) pXO1 (ref. 2) and pXO2 (ref. 3). To identify additional genes that might contribute to virulence, we analysed the complete sequence of the chromosome of B. anthracis Ames (about 5.23 megabases). We found several chromosomally encoded proteins that may contribute to pathogenicity--including haemolysins, phospholipases and iron acquisition functions--and identified numerous surface proteins that might be important targets for vaccines and drugs. Almost all these putative chromosomal virulence and surface proteins have homologues in Bacillus cereus, highlighting the similarity of B. anthracis to near-neighbours that are not associated with anthrax. By performing a comparative genome hybridization of 19 B. cereus and Bacillus thuringiensis strains against a B. anthracis DNA microarray, we confirmed the general similarity of chromosomal genes among this group of close relatives. However, we found that the gene sequences of pXO1 and pXO2 were more variable between strains, suggesting plasmid mobility in the group. The complete sequence of B. anthracis is a step towards a better understanding of anthrax pathogenesis.
Other Papers
Bacillus anthracis (strain Ames) hydrolase, and Bacillus cereus (strain ATCC 10987) alpha/beta fold family