Tacrine-hydrazono-triazol-phenyl-trifluoromethyl-pyrazol-benzenesulfonamide-Cpd10b
BuChE, IC50: 470 nM, potent COX-2 inhibitory activity (IC50: 50 nM), and low nanomolar Ki towards human carbonic anhydrase IX (hCA IX) Tacrine-celecoxib hybrid. Celecoxib CID 2662 methylphenyl-trifluoromethylpyrazol-benzenesulfonamide
General
Type : Multitarget, Pyrazole, Triazol, Trifluoro, Dimethoxyphenyl, Carbonic anhydrase inhibitor, Sulfur Compound, Sulfonamide, Cyclooxygenase-2 Inhibitor, Derivative of Tacrine, Acridine
Chemical_Nomenclature : (E)-4-(5-(4-(4-((2-methoxy-4-((2-(1,2,3,4-tetrahydroacridin-9-yl)hydrazono) methyl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide hydrochloride
Canonical SMILES : C18=C(C(=C2C(=[N+]1)C=CC=C2)NN=CC3=CC=C(C(=C3)OC)OCC4=C[N](N=N4)C5=CC=C(C=C5)C6=CC(=N[N]6C7=CC=C(C=C7)[S](=O)(=O)N)C(F)(F)F)CCCC8
InChI : 1S\/C40H34F3N9O4S\/c1-55-37-20-25(22-45-48-39-31-6-2-4-8-33(31)46-34-9-5-3-7-32(34)39)10-19-36(37)56-24-27-23-51(50-47-27)28-13-11-26(12-14-28)35-21-38(40(41,42)43)49-52(35)29-15-17-30(18-16-29)57(44,53)54\/h2,4,6,8,10-23H,3,5,7,9,24H2,1H3,(H,46,48)(H2,44,53,54)\/p+1
InChIKey : FFCUTQWMQHJQDE-UHFFFAOYSA-O
Other name(s) : Compound 10b
Target
Families : Tacrine-hydrazono-triazol-phenyl-trifluoromethyl-pyrazol-benzenesulfonamide-Cpd10b ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : One destination, three routes: Tacrine-Celecoxib hybrids targeting cholinesterases, COX-2, and carbonic anhydrases in cognitive impairment linked to metabolic dysfunction - Hassan_2026_Eur.J.Med.Chem_315_118984 |
| Author(s) : Hassan NW , Afifi OS , El-Attar MAZ , Kamel YN , Yassin HA , Nomeir HM , Angeli A , Labib HF , Elsheikh MA , Zewail M , Gerges EM , El-Yazbi AF , Spagnuolo R , Naldi M , Ashmawy MI , Zahra WK , Hammad SF , Supuran CT , Bartolini M , Elzahhar PA , Belal ASF , Abd El Wahab SM |
| Ref : Eur Journal of Medicinal Chemistry , 315 :118984 , 2026 |
| Abstract : |
| PubMedSearch : Hassan_2026_Eur.J.Med.Chem_315_118984 |
| PubMedID: 42190432 |