Gene Locus : mouse-3neur
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Site directed mutagenesis R451C substitution in neuroligin-3 R451C mutant mice showed impaired social interactions but enhanced spatial learning abilities Tabuchi_2007_Science_318_71
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification :
Torpedo_number : 388
Kinetic Parameter : No kinetic parameter
News : DECEMBER-12-2007
Comment :
| Title : Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in the Nlgn3(R451C) Mouse Model of Autism - Hosie_2024_Int.J.Mol.Sci_25_ |
| Author(s) : Hosie S , Abo-Shaban T , Mou K , Balasuriya GK , Mohsenipour M , Alamoudi MU , Filippone RT , Belz GT , Franks AE , Bornstein JC , Nurgali K , Hill-Yardin EL |
| Ref : Int J Mol Sci , 25 : , 2024 |
| Abstract : |
| PubMedSearch : Hosie_2024_Int.J.Mol.Sci_25_ |
| PubMedID: 38255906 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation - Diamanti_2024_Traffic_25_e12930 |
| Author(s) : Diamanti T , Trobiani L , Mautone L , Serafini F , Gioia R , Ferrucci L , Lauro C , Bianchi S , Perfetto C , Guglielmo S , Sollazzo R , Giorda E , Setini A , Ragozzino D , Miranda E , Comoletti D , Di Angelantonio S , Cacci E , De Jaco A |
| Ref : Traffic , 25 :e12930 , 2024 |
| Abstract : |
| PubMedSearch : Diamanti_2024_Traffic_25_e12930 |
| PubMedID: 38272450 |
| Gene_locus related to this paper: human-NLGN3 , mouse-3neur |
| Title : Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task - Li_2024_Psychopharmacology.(Berl)__ |
| Author(s) : Li S , May C , Pang TY , Churilov L , Hannan AJ , Johnson KA , Burrows EL |
| Ref : Psychopharmacology (Berl) , : , 2024 |
| Abstract : |
| PubMedSearch : Li_2024_Psychopharmacology.(Berl)__ |
| PubMedID: 38170320 |
| Gene_locus related to this paper: human-NLGN3 , mouse-3neur |
| Title : Impaired cecal motility and secretion alongside expansion of gut-associated lymphoid tissue in the Nlgn3(R451C) mouse model of autism - Lee_2023_Sci.Rep_13_12687 |
| Author(s) : Lee CYQ , Balasuriya GK , Herath M , Franks AE , Hill-Yardin EL |
| Ref : Sci Rep , 13 :12687 , 2023 |
| Abstract : |
| PubMedSearch : Lee_2023_Sci.Rep_13_12687 |
| PubMedID: 37542090 |
| Gene_locus related to this paper: mouse-3neur |
| Title : NMDA receptor hypofunction underlies deficits in parvalbumin interneurons and social behavior in neuroligin 3 R451C knockin mice - Cao_2022_Cell.Rep_41_111771 |
| Author(s) : Cao W , Li JH , Lin S , Xia QQ , Du YL , Yang Q , Ye YZ , Zeng LH , Li XY , Xu J , Luo JH |
| Ref : Cell Rep , 41 :111771 , 2022 |
| Abstract : |
| PubMedSearch : Cao_2022_Cell.Rep_41_111771 |
| PubMedID: 36476879 |
| Title : Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism - Wang_2022_Mol.Psychiatry__ |
| Author(s) : Wang L , Mirabella VR , Dai R , Su X , Xu R , Jadali A , Bernabucci M , Singh I , Chen Y , Tian J , Jiang P , Kwan KY , Pak C , Liu C , Comoletti D , Hart RP , Chen C , Sudhof TC , Pang ZP |
| Ref : Mol Psychiatry , : , 2022 |
| Abstract : |
| PubMedSearch : Wang_2022_Mol.Psychiatry__ |
| PubMedID: 36280753 |
| Title : The Emerging Role of the Gut-Brain-Microbiota Axis in Neurodevelopmental Disorders - Hosie_2022_Adv.Exp.Med.Biol_1383_141 |
| Author(s) : Hosie S , Abo-Shaban T , Lee CYQ , Matta SM , Shindler A , Gore R , Sharna SS , Herath M , Crack PJ , Franks AE , Hill-Yardin EL |
| Ref : Advances in Experimental Medicine & Biology , 1383 :141 , 2022 |
| Abstract : |
| PubMedSearch : Hosie_2022_Adv.Exp.Med.Biol_1383_141 |
| PubMedID: 36587154 |
| Gene_locus related to this paper: human-NLGN3 |
| Title : Mice with an autism-associated R451C mutation in neuroligin-3 show a cautious but accurate response style in touchscreen attention tasks - Burrows_2021_Genes.Brain.Behav__e12757 |
| Author(s) : Burrows EL , May C , Hill T , Churliov L , Johnson KA , Hannan AJ |
| Ref : Genes Brain Behav , :e12757 , 2021 |
| Abstract : |
| PubMedSearch : Burrows_2021_Genes.Brain.Behav__e12757 |
| PubMedID: 34085373 |
| Gene_locus related to this paper: human-NLGN3 |
| Title : An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum - Lai_2021_Front.Neural.Circuits_15_676891 |
| Author(s) : Lai ESK , Nakayama H , Miyazaki T , Nakazawa T , Tabuchi K , Hashimoto K , Watanabe M , Kano M |
| Ref : Front Neural Circuits , 15 :676891 , 2021 |
| Abstract : |
| PubMedSearch : Lai_2021_Front.Neural.Circuits_15_676891 |
| PubMedID: 34262438 |
| Gene_locus related to this paper: human-NLGN3 |
| Title : An altered glial phenotype in the NL3(R451C) mouse model of autism - Matta_2020_Sci.Rep_10_14492 |
| Author(s) : Matta SM , Moore Z , Walker FR , Hill-Yardin EL , Crack PJ |
| Ref : Sci Rep , 10 :14492 , 2020 |
| Abstract : |
| PubMedSearch : Matta_2020_Sci.Rep_10_14492 |
| PubMedID: 32879325 |
| Title : Altered Caecal Neuroimmune Interactions in the Neuroligin-3(R451C) Mouse Model of Autism - Sharna_2020_Front.Cell.Neurosci_14_85 |
| Author(s) : Sharna SS , Balasuriya GK , Hosie S , Nithianantharajah J , Franks AE , Hill-Yardin EL |
| Ref : Front Cell Neurosci , 14 :85 , 2020 |
| Abstract : |
| PubMedSearch : Sharna_2020_Front.Cell.Neurosci_14_85 |
| PubMedID: 32327975 |
| Gene_locus related to this paper: human-NLGN3 |
| Title : Environmental enrichment modulates affiliative and aggressive social behaviour in the neuroligin-3 R451C mouse model of autism spectrum disorder - Burrows_2020_Pharmacol.Biochem.Behav_195_172955 |
| Author(s) : Burrows EL , Koyama L , May C , Hill-Yardin EL , Hannan AJ |
| Ref : Pharmacol Biochem Behav , 195 :172955 , 2020 |
| Abstract : |
| PubMedSearch : Burrows_2020_Pharmacol.Biochem.Behav_195_172955 |
| PubMedID: 32474162 |
| Title : Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference - Norris_2019_Mol.Autism_10_42 |
| Author(s) : Norris RHC , Churilov L , Hannan AJ , Nithianantharajah J |
| Ref : Mol Autism , 10 :42 , 2019 |
| Abstract : |
| PubMedSearch : Norris_2019_Mol.Autism_10_42 |
| PubMedID: 31827744 |
| Gene_locus related to this paper: mouse-3neur , human-NLGN3 |
| Title : Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3 - Hosie_2019_Autism.Res_12_1043 |
| Author(s) : Hosie S , Ellis M , Swaminathan M , Ramalhosa F , Seger GO , Balasuriya GK , Gillberg C , Rastam M , Churilov L , McKeown SJ , Yalcinkaya N , Urvil P , Savidge T , Bell CA , Bodin O , Wood J , Franks AE , Bornstein JC , Hill-Yardin EL |
| Ref : Autism Res , 12 :1043 , 2019 |
| Abstract : |
| PubMedSearch : Hosie_2019_Autism.Res_12_1043 |
| PubMedID: 31119867 |
| Gene_locus related to this paper: mouse-3neur , human-NLGN3 |
| Title : Altered Amygdala Excitation and CB1 Receptor Modulation of Aggressive Behavior in the Neuroligin-3(R451C) Mouse Model of Autism - Hosie_2018_Front.Cell.Neurosci_12_234 |
| Author(s) : Hosie S , Malone DT , Liu S , Glass M , Adlard PA , Hannan AJ , Hill-Yardin EL |
| Ref : Front Cell Neurosci , 12 :234 , 2018 |
| Abstract : |
| PubMedSearch : Hosie_2018_Front.Cell.Neurosci_12_234 |
| PubMedID: 30123111 |
| Gene_locus related to this paper: mouse-3neur |
| Title : The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in the dorsal striatum - Martella_2018_Eur.J.Neurosci_47_701 |
| Author(s) : Martella G , Meringolo M , Trobiani L , De Jaco A , Pisani A , Bonsi P |
| Ref : European Journal of Neuroscience , 47 :701 , 2018 |
| Abstract : |
| PubMedSearch : Martella_2018_Eur.J.Neurosci_47_701 |
| PubMedID: 28921757 |
| Gene_locus related to this paper: mouse-3neur , human-NLGN3 |
| Title : Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice - Cao_2018_Neuron_97_1253 |
| Author(s) : Cao W , Lin S , Xia QQ , Du YL , Yang Q , Zhang MY , Lu YQ , Xu J , Duan SM , Xia J , Feng G , Luo JH |
| Ref : Neuron , 97 :1253 , 2018 |
| Abstract : |
| PubMedSearch : Cao_2018_Neuron_97_1253 |
| PubMedID: 29503190 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Social Isolation Alters Social and Mating Behavior in the R451C Neuroligin Mouse Model of Autism - Burrows_2017_Neural.Plast_2017_8361290 |
| Author(s) : Burrows EL , Eastwood AF , May C , Kolbe SC , Hill T , McLachlan NM , Churilov L , Hannan AJ |
| Ref : Neural Plast , 2017 :8361290 , 2017 |
| Abstract : |
| PubMedSearch : Burrows_2017_Neural.Plast_2017_8361290 |
| PubMedID: 28255463 |
| Gene_locus related to this paper: mouse-3neur |
| Title : A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice - Burrows_2015_Mol.Autism_6_62 |
| Author(s) : Burrows EL , Laskaris L , Koyama L , Churilov L , Bornstein JC , Hill-Yardin EL , Hannan AJ |
| Ref : Mol Autism , 6 :62 , 2015 |
| Abstract : |
| PubMedSearch : Burrows_2015_Mol.Autism_6_62 |
| PubMedID: 26583067 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism - Hill-Yardin_2015_Neurosci.Lett_589_57 |
| Author(s) : Hill-Yardin EL , Argyropoulos A , Hosie S , Rind G , Anderson P , Hannan AJ , O'Brien TJ |
| Ref : Neuroscience Letters , 589 :57 , 2015 |
| Abstract : |
| PubMedSearch : Hill-Yardin_2015_Neurosci.Lett_589_57 |
| PubMedID: 25592157 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Autism-related neuroligin-3 mutation alters social behavior and spatial learning - Jaramillo_2014_Autism.Res_7_264 |
| Author(s) : Jaramillo TC , Liu S , Pettersen A , Birnbaum SG , Powell CM |
| Ref : Autism Res , 7 :264 , 2014 |
| Abstract : |
| PubMedSearch : Jaramillo_2014_Autism.Res_7_264 |
| PubMedID: 24619977 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function - Etherton_2011_Proc.Natl.Acad.Sci.U.S.A_108_13764 |
| Author(s) : Etherton M , Foldy C , Sharma M , Tabuchi K , Liu X , Shamloo M , Malenka RC , Sudhof TC |
| Ref : Proc Natl Acad Sci U S A , 108 :13764 , 2011 |
| Abstract : |
| PubMedSearch : Etherton_2011_Proc.Natl.Acad.Sci.U.S.A_108_13764 |
| PubMedID: 21808020 |
| Gene_locus related to this paper: human-NLGN3 |
| Title : Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice - Chadman_2008_Autism.Res_1_147 |
| Author(s) : Chadman KK , Gong S , Scattoni ML , Boltuck SE , Gandhy SU , Heintz N , Crawley JN |
| Ref : Autism Res , 1 :147 , 2008 |
| Abstract : |
| PubMedSearch : Chadman_2008_Autism.Res_1_147 |
| PubMedID: 19360662 |
| Gene_locus related to this paper: mouse-3neur |
| Title : A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice - Tabuchi_2007_Science_318_71 |
| Author(s) : Tabuchi K , Blundell J , Etherton MR , Hammer RE , Liu X , Powell CM , Sudhof TC |
| Ref : Science , 318 :71 , 2007 |
| Abstract : |
| PubMedSearch : Tabuchi_2007_Science_318_71 |
| PubMedID: 17823315 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |