YH168
(IC50= 12 nM) developped as a reversible MAGL PET probe ((R)-YH134 18F-radiolabeling F instead of CH3)
General
Type : Pyrrolidine, Piperazine, PET probe
Chemical_Nomenclature :
Canonical SMILES : O=C1C[C@@H](CN1C3=CC=C(C2=CC=CC(=C2)C)C=C3)N5CCN(C(C4=CC=CO4)=O)CC5
InChI : InChI=1S\/C26H27N3O3\/c1-19-4-2-5-21(16-19)20-7-9-22(10-8-20)29-18-23(17-25(29)30)27-11-13-28(14-12-27)26(31)24-6-3-15-32-24\/h2-10,15-16,23H,11-14,17-18H2,1H3\/t23-\/m0\/s1
InChIKey : HINVMJBSOHPONM-QHCPKHFHSA-N
Other name(s) : (R)-[11C]YH168
Target
Families : YH168 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : Exploration of (R)-[(11)C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates - He_2024_Eur.J.Nucl.Med.Mol.Imaging__ |
| Author(s) : He Y , Zheng M , Gu J , Reichert L , Trimborn J , Zhang H , Keller C , Crosby M , Collin L , Heer D , Pavlovic A , Topp A , Wittwer MB , Grether U , Gobbi L , Schibli R , Huang Y , Mu L |
| Ref : Eur J Nucl Med Mol Imaging , : , 2024 |
| Abstract : |
| PubMedSearch : He_2024_Eur.J.Nucl.Med.Mol.Imaging__ |
| PubMedID: 39673602 |