Sulfapyridine
Not inhibitor of Notum. Compound 11 Fragment 151 IC50 >1000 microM. Sulfapyridine is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine. Its manufacture and use were discontinued in 1990
General
Type : Fragment inhibitor of Notum, Sulfonamide, Sulfur Compound, Antibiotic, Pyridine, Not AlphaBeta Hydrolase target, Benzenesulfonamide
Chemical_Nomenclature : 4-amino-N-pyridin-2-ylbenzenesulfonamide
Canonical SMILES : C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI : InChI=1S\/C11H11N3O2S\/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11\/h1-8H,12H2,(H,13,14)
InChIKey : GECHUMIMRBOMGK-UHFFFAOYSA-N
Other name(s) : Fragment 151 || Fragment-151 || SFY || DB00891 || Sulphapyridine || 2-Sulfapyridine || Sulfidin || CHEBI:132842 || CHEMBL700 || Oprea1_344996 || SCHEMBL44219 || ZINC2105
MW : 249.29
Formula : C11H11N3O2S
CAS_number : 144-83-2
PubChem : 5336
UniChem : GECHUMIMRBOMGK-UHFFFAOYSA-N
Target
Families : Sulfapyridine ligand of proteins in family
Pectinacetylesterase-Notum
Structure :
7B8D
Protein :
human-NOTUM
References (1)
| Title : Structural Analysis and Development of Notum Fragment Screening Hits - Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| Author(s) : Zhao Y , Mahy W , Willis NJ , Woodward HL , Steadman D , Bayle ED , Atkinson BN , Sipthorp J , Vecchia L , Ruza RR , Harlos K , Jeganathan F , Constantinou S , Costa A , Kjaer S , Bictash M , Salinas PC , Whiting P , Vincent JP , Fish PV , Jones EY |
| Ref : ACS Chem Neurosci , 13 :2060 , 2022 |
| Abstract : |
| PubMedSearch : Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| PubMedID: 35731924 |
| Gene_locus related to this paper: human-NOTUM |