CHEMBL4533477
human AChE IC50 10.2 +/- 1.2 nM
General
Type : Derivative of Tacrine, Multitarget, Feruloyl, Acrylate, Antioxidant, Hydroxycinnamic-ester, Alkyl linked bis-ligand, pNP
Chemical_Nomenclature : (E)-3-(4-nitrophenyl)-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]prop-2-enamide
Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)NCCCCCCNC(=O)\/C=C\/C4=CC=C(C=C4)[N+](=O)[O-]
InChI : InChI=1S\/C28H32N4O3\/c33-27(18-15-21-13-16-22(17-14-21)32(34)35)29-19-7-1-2-8-20-30-28-23-9-3-5-11-25(23)31-26-12-6-4-10-24(26)28\/h3,5,9,11,13-18H,1-2,4,6-8,10,12,19-20H2,(H,29,33)(H,30,31)\/b18-15+
InChIKey : KLTSFNXPVWLHSI-OBGWFSINSA-N
Other name(s) : Compound 19
MW : 472.6
Formula : C28H32N4O3
CAS_number :
PubChem : 155547425
UniChem : KLTSFNXPVWLHSI-OBGWFSINSA-N
Target
Families : CHEMBL4533477 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (2)
| Title : Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer's disease - Chen_2018_J.Enzyme.Inhib.Med.Chem_33_290 |
| Author(s) : Chen Y , Zhu J , Mo J , Yang H , Jiang X , Lin H , Gu K , Pei Y , Wu L , Tan R , Hou J , Chen J , Lv Y , Bian Y , Sun H |
| Ref : J Enzyme Inhib Med Chem , 33 :290 , 2018 |
| Abstract : |
| PubMedSearch : Chen_2018_J.Enzyme.Inhib.Med.Chem_33_290 |
| PubMedID: 29278947 |
| Title : Medicinal chemistry of acridine and its analogues - Prasher_2018_Medchemcomm_9_1589 |
| Author(s) : Prasher P , Sharma M |
| Ref : Medchemcomm , 9 :1589 , 2018 |
| Abstract : |
| PubMedSearch : Prasher_2018_Medchemcomm_9_1589 |
| PubMedID: 30429967 |