LEI-463
Cy5 derived Irreversible fluorescent probe IC50 11nM Other name DH-463 LE-463. different derivatives were produced equipped with fluorophores with different excitation/emission wavelengths: LEI-463-BDP-FL, 493/503 nm; LEI-463-BDP-TMR, 542/574 nm, LEI-463-Cy5, 646/662 nm
General
Type : Trifluoro, Indole, Piperazine, Triazol, Fluorescent Probe
Chemical_Nomenclature : 1-(6-(((1-(2-(4-((4-Chlorophenyl)(4-(((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)carbonyl)piperazin-1-yl)methyl)phenoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-6-oxohexyl)-3,3-dimethyl-2-((1E,3E)-5-((E)-1,3,3-trimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-3Hindol-1-ium chloride
Canonical SMILES : C1(=C[N](N=N1)CCOC2=CC=C(C=C2)C(N3CCN(CC3)C(OC(C(F)(F)F)C(F)(F)F)=O)C4=CC=C(C=C4)Cl)CNC(CCCCC[N+]5=C(C(C6=C5C=CC=C6)(C)C)C=CC=CC=C7C(C8=C(N7C)C=CC=C8)(C)C)=O
InChI : InChI=1S\/C58H63ClF6N8O4\/c1-55(2)45-16-11-13-18-47(45)69(5)49(55)20-8-6-9-21-50-56(3,4)46-17-12-14-19-48(46)73(50)31-15-7-10-22-51(74)66-38-43-39-72(68-67-43)36-37-76-44-29-25-41(26-30-44)52(40-23-27-42(59)28-24-40)70-32-34-71(35-33-70)54(75)77-53(57(60,61)62)58(63,64)65\/h6,8-9,11-14,16-21,23-30,39,52-53H,7,10,15,22,31-38H2,1-5H3\/p+1
InChIKey : XJRNGTMPBPQOSB-UHFFFAOYSA-O
Other name(s) : DH-463 || LE-463
Target
Families : LEI-463 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (11)
| Title : Covalent fluorescent probes for 2-arachidonoylglycerol metabolic pathways - Puijmbroeck_2026_Br.J.Pharmacol__ |
| Author(s) : Puijmbroeck NDF , van der Stelt M |
| Ref : British Journal of Pharmacology , : , 2026 |
| Abstract : |
| PubMedSearch : Puijmbroeck_2026_Br.J.Pharmacol__ |
| PubMedID: 41549057 |
| Title : Covalent fluorescent probes for 2-arachidonoylglycerol metabolic pathways - Puijmbroeck_2026_Br.J.Pharmacol__ |
| Author(s) : Puijmbroeck NDF , van der Stelt M |
| Ref : British Journal of Pharmacology , : , 2026 |
| Abstract : |
| PubMedSearch : Puijmbroeck_2026_Br.J.Pharmacol__ |
| PubMedID: 41549057 |
| Title : Spatially resolved mapping of monoacylglycerol lipase activity in the brain - van der Vliet_2025_bioRxiv__ |
| Author(s) : van der Vliet D , Klinkenberg AXY , Platte R , Higgins K , Prokop S , Huizenga MCW , Kraaijevanger L , van Egmond N , Straub VM , Kole MHP , Pacher P , Katona I , Huitinga I , van der Stelt M |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : van der Vliet_2025_bioRxiv__ |
| PubMedID: 40672305 |
| Title : Spatially resolved mapping of monoacylglycerol lipase activity in the brain - van der Vliet_2025_bioRxiv__ |
| Author(s) : van der Vliet D , Klinkenberg AXY , Platte R , Higgins K , Prokop S , Huizenga MCW , Kraaijevanger L , van Egmond N , Straub VM , Kole MHP , Pacher P , Katona I , Huitinga I , van der Stelt M |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : van der Vliet_2025_bioRxiv__ |
| PubMedID: 40672305 |
| Title : Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research - Hentsch_2025_J.Am.Chem.Soc__ |
| Author(s) : Hentsch A , Guberman M , Radetzki S , Kaushik S , Huizenga M , He Y , Contzen J , Kuhn B , Benz J , Schippers M , Paul J , Leibrock L , Collin L , Wittwer M , Topp A , O'Hara F , Heer D , Hochstrasser R , Blaising J , von Kries JP , Mu L , van der Stelt M , Mergenthaler P , Lipstein N , Grether U , Nazare M |
| Ref : Journal of the American Chemical Society , : , 2025 |
| Abstract : |
| PubMedSearch : Hentsch_2025_J.Am.Chem.Soc__ |
| PubMedID: 40063733 |
| Gene_locus related to this paper: human-MGLL |
| Title : Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research - Hentsch_2025_J.Am.Chem.Soc__ |
| Author(s) : Hentsch A , Guberman M , Radetzki S , Kaushik S , Huizenga M , He Y , Contzen J , Kuhn B , Benz J , Schippers M , Paul J , Leibrock L , Collin L , Wittwer M , Topp A , O'Hara F , Heer D , Hochstrasser R , Blaising J , von Kries JP , Mu L , van der Stelt M , Mergenthaler P , Lipstein N , Grether U , Nazare M |
| Ref : Journal of the American Chemical Society , : , 2025 |
| Abstract : |
| PubMedSearch : Hentsch_2025_J.Am.Chem.Soc__ |
| PubMedID: 40063733 |
| Gene_locus related to this paper: human-MGLL |
| Title : Spatially resolved mapping of monoacylglycerol lipase activity in the brain - van der Vliet_2025_bioRxiv__ |
| Author(s) : van der Vliet D , Klinkenberg AXY , Platte R , Higgins K , Prokop S , Huizenga MCW , Kraaijevanger L , van Egmond N , Straub VM , Kole MHP , Pacher P , Katona I , Huitinga I , van der Stelt M |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : van der Vliet_2025_bioRxiv__ |
| PubMedID: 40672305 |
| Title : Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research - Hentsch_2025_J.Am.Chem.Soc__ |
| Author(s) : Hentsch A , Guberman M , Radetzki S , Kaushik S , Huizenga M , He Y , Contzen J , Kuhn B , Benz J , Schippers M , Paul J , Leibrock L , Collin L , Wittwer M , Topp A , O'Hara F , Heer D , Hochstrasser R , Blaising J , von Kries JP , Mu L , van der Stelt M , Mergenthaler P , Lipstein N , Grether U , Nazare M |
| Ref : Journal of the American Chemical Society , : , 2025 |
| Abstract : |
| PubMedSearch : Hentsch_2025_J.Am.Chem.Soc__ |
| PubMedID: 40063733 |
| Gene_locus related to this paper: human-MGLL |
| Title : PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells - Prokop_2021_Nat.Commun_12_6505 |
| Author(s) : Prokop S , Abranyi-Balogh P , Barti B , Vamosi M , Zoldi M , Barna L , Urban GM , Toth AD , Dudok B , Egyed A , Deng H , Leggio GM , Hunyady L , van der Stelt M , Keseru GM , Katona I |
| Ref : Nat Commun , 12 :6505 , 2021 |
| Abstract : |
| PubMedSearch : Prokop_2021_Nat.Commun_12_6505 |
| PubMedID: 34764251 |
| Gene_locus related to this paper: human-MGLL |
| Title : PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells - Prokop_2021_Nat.Commun_12_6505 |
| Author(s) : Prokop S , Abranyi-Balogh P , Barti B , Vamosi M , Zoldi M , Barna L , Urban GM , Toth AD , Dudok B , Egyed A , Deng H , Leggio GM , Hunyady L , van der Stelt M , Keseru GM , Katona I |
| Ref : Nat Commun , 12 :6505 , 2021 |
| Abstract : |
| PubMedSearch : Prokop_2021_Nat.Commun_12_6505 |
| PubMedID: 34764251 |
| Gene_locus related to this paper: human-MGLL |
| Title : PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells - Prokop_2021_Nat.Commun_12_6505 |
| Author(s) : Prokop S , Abranyi-Balogh P , Barti B , Vamosi M , Zoldi M , Barna L , Urban GM , Toth AD , Dudok B , Egyed A , Deng H , Leggio GM , Hunyady L , van der Stelt M , Keseru GM , Katona I |
| Ref : Nat Commun , 12 :6505 , 2021 |
| Abstract : |
| PubMedSearch : Prokop_2021_Nat.Commun_12_6505 |
| PubMedID: 34764251 |
| Gene_locus related to this paper: human-MGLL |