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Inhibitor Report for: WWL50

Carbamate inhibitor of mouse CES1 The fluoride compound is WWL50, without fluoride CHEMBL77270 CID 306692



General
Type: Carbamate
Chemical_Nomenclature: 4-fluoro-3-methylphenyl cyclohexylcarbamate
Canonical SMILES: CC1=CC(=CC=C1)OC(=O)NC2CCCCC2
InChI: InChI=1S/C14H19NO2/c1-11-6-5-9-13(10-11)17-14(16)15-12-7-3-2-4-8-12/h5-6,9-10,12H,2-4,7-8H2,1H3,(H,15,16)
InChIKey: HVJIDJLSBZMPDP-UHFFFAOYSA-N
Other name(s): CHEMBL77270 ; NSC204378 ; ZINC1738990 ; BDBM50128584 ; Cyclohexyl-carbamic acid m-tolyl ester
MW: 251.30
Formula: C14H18FNO2
CAS_number:
PubChem: 306692
IUPHAR:
Wikipedia:

Target families
WWL50 ligand of proteins in family: Carb_B_Chordata
No structure

References
Search PubMed for references concerning: WWL50
    Title: Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes
    Xu H, Majmudar JD, Davda D, Ghanakota P, Kim KH, Carlson HA, Showalter HD, Martin BR, Amidon GL
    Ref: Mol Pharm, 12:3399, 2015 : PubMed

            

    Title: Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening
    Bachovchin DA, Ji T, Li W, Simon GM, Blankman JL, Adibekian A, Hoover H, Niessen S, Cravatt BF
    Ref: Proc Natl Acad Sci U S A, 107:20941, 2010 : PubMed

            

    Title: Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors
    Tarzia G, Duranti A, Tontini A, Piersanti G, Mor M, Rivara S, Plazzi PV, Park C, Kathuria S, Piomelli D
    Ref: Journal of Medicinal Chemistry, 46:2352, 2003 : PubMed