CHEMBL3393736
Tacrine-caffeic acid hybride. electric eel AChE IC50 0.15 microM; horse serum BuChE IC50 0.36 microM
General
Type : Acridine, Derivative of Tacrine, Alkyl linked bis-ligand, anti-Abeta-aggregation, Multitarget, Hydroxycinnamic-ester, Antioxidant
Chemical_Nomenclature : (E)-N-[3-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-2-hydroxypropyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide
Canonical SMILES : C1CCC2=NC3=C(C=CC(=C3)Cl)C(=C2C1)NCC(CNC(=O)\/C=C\/C4=CC(=C(C=C4)O)O)O
InChI : InChI=1S\/C25H26ClN3O4\/c26-16-7-8-19-21(12-16)29-20-4-2-1-3-18(20)25(19)28-14-17(30)13-27-24(33)10-6-15-5-9-22(31)23(32)11-15\/h5-12,17,30-32H,1-4,13-14H2,(H,27,33)(H,28,29)\/b10-6+
InChIKey : FCDQKYLJUPTKRI-UXBLZVDNSA-N
Other name(s) : BDBM50061274 || Compound 1b
MW : 467.9
Formula : C25H26ClN3O4
CAS_number :
PubChem : 118725625
UniChem : FCDQKYLJUPTKRI-UXBLZVDNSA-N
Target
References (1)
| Title : Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD - Digiacomo_2015_Bioorg.Med.Chem.Lett_25_807 |
| Author(s) : Digiacomo M , Chen Z , Wang S , Lapucci A , Macchia M , Yang X , Chu J , Han Y , Pi R , Rapposelli S |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :807 , 2015 |
| Abstract : |
| PubMedSearch : Digiacomo_2015_Bioorg.Med.Chem.Lett_25_807 |
| PubMedID: 25597007 |