Verbascoside
The glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid. It has a role as a neuroprotective agent, an antileishmanial agent, an anti-inflammatory agent, a plant metabolite and an antibacterial agent. Inhibitor of Prolyl Oligopeptidase
General
Type : Natural, Hydroxycinnamic-ester, Alkaloid, Glycoside, Dihydroxyphenyl, Antioxidant
Chemical_Nomenclature : [(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Canonical SMILES : C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H](O[C@@H]([C@H]2OC(=O)\/C=C\/C3=CC(=C(C=C3)O)O)CO)OCCC4=CC(=C(C=C4)O)O)O)O)O)O
InChI : InChI=1S\/C29H36O15\/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14\/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3\/b7-4+\/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29-\/m0\/s1
InChIKey : FBSKJMQYURKNSU-ZLSOWSIRSA-N
Other name(s) : Acteoside || Kusaginin || TJC 160 || CHEBI:132853 || SCHEMBL657970 || CHEMBL231853 || CHEMBL444478 || SCHEMBL29485048 || SCHEMBL29499087 || SCHEMBL29626822 || DB12996
MW : 624.6
Formula : C29H36O15
CAS_number : 61276-17-3
PubChem : 5281800
UniChem : FBSKJMQYURKNSU-ZLSOWSIRSA-N
Target
Families : Verbascoside ligand of proteins in family
S9N_PPCE_Peptidase_S9
Pancreatic_lipase
Protein :
human-PREP
human-PNLIP
References (21)
| Title : Comprehensive analysis of Leonotis nepetifolia flower extracts: phytochemical composition and toxicity in zebrafish embryos - Adolpho_2025_Nat.Prod.Res__1 |
| Author(s) : Adolpho L , Portalanza D , Ames J , Casoti R , Loro VL , Morel AF , Dalcol, II |
| Ref : Nat Prod Res , :1 , 2025 |
| Abstract : |
| PubMedSearch : Adolpho_2025_Nat.Prod.Res__1 |
| PubMedID: 39878299 |
| Title : Chemical Characterization, Antioxidant and Enzyme-Inhibitory Activities of Different Extracts from Three Phlomis Species - Yagi_2025_ChemistryOpen__e2500004 |
| Author(s) : Yagi S , Zengin G , Cetiz MV , Cziaky Z , Jeko J , Bahsi M , Cakilcioglu U , Turumtay H , Aktumsek A |
| Ref : ChemistryOpen , :e2500004 , 2025 |
| Abstract : |
| PubMedSearch : Yagi_2025_ChemistryOpen__e2500004 |
| PubMedID: 40351016 |
| Title : Insights into the dual inhibitory effects of phenylethanoid glycosides from Osmanthus fragrans flower on glycolipid metabolizing enzymes - Li_2025_Bioorg.Chem_168_109328 |
| Author(s) : Li W , Qiu G , Kang M , Zhang C , Quan W , Zhou H , Fan X , Luo J , Lu B , Li M |
| Ref : Bioorg Chem , 168 :109328 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_Bioorg.Chem_168_109328 |
| PubMedID: 41401698 |
| Title : Chemical Composition and Bioactivities of Sideritis libanotica Labill subsp. Libanotica: LC-HRMS Phytochemical Profiling, Mineral Content, Antioxidant, Antibacterial, and Neuroprotective-Antidiabetic Enzyme Inhibitory Potentials - Ozturk_2025_Chem.Biodivers__e01314 |
| Author(s) : Ozturk Sarikaya SB , Zehiroglu C |
| Ref : Chem Biodivers , :e01314 , 2025 |
| Abstract : |
| PubMedSearch : Ozturk_2025_Chem.Biodivers__e01314 |
| PubMedID: 40961453 |
| Title : Comprehensive analysis of Leonotis nepetifolia flower extracts: phytochemical composition and toxicity in zebrafish embryos - Adolpho_2025_Nat.Prod.Res__1 |
| Author(s) : Adolpho L , Portalanza D , Ames J , Casoti R , Loro VL , Morel AF , Dalcol, II |
| Ref : Nat Prod Res , :1 , 2025 |
| Abstract : |
| PubMedSearch : Adolpho_2025_Nat.Prod.Res__1 |
| PubMedID: 39878299 |
| Title : Chemical Characterization, Antioxidant and Enzyme-Inhibitory Activities of Different Extracts from Three Phlomis Species - Yagi_2025_ChemistryOpen__e2500004 |
| Author(s) : Yagi S , Zengin G , Cetiz MV , Cziaky Z , Jeko J , Bahsi M , Cakilcioglu U , Turumtay H , Aktumsek A |
| Ref : ChemistryOpen , :e2500004 , 2025 |
| Abstract : |
| PubMedSearch : Yagi_2025_ChemistryOpen__e2500004 |
| PubMedID: 40351016 |
| Title : Insights into the dual inhibitory effects of phenylethanoid glycosides from Osmanthus fragrans flower on glycolipid metabolizing enzymes - Li_2025_Bioorg.Chem_168_109328 |
| Author(s) : Li W , Qiu G , Kang M , Zhang C , Quan W , Zhou H , Fan X , Luo J , Lu B , Li M |
| Ref : Bioorg Chem , 168 :109328 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_Bioorg.Chem_168_109328 |
| PubMedID: 41401698 |
| Title : Chemical Composition and Bioactivities of Sideritis libanotica Labill subsp. Libanotica: LC-HRMS Phytochemical Profiling, Mineral Content, Antioxidant, Antibacterial, and Neuroprotective-Antidiabetic Enzyme Inhibitory Potentials - Ozturk_2025_Chem.Biodivers__e01314 |
| Author(s) : Ozturk Sarikaya SB , Zehiroglu C |
| Ref : Chem Biodivers , :e01314 , 2025 |
| Abstract : |
| PubMedSearch : Ozturk_2025_Chem.Biodivers__e01314 |
| PubMedID: 40961453 |
| Title : Comprehensive analysis of Leonotis nepetifolia flower extracts: phytochemical composition and toxicity in zebrafish embryos - Adolpho_2025_Nat.Prod.Res__1 |
| Author(s) : Adolpho L , Portalanza D , Ames J , Casoti R , Loro VL , Morel AF , Dalcol, II |
| Ref : Nat Prod Res , :1 , 2025 |
| Abstract : |
| PubMedSearch : Adolpho_2025_Nat.Prod.Res__1 |
| PubMedID: 39878299 |
| Title : Chemical Characterization, Antioxidant and Enzyme-Inhibitory Activities of Different Extracts from Three Phlomis Species - Yagi_2025_ChemistryOpen__e2500004 |
| Author(s) : Yagi S , Zengin G , Cetiz MV , Cziaky Z , Jeko J , Bahsi M , Cakilcioglu U , Turumtay H , Aktumsek A |
| Ref : ChemistryOpen , :e2500004 , 2025 |
| Abstract : |
| PubMedSearch : Yagi_2025_ChemistryOpen__e2500004 |
| PubMedID: 40351016 |
| Title : Insights into the dual inhibitory effects of phenylethanoid glycosides from Osmanthus fragrans flower on glycolipid metabolizing enzymes - Li_2025_Bioorg.Chem_168_109328 |
| Author(s) : Li W , Qiu G , Kang M , Zhang C , Quan W , Zhou H , Fan X , Luo J , Lu B , Li M |
| Ref : Bioorg Chem , 168 :109328 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_Bioorg.Chem_168_109328 |
| PubMedID: 41401698 |
| Title : Chemical Composition and Bioactivities of Sideritis libanotica Labill subsp. Libanotica: LC-HRMS Phytochemical Profiling, Mineral Content, Antioxidant, Antibacterial, and Neuroprotective-Antidiabetic Enzyme Inhibitory Potentials - Ozturk_2025_Chem.Biodivers__e01314 |
| Author(s) : Ozturk Sarikaya SB , Zehiroglu C |
| Ref : Chem Biodivers , :e01314 , 2025 |
| Abstract : |
| PubMedSearch : Ozturk_2025_Chem.Biodivers__e01314 |
| PubMedID: 40961453 |
| Title : Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity - Romero-Marquez_2024_Food.Chem_444_138516 |
| Author(s) : Romero-Marquez JM , Navarro-Hortal MD , Forbes-Hernandez TY , Varela-Lopez A , Puentes JG , Sanchez-Gonzalez C , Sumalla-Cano S , Battino M , Garcia-Ruiz R , Sanchez S , Quiles JL |
| Ref : Food Chem , 444 :138516 , 2024 |
| Abstract : |
| PubMedSearch : Romero-Marquez_2024_Food.Chem_444_138516 |
| PubMedID: 38306771 |
| Title : Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity - Romero-Marquez_2024_Food.Chem_444_138516 |
| Author(s) : Romero-Marquez JM , Navarro-Hortal MD , Forbes-Hernandez TY , Varela-Lopez A , Puentes JG , Sanchez-Gonzalez C , Sumalla-Cano S , Battino M , Garcia-Ruiz R , Sanchez S , Quiles JL |
| Ref : Food Chem , 444 :138516 , 2024 |
| Abstract : |
| PubMedSearch : Romero-Marquez_2024_Food.Chem_444_138516 |
| PubMedID: 38306771 |
| Title : Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity - Romero-Marquez_2024_Food.Chem_444_138516 |
| Author(s) : Romero-Marquez JM , Navarro-Hortal MD , Forbes-Hernandez TY , Varela-Lopez A , Puentes JG , Sanchez-Gonzalez C , Sumalla-Cano S , Battino M , Garcia-Ruiz R , Sanchez S , Quiles JL |
| Ref : Food Chem , 444 :138516 , 2024 |
| Abstract : |
| PubMedSearch : Romero-Marquez_2024_Food.Chem_444_138516 |
| PubMedID: 38306771 |
| Title : Phytochemical study of Lantana camara flowers, ecotoxicity, antioxidant, in vitro and in silico acetylcholinesterase: molecular docking, MD, and MM\/GBSA calculations - da Fonseca_2022_J.Biomol.Struct.Dyn__1 |
| Author(s) : da Fonseca AM , Luthierre Gama Cavalcante A , Mendes A , da Silva F , Ferreira DCL , Ribeiro PRV , Dos Santos JCS , Dos Santos HS , Gaieta EM , Marinho GS , Colares RP , Marinho ES |
| Ref : J Biomol Struct Dyn , :1 , 2022 |
| Abstract : |
| PubMedSearch : da Fonseca_2022_J.Biomol.Struct.Dyn__1 |
| PubMedID: 36326114 |
| Title : Phytochemical study of Lantana camara flowers, ecotoxicity, antioxidant, in vitro and in silico acetylcholinesterase: molecular docking, MD, and MM\/GBSA calculations - da Fonseca_2022_J.Biomol.Struct.Dyn__1 |
| Author(s) : da Fonseca AM , Luthierre Gama Cavalcante A , Mendes A , da Silva F , Ferreira DCL , Ribeiro PRV , Dos Santos JCS , Dos Santos HS , Gaieta EM , Marinho GS , Colares RP , Marinho ES |
| Ref : J Biomol Struct Dyn , :1 , 2022 |
| Abstract : |
| PubMedSearch : da Fonseca_2022_J.Biomol.Struct.Dyn__1 |
| PubMedID: 36326114 |
| Title : Phytochemical study of Lantana camara flowers, ecotoxicity, antioxidant, in vitro and in silico acetylcholinesterase: molecular docking, MD, and MM\/GBSA calculations - da Fonseca_2022_J.Biomol.Struct.Dyn__1 |
| Author(s) : da Fonseca AM , Luthierre Gama Cavalcante A , Mendes A , da Silva F , Ferreira DCL , Ribeiro PRV , Dos Santos JCS , Dos Santos HS , Gaieta EM , Marinho GS , Colares RP , Marinho ES |
| Ref : J Biomol Struct Dyn , :1 , 2022 |
| Abstract : |
| PubMedSearch : da Fonseca_2022_J.Biomol.Struct.Dyn__1 |
| PubMedID: 36326114 |
| Title : Inhibitory Effect of Verbascoside Isolated from Buddleja brasiliensis Jacq. ex Spreng on Prolyl Oligopeptidase Activity - Filho_2012_Phytother.Res_26_1472 |
| Author(s) : Filho AG , Morel AF , Adolpho L , Ilha V , Giralt E , Tarrago T , Dalcol II |
| Ref : Phytother Res , 26 :1472 , 2012 |
| Abstract : |
| PubMedSearch : Filho_2012_Phytother.Res_26_1472 |
| PubMedID: 22275311 |
| Gene_locus related to this paper: human-PREP |
| Title : Inhibitory Effect of Verbascoside Isolated from Buddleja brasiliensis Jacq. ex Spreng on Prolyl Oligopeptidase Activity - Filho_2012_Phytother.Res_26_1472 |
| Author(s) : Filho AG , Morel AF , Adolpho L , Ilha V , Giralt E , Tarrago T , Dalcol II |
| Ref : Phytother Res , 26 :1472 , 2012 |
| Abstract : |
| PubMedSearch : Filho_2012_Phytother.Res_26_1472 |
| PubMedID: 22275311 |
| Gene_locus related to this paper: human-PREP |
| Title : Inhibitory Effect of Verbascoside Isolated from Buddleja brasiliensis Jacq. ex Spreng on Prolyl Oligopeptidase Activity - Filho_2012_Phytother.Res_26_1472 |
| Author(s) : Filho AG , Morel AF , Adolpho L , Ilha V , Giralt E , Tarrago T , Dalcol II |
| Ref : Phytother Res , 26 :1472 , 2012 |
| Abstract : |
| PubMedSearch : Filho_2012_Phytother.Res_26_1472 |
| PubMedID: 22275311 |
| Gene_locus related to this paper: human-PREP |