Rivastigmine
Rivastigmine Exelon: a carbamate-derived reversible cholinesterase inhibitor (both butyrylcholinesterase and acetylcholinesterase) that is selective for the central nervous system and is used for the treatment of dementia in ALzheimer disease and Parkinson disease
General
Type : Derivative of Rivastigmine, Stigmine, Carbamate, Drug
Chemical_Nomenclature : S-N-ethyl-3-[(1-dimethyl-amino)ethyl]-N-methyl-phenylcarbamate hydrogentartrate
Canonical SMILES : CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C
InChI : InChI=1S\/C14H22N2O2\/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4\/h7-11H,6H2,1-5H3 || InChI=1S\/C14H22N2O2\/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4\/h7-11H,6H2,1-5H3\/t11-\/m0\/s1
InChIKey : XSVMFMHYUFZWBK-UHFFFAOYSA-N || XSVMFMHYUFZWBK-NSHDSACASA-N
Other name(s) : carbamoylatine || Exelon || ENA-713 || SDZ-212-713 || SDZ-ENA-713 || SDZ-ENA713 || ENA-713~Rivastigmine
MW : 250.34
Formula : C14H22N2O2
CAS_number : 123441-03-2, 129101-54-8
UniChem : XSVMFMHYUFZWBK-UHFFFAOYSA-N, XSVMFMHYUFZWBK-NSHDSACASA-N
IUPHAR : 6602
Wikipedia : Rivastigmine
Target
Families : Rivastigmine ligand of proteins in family
ACHE
Protein :
torca-ACHE
References (17)
| Title : Molecular Mechanisms of Neurodegeneration: A Focus on Cholinergic Dysfunction and the Therapeutic Potential of Rivastigmine Derivatives - Singh_2026_Curr.Top.Med.Chem__ |
| Author(s) : Singh K , Sethi P , Jain D , Gupta JK , Waqar Z , Singh B , Syed R , Tabish M , Sharma MC |
| Ref : Curr Top Med Chem , : , 2026 |
| Abstract : |
| PubMedSearch : Singh_2026_Curr.Top.Med.Chem__ |
| PubMedID: 42152708 |
| Title : Covalent Ligand-AChE Adduct is a Bidirectional Indicator for Either Ligand or AChE: Pesticides as the Case - Zhang_2026_Anal.Chem__ |
| Author(s) : Zhang K , Li T , Li J , Li H , Dong F , Zhao H , Gu X , Song Y |
| Ref : Analytical Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Zhang_2026_Anal.Chem__ |
| PubMedID: 42275633 |
| Title : Successful resolution of Capgras syndrome with rivastigmine treatment in Lewy body dementia - Sultan_2025_BMJ.Case.Rep_18_ |
| Author(s) : Sultan R , Bouhenni R , Sasse J , Balachandran S |
| Ref : BMJ Case Rep , 18 : , 2025 |
| Abstract : |
| PubMedSearch : Sultan_2025_BMJ.Case.Rep_18_ |
| PubMedID: 41224365 |
| Title : Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease - Robinson_2025_Behav.Pharmacol__ |
| Author(s) : Robinson L , Bray J , Melis V , Harrington CR , Wischik CM , Riedel G |
| Ref : Behav Pharmacol , : , 2025 |
| Abstract : |
| PubMedSearch : Robinson_2025_Behav.Pharmacol__ |
| PubMedID: 41396167 |
| Title : Effects of rivastigmine on gait in patients with neurodegenerative disorders: A systematic review and meta-analysis - Shim_2024_PLoS.One_19_e0310900 |
| Author(s) : Shim SR , Kim JY , Kwon KY , Shin J , Lee Y , Lee SM |
| Ref : PLoS ONE , 19 :e0310900 , 2024 |
| Abstract : |
| PubMedSearch : Shim_2024_PLoS.One_19_e0310900 |
| PubMedID: 39666629 |
| Title : Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors - Tsurkan_2013_Chem.Biol.Interact_203_226 |
| Author(s) : Tsurkan LG , Hatfield MJ , Edwards CC , Hyatt JL , Potter PM |
| Ref : Chemico-Biological Interactions , 203 :226 , 2013 |
| Abstract : |
| PubMedSearch : Tsurkan_2013_Chem.Biol.Interact_203_226 |
| PubMedID: 23123248 |
| Title : Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine - Bar-On_2002_Biochemistry_41_3555 |
| Author(s) : Bar-On P , Millard CB , Harel M , Dvir H , Enz A , Sussman JL , Silman I |
| Ref : Biochemistry , 41 :3555 , 2002 |
| Abstract : |
| PubMedSearch : Bar-On_2002_Biochemistry_41_3555 |
| PubMedID: 11888271 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Alzheimer's disease: seeking new ways to preserve brain function. Interview by Alice V. Luddington - Davis_1999_Geriatrics_54_42 |
| Author(s) : Davis KL |
| Ref : Geriatrics , 54 :42 , 1999 |
| Abstract : |
| PubMedSearch : Davis_1999_Geriatrics_54_42 |
| PubMedID: 10024872 |
| Title : Dose-dependent CSF acetylcholinesterase inhibition by SDZ ENA 713 in Alzheimer's disease - Cutler_1998_Acta.Neurol.Scand_97_244 |
| Author(s) : Cutler NR , Polinsky RJ , Sramek JJ , Enz A , Jhee SS , Mancione L , Hourani J , Zolnouni P |
| Ref : Acta Neurologica Scandinavica , 97 :244 , 1998 |
| Abstract : |
| PubMedSearch : Cutler_1998_Acta.Neurol.Scand_97_244 |
| PubMedID: 9576639 |
| Title : Disposition of SDZ ENA 713, an acetylcholinesterase inhibitor, in the rabbit - Habucky_1998_Biopharm.Drug.Dispos_19_285 |
| Author(s) : Habucky K , Tse FL |
| Ref : Biopharmaceutics & Drug Disposition , 19 :285 , 1998 |
| Abstract : |
| PubMedSearch : Habucky_1998_Biopharm.Drug.Dispos_19_285 |
| PubMedID: 9673779 |
| Title : Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease - Polinsky_1998_Clin.Ther_20_634 |
| Author(s) : Polinsky RJ |
| Ref : Clin Ther , 20 :634 , 1998 |
| Abstract : |
| PubMedSearch : Polinsky_1998_Clin.Ther_20_634 |
| PubMedID: 9737824 |
| Title : Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications - Giacobini_1998_Neurochem.Int_32_413 |
| Author(s) : Giacobini E |
| Ref : Neurochem Int , 32 :413 , 1998 |
| Abstract : |
| PubMedSearch : Giacobini_1998_Neurochem.Int_32_413 |
| PubMedID: 9676739 |
| Title : Cerebro-protective effects of ENA713, a novel acetylcholinesterase inhibitor, in closed head injury in the rat - Chen_1998_Brain.Res_784_18 |
| Author(s) : Chen Y , Shohami E , Bass R , Weinstock M |
| Ref : Brain Research , 784 :18 , 1998 |
| Abstract : |
| PubMedSearch : Chen_1998_Brain.Res_784_18 |
| PubMedID: 9518537 |
| Title : Rivastigmine, a brain-selective acetylcholinesterase inhibitor, ameliorates cognitive and motor deficits induced by closed-head injury in the mouse - Chen_1998_J.Neurotrauma_15_231 |
| Author(s) : Chen Y , Shohami E , Constantini S , Weinstock M |
| Ref : Journal of Neurotrauma , 15 :231 , 1998 |
| Abstract : |
| PubMedSearch : Chen_1998_J.Neurotrauma_15_231 |
| PubMedID: 9555969 |
| Title : Treating Alzheimer's disease.Pharmacologic options now and in the near future - Tariot_1997_Postgrad.Med_101_73 |
| Author(s) : Tariot PN , Schneider L , Porsteinsson AP |
| Ref : Postgrad Med , 101 :73 , 1997 |
| Abstract : |
| PubMedSearch : Tariot_1997_Postgrad.Med_101_73 |
| PubMedID: 9194867 |
| Title : Inhibition of acetylcholinesterase modulates the autoregulation of cerebral blood flow and attenuates ischemic brain metabolism in hypertensive rats - Sadoshima_1995_J.Cerebral.Blood.Flow.Metab_15_845 |
| Author(s) : Sadoshima S , Ibayashi S , Fujii K , Nagao T , Sugimori H , Fujishima M |
| Ref : Journal of Cerebral Blood Flow & Metabolism , 15 :845 , 1995 |
| Abstract : |
| PubMedSearch : Sadoshima_1995_J.Cerebral.Blood.Flow.Metab_15_845 |
| PubMedID: 7673377 |
| Title : Post-ischemic administration of the acetylcholinesterase inhibitor ENA-713 prevents delayed neuronal death in the gerbil hippocampus - Tanaka_1995_Neurochem.Res_20_663 |
| Author(s) : Tanaka K , Mizukawa K , Ogawa N , Mori A |
| Ref : Neurochemical Research , 20 :663 , 1995 |
| Abstract : |
| PubMedSearch : Tanaka_1995_Neurochem.Res_20_663 |
| PubMedID: 756636 |