Tacrine(8)-4-aminoquinoline

General

Type : Derivative of Tacrine, Quinoline, Alkyl linked bis-ligand

Chemical_Nomenclature : N-quinolin-4-yl-N'-(1,2,3,4-tetrahydroacridin-9-yl)octane-1,8-diamine

Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)NCCCCCCCCNC4=CC=NC5=CC=CC=C54

InChI : InChI=1S\/C30H36N4\/c1(3-11-20-31-27-19-22-32-26-16-8-5-13-23(26)27)2-4-12-21-33-30-24-14-6-9-17-28(24)34-29-18-10-7-15-25(29)30\/h5-6,8-9,13-14,16-17,19,22H,1-4,7,10-12,15,18,20-21H2,(H,31,32)(H,33,34)

InChIKey : UNVOAAWEEGAXTN-UHFFFAOYSA-N

Other name(s) : CHEMBL1082738e  ||  A8Be  ||  AC1LCVTYe  ||  BDBM9441e  ||  ZINC12504439


MW : 452.63

Formula : C30H36N4

CAS_number :

PubChem : 656986

UniChem : UNVOAAWEEGAXTN-UHFFFAOYSA-N

Target

Families : Tacrine(8)-4-aminoquinoline ligand of proteins in family
ACHE

Structure :
1ODC

Protein :
torca-ACHE

References (1)

Title : Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge - Rydberg_2006_J.Med.Chem_49_5491
Author(s) : Rydberg EH , Brumshtein B , Greenblatt HM , Wong DM , Shaya D , Williams LD , Carlier PR , Pang YP , Silman I , Sussman JL
Ref : Journal of Medicinal Chemistry , 49 :5491 , 2006
Abstract :
PubMedSearch : Rydberg_2006_J.Med.Chem_49_5491
PubMedID: 16942022
Gene_locus related to this paper: torca-ACHE