DP-802-pyrazol-benzyl(methyl)carbamate-13a
Derivative of DP-802. IC50 microM +/- SEM: p38aMAPK 8.12 +/- 3.085: hBChE 0.0051 +/- 0.00024; hAChE 3.10 +/- 0.32
General
Type : Multitarget, Carbamate, Pyrazole, tert-Butyl, p38-MAPK-inhibitor
Chemical_Nomenclature : 1-(3-((2-acetamidoacetamido)methyl)phenyl)-3-(tert-butyl)-1H-pyrazol-5-yl benzyl(methyl)carbamate
Canonical SMILES : C1(=CC(=CC=C1)[N]2C(=CC(=N2)C(C)(C)C)OC(N(CC3=CC=CC=C3)C)=O)CNC(CNC(C)=O)=O
InChI : InChI=1S\/C27H33N5O4\/c1-19(33)28-17-24(34)29-16-21-12-9-13-22(14-21)32-25(15-23(30-32)27(2,3)4)36-26(35)31(5)18-20-10-7-6-8-11-20\/h6-15H,16-18H2,1-5H3,(H,28,33)(H,29,34)
InChIKey : CUIIAOYBGPSUSK-UHFFFAOYSA-N
Other name(s) :
carbamate-13a.gif)
Target
Families : DP-802-pyrazol-benzyl(methyl)carbamate-13a ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Transforming ureas into carbamates: From allosteric p38alpha MAPK ligands to dual BChE\/p38alpha MAPK inhibitors - Ferjancic Benetik_2025_Bioorg.Chem_165_108998 |
| Author(s) : Benetik SF , Meden A , Knez D , Mastnak-Sokolov P , Kosak U , Horvat S , Pislar A , Andrys R , Musilek K , Detka J , Salat K , Obreza A , Gobec S |
| Ref : Bioorg Chem , 165 :108998 , 2025 |
| Abstract : |
| PubMedSearch : Ferjancic Benetik_2025_Bioorg.Chem_165_108998 |
| PubMedID: 40987175 |
| Gene_locus related to this paper: human-BCHE |