pig-ppce
Pig prolyl endopeptidase
Comment
Relationship
Molecular evidence
No mutation
No kinetic
No disease
spiro-b-lactam-pyrroloquinoline-6b
N-acyl-prolylpyrrolidine-inhibitor-1
N-acyl-prolylpyrrolidine-inhibitor-2
N-acyl-prolylpyrrolidine-inhibitor-3
Z-Pro-Prolinal-IC1
Z-Pro-Prolinal-IC2
Z-Pro-Prolinal-IC3
Z-Pro-Prolinal-IC4
Z-Pro-Prolinal-derived
R-Pro-(decarboxy-Pro)-X99
R-Pro-(decarboxy-Pro)-X98
R-Pro-(decarboxy-Pro)-X97
Sin-Gly-Pro
Z-Pro-Prolinal
Z-Gly-Pro
Sequence
Peptide
MLSFQYPDVY RDETAIQDYH GHKVCDPYAW LEDPDSEQTK AFVEAQNKIT VPFLEQCPIR GLYKERMTEL YDYPKYSCHF KKGKRYFYFY NTGLQNQRVL YVQDSLEGEA RVFLDPNILS DDGTVALRGY AFSEDGEYFA YGLSASGSDW VTIKFMKVDG AKELPDVLER VKFSCMAWTH DGKGMFYNAY PQQDGKSDGT ETSTNLHQKL YYHVLGTDQS EDILCAEFPD EPKWMGGAEL SDDGRYVLLS IREGCDPVNR LWYCDLQQES NGITGILKWV KLIDNFEGEY DYVTNEGTVF TFKTNRHSPN YRLINIDFTD PEESKWKVLV PEHEKDVLEW VACVRSNFLV LCYLHDVKNT LQLHDLATGA LLKIFPLEVG SVVGYSGQKK DTEIFYQFTS FLSPGIIYHC DLTKEELEPR VFREVTVKGI DASDYQTVQI FYPSKDGTKI PMFIVHKKGI KLDGSHPAFL YGYGGFNISI TPNYSVSRLI FVRHMGGVLA VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE GYTSPKRLTI NGGSNGGLLV ATCANQRPDL FGCVIAQVGV MDMLKFHKYT IGHAWTTDYG CSDSKQHFEW LIKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSL KFIATLQYIV GRSRKQNNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI ARCLNIDWIP
References
| Title : Substrate-like novel inhibitors of prolyl specific oligo peptidase for neurodegenerative disorders - Khan_2023_J.Biomol.Struct.Dyn__1 |
| Author(s) : Khan M , Halim SA , Waqas M , Golmohammadi F , Balalaie S , Csuk R , Uddin J , Khan A , Al-Harrasi A |
| Ref : J Biomol Struct Dyn , :1 , 2023 |
| Abstract : Khan_2023_J.Biomol.Struct.Dyn__1 |
| ESTHER : Khan_2023_J.Biomol.Struct.Dyn__1 |
| PubMedSearch : Khan_2023_J.Biomol.Struct.Dyn__1 |
| PubMedID: 37608559 |
| Gene_locus related to this paper: pig-ppce |
| Title : P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy - Van der Veken_2012_J.Med.Chem_55_9856 |
| Author(s) : Van der Veken P , Fulop V , Rea D , Gerard M , Van Elzen R , Joossens J , Cheng JD , Baekelandt V , De Meester I , Lambeir AM , Augustyns K |
| Ref : Journal of Medicinal Chemistry , 55 :9856 , 2012 |
| Abstract : Van der Veken_2012_J.Med.Chem_55_9856 |
| ESTHER : Van der Veken_2012_J.Med.Chem_55_9856 |
| PubMedSearch : Van der Veken_2012_J.Med.Chem_55_9856 |
| PubMedID: 23121075 |
| Gene_locus related to this paper: pig-ppce |
| Title : Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase. - Kaszuba_2012_Biochimie_94_1398 |
| Author(s) : Kaszuba K , Rog T , Danne R , Canning P , Fulop V , Juhasz T , Szeltner Z , St Pierre JF , Garcia-Horsman A , Mannisto PT , Karttunen M , Hokkanen J , Bunker A |
| Ref : Biochimie , 94 :1398 , 2012 |
| Abstract : Kaszuba_2012_Biochimie_94_1398 |
| ESTHER : Kaszuba_2012_Biochimie_94_1398 |
| PubMedSearch : Kaszuba_2012_Biochimie_94_1398 |
| PubMedID: 22484394 |
| Gene_locus related to this paper: pig-ppce |
| Title : The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity - Szeltner_2012_Biochim.Biophys.Acta_1834_98 |
| Author(s) : Szeltner Z , Juhasz T , Szamosi I , Rea D , Fulop V , Modos K , Juliano L , Polgar L |
| Ref : Biochimica & Biophysica Acta , 1834 :98 , 2012 |
| Abstract : Szeltner_2012_Biochim.Biophys.Acta_1834_98 |
| ESTHER : Szeltner_2012_Biochim.Biophys.Acta_1834_98 |
| PubMedSearch : Szeltner_2012_Biochim.Biophys.Acta_1834_98 |
| PubMedID: 22940581 |
| Gene_locus related to this paper: pig-ppce |
| Title : Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide - Racys_2010_Bioorg.Med.Chem_18_4775 |
| Author(s) : Racys DT , Rea D , Fulop V , Wills M |
| Ref : Bioorganic & Medicinal Chemistry , 18 :4775 , 2010 |
| Abstract : Racys_2010_Bioorg.Med.Chem_18_4775 |
| ESTHER : Racys_2010_Bioorg.Med.Chem_18_4775 |
| PubMedSearch : Racys_2010_Bioorg.Med.Chem_18_4775 |
| PubMedID: 20627594 |
| Gene_locus related to this paper: pig-ppce |
| Title : Electrostatic environment at the active site of prolyl oligopeptidase is highly influential during substrate binding - Szeltner_2003_J.Biol.Chem_278_48786 |
| Author(s) : Szeltner Z , Rea D , Renner V , Juliano L , Fulop V , Polgar L |
| Ref : Journal of Biological Chemistry , 278 :48786 , 2003 |
| Abstract : Szeltner_2003_J.Biol.Chem_278_48786 |
| ESTHER : Szeltner_2003_J.Biol.Chem_278_48786 |
| PubMedSearch : Szeltner_2003_J.Biol.Chem_278_48786 |
| PubMedID: 14514675 |
| Gene_locus related to this paper: pig-ppce |
| Title : Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site - Szeltner_2002_J.Biol.Chem_277_42613 |
| Author(s) : Szeltner Z , Rea D , Renner V , Fulop V , Polgar L |
| Ref : Journal of Biological Chemistry , 277 :42613 , 2002 |
| Abstract : Szeltner_2002_J.Biol.Chem_277_42613 |
| ESTHER : Szeltner_2002_J.Biol.Chem_277_42613 |
| PubMedSearch : Szeltner_2002_J.Biol.Chem_277_42613 |
| PubMedID: 12202494 |
| Gene_locus related to this paper: pig-ppce |
| Title : Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase - Szeltner_2002_J.Biol.Chem_277_44597 |
| Author(s) : Szeltner Z , Rea D , Juhasz T , Renner V , Mucsi Z , Orosz G , Fulop V , Polgar L |
| Ref : Journal of Biological Chemistry , 277 :44597 , 2002 |
| Abstract : Szeltner_2002_J.Biol.Chem_277_44597 |
| ESTHER : Szeltner_2002_J.Biol.Chem_277_44597 |
| PubMedSearch : Szeltner_2002_J.Biol.Chem_277_44597 |
| PubMedID: 12228249 |
| Gene_locus related to this paper: pig-ppce |
| Title : Structures of prolyl oligopeptidase substrate\/inhibitor complexes. Use of inhibitor binding for titration of the catalytic histidine residue - Fulop_2001_J.Biol.Chem_276_1262 |
| Author(s) : Fulop V , Szeltner Z , Renner V , Polgar L |
| Ref : Journal of Biological Chemistry , 276 :1262 , 2001 |
| Abstract : Fulop_2001_J.Biol.Chem_276_1262 |
| ESTHER : Fulop_2001_J.Biol.Chem_276_1262 |
| PubMedSearch : Fulop_2001_J.Biol.Chem_276_1262 |
| PubMedID: 11031266 |
| Gene_locus related to this paper: pig-ppce |
| Title : Catalysis of serine oligopeptidases is controlled by a gating filter mechanism - Fulop_2000_EMBO.Rep_1_277 |
| Author(s) : Fulop V , Szeltner Z , Polgar L |
| Ref : EMBO Rep , 1 :277 , 2000 |
| Abstract : Fulop_2000_EMBO.Rep_1_277 |
| ESTHER : Fulop_2000_EMBO.Rep_1_277 |
| PubMedSearch : Fulop_2000_EMBO.Rep_1_277 |
| PubMedID: 11256612 |
| Gene_locus related to this paper: pig-ppce |
| Title : Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis - Fulop_1998_Cell_94_161 |
| Author(s) : Fulop V , Bocskei Z , Polgar L |
| Ref : Cell , 94 :161 , 1998 |
| Abstract : Fulop_1998_Cell_94_161 |
| ESTHER : Fulop_1998_Cell_94_161 |
| PubMedSearch : Fulop_1998_Cell_94_161 |
| PubMedID: 9695945 |
| Gene_locus related to this paper: pig-ppce |
| Title : cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue - Rennex_1991_Biochemistry_30_2195 |
| Author(s) : Rennex D , Hemmings BA , Hofsteenge J , Stone SR |
| Ref : Biochemistry , 30 :2195 , 1991 |
| Abstract : Rennex_1991_Biochemistry_30_2195 |
| ESTHER : Rennex_1991_Biochemistry_30_2195 |
| PubMedSearch : Rennex_1991_Biochemistry_30_2195 |
| PubMedID: 1900195 |
| Gene_locus related to this paper: pig-ppce |
| Title : Inactivation of prolyl endopeptidase by a peptidylchloromethane. Kinetics of inactivation and identification of sites of modification - Stone_1991_Biochem.J_276 ( Pt 3)_837 |
| Author(s) : Stone SR , Rennex D , Wikstrom P , Shaw E , Hofsteenge J |
| Ref : Biochemical Journal , 276 ( Pt 3) :837 , 1991 |
| Abstract : Stone_1991_Biochem.J_276 ( Pt 3)_837 |
| ESTHER : Stone_1991_Biochem.J_276 ( Pt 3)_837 |
| PubMedSearch : Stone_1991_Biochem.J_276 ( Pt 3)_837 |
| PubMedID: 2064618 |
| Gene_locus related to this paper: pig-ppce |