Antibiotic

General

Antimicrobial substance active against bacteria. Target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Protein synthesis inhibitors (macrolides, lincosamides, and tetracyclines) are usually bacteriostatic (with the exception of bactericidal aminoglycosides). Some alpha/beta hydrolases are involved in the biosynthesis or the activation or hydrolysis of these compounds
Inhibitor Main targeted enzyme families Type Structure
Meropenem ACPH_Peptidase_S9 Antibiotic Pyrrolidine Carboxamide Drug Sulfur Compound Azabicyclo
Sulfapyridine Pectinacetylesterase-Notum Fragment inhibitor of Notum Sulfonamide Sulfur Compound Antibiotic Pyridine Not AlphaBeta Hydrolase target Benzenesulfonamide
DCMAT Aclacinomycin-methylesterase_RdmC Antibiotic Glycoside
DCMAA Aclacinomycin-methylesterase_RdmC Antibiotic Glycoside
Mevastatin Carboxylesterase Carb_B_Chordata Drug Natural Not AlphaBeta Hydrolase target Naphthalen Antibiotic
Meropenem ACPH_Peptidase_S9 Antibiotic Pyrrolidine Carboxamide Drug Sulfur compound Azabicyclo
Sulfapyridine Pectinacetylesterase-Notum Fragment inhibitor of Notum Sulfonamide Sulfur compound Antibiotic Pyridine Not AlphaBeta Hydrolase target Benzenesulfonamide
DCMAT Aclacinomycin-methylesterase_RdmC Antibiotic Glycoside
DCMAA Aclacinomycin-methylesterase_RdmC Antibiotic Glycoside
Mevastatin Carboxylesterase Carb_B_Chordata Drug Natural Not AlphaBeta Hydrolase target Naphthalen Antibiotic
Meropenem ACPH_Peptidase_S9 Antibiotic Pyrrolidine Carboxamide Drug Sulfur compound Azabicyclo
Sulfapyridine Pectinacetylesterase-Notum Fragment inhibitor of Notum Sulfonamide Sulfur compound Antibiotic Pyridine Not AlphaBeta Hydrolase target Benzenesulfonamide
DCMAT Aclacinomycin-methylesterase_RdmC Antibiotic Glycoside
DCMAA Aclacinomycin-methylesterase_RdmC Antibiotic Glycoside
Mevastatin Carboxylesterase Carb_B_Chordata Drug Natural Not AlphaBeta Hydrolase target Naphthalen Antibiotic