7-methoxytacrine-memantine-Cpd4
IC50 AChE 0.47+/- 0.09 microM, IC50 BChE 0.11+/-0.02 microM GluN1/GluN2B receptor Ki 1.8 microM
General
Type : Multitarget, NMDA-Ligand, Adamantyl, Urea derivative, Alkyl linked bis-ligand, Sulfur Compound, Derivative of Tacrine
Chemical_Nomenclature : 1-(1-adamantyl)-3-[5-[(7-methoxy-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl]thiourea
Canonical SMILES : COC1=CC2=C(C=C1)N=C3CCCCC3=C2NCCCCCNC(=S)NC45CC6CC(C4)CC(C6)C5
InChI : InChI=1S\/C30H42N4OS\/c1-35-23-9-10-27-25(16-23)28(24-7-3-4-8-26(24)33-27)31-11-5-2-6-12-32-29(36)34-30-17-20-13-21(18-30)15-22(14-20)19-30\/h9-10,16,20-22H,2-8,11-15,17-19H2,1H3,(H,31,33)(H2,32,34,36)
InChIKey : DANIUTWEXULISV-UHFFFAOYSA-N
Other name(s) : CHEMBL4469066, BDBM50502562
MW : 506.7
Formula : C30H42N4OS
CAS_number :
PubChem : 155533705
UniChem : DANIUTWEXULISV-UHFFFAOYSA-N
Target
Families : 7-methoxytacrine-memantine-Cpd4 ligand of proteins in family
ACHE
References (1)
| Title : Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment - Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| Author(s) : Gazova Z , Soukup O , Sepsova V , Siposova K , Drtinova L , Jost P , Spilovska K , Korabecny J , Nepovimova E , Fedunova D , Horak M , Kaniakova M , Wang ZJ , Hamouda AK , Kuca K |
| Ref : Biochimica & Biophysica Acta Mol Basis Dis , 1863 :607 , 2017 |
| PubMedID: 27865910 |