ADS031
hH3R Ki 12.5 nM, AChE IC50 1537 nM
General
Type : Histamine-Receptor3-H3-Antagonist, Multitarget, Piperidine, Naphthalen
Chemical_Nomenclature : N-((6-(((1-Benzylpiperidin-4-yl)oxy)methyl)naphthalen-2-yl)-methyl)-N-methylpropan-1-amine
Canonical SMILES : C1=CC(=CC=C1)CN2CCC(CC2)OCC3=CC=C4C(=C3)C=CC(=C4)CN(C)CCC
InChI : InChI=1S\/C28H36N2O\/c1-3-15-29(2)20-24-9-11-27-19-25(10-12-26(27)18-24)22-31-28-13-16-30(17-14-28)21-23-7-5-4-6-8-23\/h4-12,18-19,28H,3,13-17,20-22H2,1-2H3
InChIKey : QDKNEOIFRGXHQX-UHFFFAOYSA-N
Other name(s) :
Target
Families : ADS031 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : 4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H(3) Receptors and Cholinesterases - Michalska_2024_ACS.Chem.Neurosci__ |
| Author(s) : Michalska B , Dziegielewski M , Godyn J , Werner T , Bajda M , Karcz T , Szczepanska K , Stark H , Wieckowska A , Walczynski K , Staszewski M |
| Ref : ACS Chem Neurosci , : , 2024 |
| Abstract : |
| PubMedSearch : Michalska_2024_ACS.Chem.Neurosci__ |
| PubMedID: 38440987 |