Nlrp3-IN-33-Cpd12o
NLRP3 (NOD-like receptor pyrin domain-containing protein 3)
General
Type : Acrylate, Feruloyl, Quinoline, Hydroxycinnamic-ester, Multitarget, NLRP3 inflammasome activation
Chemical_Nomenclature : (E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-[(8-hydroxyquinolin-5-yl)amino]-2-oxoethyl]prop-2-enamide
Canonical SMILES : COC1=C(C=CC(=C1)\/C=C\/C(=O)NCC(=O)NC2=C3C=CC=NC3=C(C=C2)O)O
InChI : InChI=1S\/C21H19N3O5\/c1-29-18-11-13(4-7-16(18)25)5-9-19(27)23-12-20(28)24-15-6-8-17(26)21-14(15)3-2-10-22-21\/h2-11,25-26H,12H2,1H3,(H,23,27)(H,24,28)\/b9-5+
InChIKey : BLPGZFNUWGOUOF-WEVVVXLNSA-N
Other name(s) : (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-((8-hydroxyquinolin-5-yl)amino)-2 oxoethyl)acrylamide || Compound 12o || Nlrp3-IN-33 || CHEBI 233294 || HY-162402 || CS-1046595
MW : 393.4
Formula : C21H19N3O5
CAS_number :
PubChem : 171391768
UniChem : BLPGZFNUWGOUOF-WEVVVXLNSA-N
Target
References (1)
| Title : Design, Synthesis, and Biological Evaluation of Ferulic Acid Template-Based Novel Multifunctional Ligands Targeting NLRP3 Inflammasome for the Management of Alzheimer's Disease - Singh_2024_ACS.Chem.Neurosci_15_1388 |
| Author(s) : Singh G , Shankar G , Panda SR , Kumar S , Rai S , Verma H , Kumar P , Nayak PK , Naidu VGM , Srikrishna S , Modi G |
| Ref : ACS Chem Neurosci , 15 :1388 , 2024 |
| Abstract : |
| PubMedSearch : Singh_2024_ACS.Chem.Neurosci_15_1388 |
| PubMedID: 38525886 |