JW972
General
Type : pNP, Carbamate, Piperidine, Alkyne
Chemical_Nomenclature :
Canonical SMILES : C1CCC(N(C1)C(OC2=CC=C([N+](=O)[O-])C=C2)=O)CCCOCC#C
InChI : InChI=1S\/C18H22N2O5\/c1-2-13-24-14-5-7-15-6-3-4-12-19(15)18(21)25-17-10-8-16(9-11-17)20(22)23\/h1,8-11,15H,3-7,12-14H2
InChIKey : GPJCWNHUWPSXOF-UHFFFAOYSA-N
Other name(s) :
Target
Families : JW972 ligand of proteins in family
Carb_B_Chordata
Protein :
human-CES3
mouse-Ces1f
References (6)
| Title : Carboxylesterase 1d-mediated aglycone recognition is crucial for substrate processing and allosteric activation of endo-alpha-mannosidase in the endoplasmic reticulum - Taira_2026_Bioorg.Med.Chem_134_118547 |
| Author(s) : Taira A , Kuribara T , Hirose M , Totani K |
| Ref : Bioorganic & Medicinal Chemistry , 134 :118547 , 2026 |
| Abstract : |
| PubMedSearch : Taira_2026_Bioorg.Med.Chem_134_118547 |
| PubMedID: 41505878 |
| Gene_locus related to this paper: mouse-Ces1d |
| Title : Carboxylesterase 1d-mediated aglycone recognition is crucial for substrate processing and allosteric activation of endo-alpha-mannosidase in the endoplasmic reticulum - Taira_2026_Bioorg.Med.Chem_134_118547 |
| Author(s) : Taira A , Kuribara T , Hirose M , Totani K |
| Ref : Bioorganic & Medicinal Chemistry , 134 :118547 , 2026 |
| Abstract : |
| PubMedSearch : Taira_2026_Bioorg.Med.Chem_134_118547 |
| PubMedID: 41505878 |
| Gene_locus related to this paper: mouse-Ces1d |
| Title : Carboxylesterase 1d-mediated aglycone recognition is crucial for substrate processing and allosteric activation of endo-alpha-mannosidase in the endoplasmic reticulum - Taira_2026_Bioorg.Med.Chem_134_118547 |
| Author(s) : Taira A , Kuribara T , Hirose M , Totani K |
| Ref : Bioorganic & Medicinal Chemistry , 134 :118547 , 2026 |
| Abstract : |
| PubMedSearch : Taira_2026_Bioorg.Med.Chem_134_118547 |
| PubMedID: 41505878 |
| Gene_locus related to this paper: mouse-Ces1d |
| Title : Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes - Dominguez_2014_Nat.Chem.Biol_10_113 |
| Author(s) : Dominguez E , Galmozzi A , Chang JW , Hsu KL , Pawlak J , Li W , Godio C , Thomas J , Partida D , Niessen S , O'Brien PE , Russell AP , Watt MJ , Nomura DK , Cravatt BF , Saez E |
| Ref : Nat Chemical Biology , 10 :113 , 2014 |
| Abstract : |
| PubMedSearch : Dominguez_2014_Nat.Chem.Biol_10_113 |
| PubMedID: 24362705 |
| Gene_locus related to this paper: human-CES3 , mouse-Ces1d |
| Title : Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes - Dominguez_2014_Nat.Chem.Biol_10_113 |
| Author(s) : Dominguez E , Galmozzi A , Chang JW , Hsu KL , Pawlak J , Li W , Godio C , Thomas J , Partida D , Niessen S , O'Brien PE , Russell AP , Watt MJ , Nomura DK , Cravatt BF , Saez E |
| Ref : Nat Chemical Biology , 10 :113 , 2014 |
| Abstract : |
| PubMedSearch : Dominguez_2014_Nat.Chem.Biol_10_113 |
| PubMedID: 24362705 |
| Gene_locus related to this paper: human-CES3 , mouse-Ces1d |
| Title : Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes - Dominguez_2014_Nat.Chem.Biol_10_113 |
| Author(s) : Dominguez E , Galmozzi A , Chang JW , Hsu KL , Pawlak J , Li W , Godio C , Thomas J , Partida D , Niessen S , O'Brien PE , Russell AP , Watt MJ , Nomura DK , Cravatt BF , Saez E |
| Ref : Nat Chemical Biology , 10 :113 , 2014 |
| Abstract : |
| PubMedSearch : Dominguez_2014_Nat.Chem.Biol_10_113 |
| PubMedID: 24362705 |
| Gene_locus related to this paper: human-CES3 , mouse-Ces1d |