P-Toluenesulfonamide

Building block of cholinesterases multitarget inhibitors (p-tolylsulfonamide moiety binds to the Peripheral Anionic Site) and fluorescent substrate for carboxylesterase (the PTSA targeting the endoplasmic reticulum). Also product of hydrolysis of by polyurethane hydrolysing enzymes

General

Type : Sulfonamide, Sulfur Compound, Benzenesulfonamide

Chemical_Nomenclature : 4-methylbenzenesulfonamide

Canonical SMILES : CC1=CC=C(C=C1)S(=O)(=O)N

InChI : InChI=1S\/C7H9NO2S\/c1-6-2-4-7(5-3-6)11(8,9)10\/h2-5H,1H3,(H2,8,9,10)

InChIKey : LMYRWZFENFIFIT-UHFFFAOYSA-N

Other name(s) : 4-Toluenesulfonamide, Tosylamide, CHEMBL574, CHEBI:34435, SCHEMBL7370, ZINC388056


MW : 171.22

Formula : C7H9NO2S

CAS_number : 70-55-3

PubChem : 6269

UniChem : LMYRWZFENFIFIT-UHFFFAOYSA-N

Target

Families : P-Toluenesulfonamide ligand of proteins in family
Carb_B_Chordata

References (5)

Title : A fast fluorescent probe for tracing endoplasmic reticulum-located carboxylesterase in living cells - Dai_2022_Luminescence__
Author(s) : Dai X , Yu F , Jiang Z , Dong B , Kong X
Ref : Luminescence , : , 2022
PubMedID: 36200455

Title : New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment - Makhaeva_2020_Molecules_25_3915
Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Lushchekina SV , Astakhova TY , Rudakova EV , Proshin AN , Serkov IV , Radchenko EV , Palyulin VA , Bachurin SO , Richardson RJ
Ref : Molecules , 25 :3915 , 2020
PubMedID: 32867324

Title : Enzymatic recycling of thermoplastic polyurethanes: Synergistic effect of an esterase and an amidase and recovery of building blocks - Magnin_2019_Waste.Manag_85_141
Author(s) : Magnin A , Pollet E , Perrin R , Ullmann C , Persillon C , Phalip V , Averous L
Ref : Waste Manag , 85 :141 , 2019
PubMedID: 30803567

Title : Endoplasmic Reticulum Targeting Ratiometric Fluorescent Probe for Carboxylesterase 2 Detection in Drug-Induced Acute Liver Injury - Tian_2019_Anal.Chem_91_15840
Author(s) : Tian X , Yan F , Zheng J , Cui X , Feng L , Li S , Jin L , James TD , Ma X
Ref : Analytical Chemistry , 91 :15840 , 2019
PubMedID: 31713417
Gene_locus related to this paper: human-CES2

Title : Conjugates of Tacrine and Its Cyclic Homologues with p-Toluenesulfonamide as Novel Acetylcholinesterase and Butyrylcholinesterase Inhibitors - Makhaeva_2018_Dokl.Biochem.Biophys_483_369
Author(s) : Makhaeva GF , Kovaleva NV , Lushchekina SV , Rudakova EV , Boltneva NP , Proshin AN , Lednev BV , Serkov IV , Bachurin SO
Ref : Dokl Biochem Biophys , 483 :369 , 2018
PubMedID: 30607741