mouse-3neur

Mus musculus (Mouse) partial mRNA for neuroligin 3 protein

Comment

on chromosome X ENSMUSG00000031302 || Q8BYM5 from Okazaki some diff || Neuroligins constitute a family of proteins thought to mediate cell-to-cell interactions between neurons. Neuroligins function as ligands for the neurexin family of cell surface receptors. Homo sapiens KIAA1480 . More recently it was cloned by Philibert et al. with some aa differences and with two alternative forms HNL3 HNLS3S. ChrX q21.1. In 2 brothers with autism, one with typical autism and the other with Asperger syndrome, Jamain et al. (2003) identified a mutation R451C in the human-NLGN3 gene. arg451 in NLGN3, arg386 in BCHE, and arg395 in ACHE are conserved in mammalian species. In cellular transfection studies, De Jaco et al. (2006) inserted mutations homologous to the NLGN3 R451C mutation in BCHE and ACHE cDNAs and found that these mutations resulted in endoplasmic reticulum retention of the 2 proteins, similar to that observed with the NLGN3 R451C mutant protein. Tabuchi et al. (2007) introduced the R451C substitution in neuroligin-3 into mice. R451C mutant mice showed impaired social interactions but enhanced spatial learning abilities. Unexpectedly these behavioral changes were accompanied by an increase in inhibitory synaptic transmission with no apparent effect on excitatory synapses. Deletion of neuroligin-3, in contrast, did not cause such changes, indicating that the R451C substitution represents a gain-of-function mutation. Tabuchi et al. (2007) concluded that increased inhibitory synaptic transmission may contribute to human autism spectrum disorders and that the R451C knockin mice may be a useful model for studying autism-related behaviors. Recently Venkatesh et al. showed that neuronal activity promotes glioma growth through Neuroligin-3 secretion

Relationship

Family : Neuroligin

Block : C

Position in NCBI Life Tree : Mus musculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

No inhibitor

Sequence

Peptide

GSSQCGHEGA AYWADAVTPE SSSPASPPAR NMWLQPSLSL SPTPTVGRSL CLTLGFLSLV LRASTQAPAP TVNTHFGKLR GARVPLPSEI LGPVDQYLGV PYAAPPIGEK RFLPPEPPPS WSGIRNATHF PPVCPQNIHT AVPEVMLPVW FTANLDIVAT YIQEPNEDCL YLNVYVPTED VKRISKECAR KPNKKICRKG GSGAKKQGED LADNDGDEDE DIRDSGAKPV MVYIHGGSYM EGTGNMIDGS VLASYGNVIV ITLNYRVGVL GFLSTGDQAA KGNYGLLDQI QALRWVSENI AFFGGDPRRI TVFGSGIGAS CVSLLTLSHH SEGLFQRAII QSGSALSSWA VNYQPVKYTS LLADKVGCNV LDTVDMVDCL RQKSAKELVE QDIQPARYHV AFGPVIDGDV IPDDPEILME QGEFLNYDIM LGVNQGEGLK FVEGVVDPED GVSGTDFDYS VSNFVDNLYG YPEGKDTLRE TIKFMYTDWA DRDNPETRRK TLVALFTDHQ WVEPSVVTAD LHARYGSPTY FYAFYHHCQS LMKPAWSDAA HGDEVPYVFG VPMVGPTDLF PCNFSKNDVM LSAVVMTYWT NFAKTGDPNK PVPQDTKFIH TKANRFEEVA WSKYNPRDQL YLHIGLKPRV RDHYRATKVA FWKHLVPHLY NLHDMFHYTS TTTKVPPPDT THSSHITRRP NGKTWSTKRP AISPAYSNEN APGSWNGDQD AGPLLVENPR DYSTELSVTI AVGASLLFLN VLAFAALYYR KDKRRQEPLR QPSPQRGTGA PELGTAPEEE LAALQLGPTH HECEAGPPHD TLRLTALPDY TLTLRRSPDD IPLMTPNTIT MIPNSLVGLQ TLHPYNTFAA GFNSTGLPHS HSTTRV

References (20)

Title : Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in the Nlgn3(R451C) Mouse Model of Autism - Hosie_2024_Int.J.Mol.Sci_25_
Author(s) : Hosie S , Abo-Shaban T , Mou K , Balasuriya GK , Mohsenipour M , Alamoudi MU , Filippone RT , Belz GT , Franks AE , Bornstein JC , Nurgali K , Hill-Yardin EL
Ref : Int J Mol Sci , 25 : , 2024
PubMedID: 38255906
Gene_locus related to this paper: mouse-3neur

Title : Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation - Diamanti_2024_Traffic_25_e12930
Author(s) : Diamanti T , Trobiani L , Mautone L , Serafini F , Gioia R , Ferrucci L , Lauro C , Bianchi S , Perfetto C , Guglielmo S , Sollazzo R , Giorda E , Setini A , Ragozzino D , Miranda E , Comoletti D , Di Angelantonio S , Cacci E , De Jaco A
Ref : Traffic , 25 :e12930 , 2024
PubMedID: 38272450
Gene_locus related to this paper: human-NLGN3 , mouse-3neur

Title : Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task - Li_2024_Psychopharmacology.(Berl)__
Author(s) : Li S , May C , Pang TY , Churilov L , Hannan AJ , Johnson KA , Burrows EL
Ref : Psychopharmacology (Berl) , : , 2024
PubMedID: 38170320
Gene_locus related to this paper: human-NLGN3 , mouse-3neur

Title : Insulin-like growth factor 2 (IGF-2) rescues social deficits in NLG3(-\/y) mouse model of ASDs - Pizzarelli_2024_Front.Cell.Neurosci_17_1332179
Author(s) : Pizzarelli R , Pimpinella D , Jacobs C , Tartacca A , Kullolli U , Monyer H , Alberini CM , Griguoli M
Ref : Front Cell Neurosci , 17 :1332179 , 2024
PubMedID: 38298376
Gene_locus related to this paper: human-NLGN3 , mouse-3neur

Title : Impaired cecal motility and secretion alongside expansion of gut-associated lymphoid tissue in the Nlgn3(R451C) mouse model of autism - Lee_2023_Sci.Rep_13_12687
Author(s) : Lee CYQ , Balasuriya GK , Herath M , Franks AE , Hill-Yardin EL
Ref : Sci Rep , 13 :12687 , 2023
PubMedID: 37542090
Gene_locus related to this paper: mouse-3neur

Title : Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses - Altas_2023_Biol.Psychiatry__
Author(s) : Altas B , Tuffy LP , Patrizi A , Dimova K , Soykan T , Brandenburg C , Romanowski AJ , Whitten JR , Robertson CD , Khim SN , Crutcher GW , Ambrozkiewicz MC , Yagensky O , Krueger-Burg D , Hammer M , Hsiao HH , Laskowski PR , Dyck L , Puche AC , Sassoe-Pognetto M , Chua JJE , Urlaub H , Jahn O , Brose N , Poulopoulos A
Ref : Biological Psychiatryry , : , 2023
PubMedID: 38154503
Gene_locus related to this paper: human-NLGN3 , mouse-3neur

Title : Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice - Yoshida_2021_Nat.Commun_12_1848
Author(s) : Yoshida T , Yamagata A , Imai A , Kim J , Izumi H , Nakashima S , Shiroshima T , Maeda A , Iwasawa-Okamoto S , Azechi K , Osaka F , Saitoh T , Maenaka K , Shimada T , Fukata Y , Fukata M , Matsumoto J , Nishijo H , Takao K , Tanaka S , Okabe S , Tabuchi K , Uemura T , Mishina M , Mori H , Fukai S
Ref : Nat Commun , 12 :1848 , 2021
PubMedID: 33758193
Gene_locus related to this paper: mouse-3neur

Title : Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference - Norris_2019_Mol.Autism_10_42
Author(s) : Norris RHC , Churilov L , Hannan AJ , Nithianantharajah J
Ref : Mol Autism , 10 :42 , 2019
PubMedID: 31827744
Gene_locus related to this paper: mouse-3neur , human-NLGN3

Title : Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3 - Hosie_2019_Autism.Res_12_1043
Author(s) : Hosie S , Ellis M , Swaminathan M , Ramalhosa F , Seger GO , Balasuriya GK , Gillberg C , Rastam M , Churilov L , McKeown SJ , Yalcinkaya N , Urvil P , Savidge T , Bell CA , Bodin O , Wood J , Franks AE , Bornstein JC , Hill-Yardin EL
Ref : Autism Res , 12 :1043 , 2019
PubMedID: 31119867
Gene_locus related to this paper: mouse-3neur , human-NLGN3

Title : Genetic background effects in Neuroligin-3 mutant mice: Minimal behavioral abnormalities on C57 background - Jaramillo_2018_Autism.Res_11_234
Author(s) : Jaramillo TC , Escamilla CO , Liu S , Peca L , Birnbaum SG , Powell CM
Ref : Autism Res , 11 :234 , 2018
PubMedID: 29028156
Gene_locus related to this paper: mouse-3neur

Title : Altered Amygdala Excitation and CB1 Receptor Modulation of Aggressive Behavior in the Neuroligin-3(R451C) Mouse Model of Autism - Hosie_2018_Front.Cell.Neurosci_12_234
Author(s) : Hosie S , Malone DT , Liu S , Glass M , Adlard PA , Hannan AJ , Hill-Yardin EL
Ref : Front Cell Neurosci , 12 :234 , 2018
PubMedID: 30123111
Gene_locus related to this paper: mouse-3neur

Title : The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in the dorsal striatum - Martella_2018_Eur.J.Neurosci_47_701
Author(s) : Martella G , Meringolo M , Trobiani L , De Jaco A , Pisani A , Bonsi P
Ref : European Journal of Neuroscience , 47 :701 , 2018
PubMedID: 28921757
Gene_locus related to this paper: mouse-3neur , human-NLGN3

Title : Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice - Cao_2018_Neuron_97_1253
Author(s) : Cao W , Lin S , Xia QQ , Du YL , Yang Q , Zhang MY , Lu YQ , Xu J , Duan SM , Xia J , Feng G , Luo JH
Ref : Neuron , 97 :1253 , 2018
PubMedID: 29503190
Gene_locus related to this paper: mouse-3neur

Title : Social Isolation Alters Social and Mating Behavior in the R451C Neuroligin Mouse Model of Autism - Burrows_2017_Neural.Plast_2017_8361290
Author(s) : Burrows EL , Eastwood AF , May C , Kolbe SC , Hill T , McLachlan NM , Churilov L , Hannan AJ
Ref : Neural Plast , 2017 :8361290 , 2017
PubMedID: 28255463
Gene_locus related to this paper: mouse-3neur

Title : A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice - Burrows_2015_Mol.Autism_6_62
Author(s) : Burrows EL , Laskaris L , Koyama L , Churilov L , Bornstein JC , Hill-Yardin EL , Hannan AJ
Ref : Mol Autism , 6 :62 , 2015
PubMedID: 26583067
Gene_locus related to this paper: mouse-3neur

Title : Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism - Hill-Yardin_2015_Neurosci.Lett_589_57
Author(s) : Hill-Yardin EL , Argyropoulos A , Hosie S , Rind G , Anderson P , Hannan AJ , O'Brien TJ
Ref : Neuroscience Letters , 589 :57 , 2015
PubMedID: 25592157
Gene_locus related to this paper: mouse-3neur

Title : Autism-related neuroligin-3 mutation alters social behavior and spatial learning - Jaramillo_2014_Autism.Res_7_264
Author(s) : Jaramillo TC , Liu S , Pettersen A , Birnbaum SG , Powell CM
Ref : Autism Res , 7 :264 , 2014
PubMedID: 24619977
Gene_locus related to this paper: mouse-3neur

Title : Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice - Chadman_2008_Autism.Res_1_147
Author(s) : Chadman KK , Gong S , Scattoni ML , Boltuck SE , Gandhy SU , Heintz N , Crawley JN
Ref : Autism Res , 1 :147 , 2008
PubMedID: 19360662
Gene_locus related to this paper: mouse-3neur

Title : Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs - Okazaki_2002_Nature_420_563
Author(s) : Okazaki Y , Furuno M , Kasukawa T , Adachi J , Bono H , Kondo S , Nikaido I , Osato N , Saito R , Suzuki H , Yamanaka I , Kiyosawa H , Yagi K , Tomaru Y , Hasegawa Y , Nogami A , Schonbach C , Gojobori T , Baldarelli R , Hill DP , Bult C , Hume DA , Quackenbush J , Schriml LM , Kanapin A , Matsuda H , Batalov S , Beisel KW , Blake JA , Bradt D , Brusic V , Chothia C , Corbani LE , Cousins S , Dalla E , Dragani TA , Fletcher CF , Forrest A , Frazer KS , Gaasterland T , Gariboldi M , Gissi C , Godzik A , Gough J , Grimmond S , Gustincich S , Hirokawa N , Jackson IJ , Jarvis ED , Kanai A , Kawaji H , Kawasawa Y , Kedzierski RM , King BL , Konagaya A , Kurochkin IV , Lee Y , Lenhard B , Lyons PA , Maglott DR , Maltais L , Marchionni L , McKenzie L , Miki H , Nagashima T , Numata K , Okido T , Pavan WJ , Pertea G , Pesole G , Petrovsky N , Pillai R , Pontius JU , Qi D , Ramachandran S , Ravasi T , Reed JC , Reed DJ , Reid J , Ring BZ , Ringwald M , Sandelin A , Schneider C , Semple CA , Setou M , Shimada K , Sultana R , Takenaka Y , Taylor MS , Teasdale RD , Tomita M , Verardo R , Wagner L , Wahlestedt C , Wang Y , Watanabe Y , Wells C , Wilming LG , Wynshaw-Boris A , Yanagisawa M , Yang I , Yang L , Yuan Z , Zavolan M , Zhu Y , Zimmer A , Carninci P , Hayatsu N , Hirozane-Kishikawa T , Konno H , Nakamura M , Sakazume N , Sato K , Shiraki T , Waki K , Kawai J , Aizawa K , Arakawa T , Fukuda S , Hara A , Hashizume W , Imotani K , Ishii Y , Itoh M , Kagawa I , Miyazaki A , Sakai K , Sasaki D , Shibata K , Shinagawa A , Yasunishi A , Yoshino M , Waterston R , Lander ES , Rogers J , Birney E , Hayashizaki Y
Ref : Nature , 420 :563 , 2002
PubMedID: 12466851
Gene_locus related to this paper: mouse-1lipg , mouse-1llip , mouse-1plrp , mouse-3neur , mouse-ABH15 , mouse-abhd4 , mouse-abhd5 , mouse-Abhd8 , mouse-Abhd11 , mouse-abhda , mouse-acot4 , mouse-adcl4 , mouse-AI607300 , mouse-BAAT , mouse-bphl , mouse-C87498 , mouse-Ldah , mouse-Ces1d , mouse-Ces2e , mouse-CMBL , mouse-DGLB , mouse-dpp9 , mouse-ES10 , mouse-F135A , mouse-FASN , mouse-hslip , mouse-hyes , mouse-Kansl3 , mouse-LIPH , mouse-LIPK , mouse-lipli , mouse-LIPM , mouse-lypla1 , mouse-lypla2 , mouse-MEST , mouse-MGLL , mouse-ndr4 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-ppce , mouse-Ppgb , mouse-PPME1 , mouse-q3uuq7 , mouse-Q8BLF1 , mouse-ACOT6 , mouse-Q8C1A9 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-Q8BGG9 , mouse-Q8C167 , mouse-rbbp9 , mouse-SERHL , mouse-tssp

Title : Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia - Gilbert_2001_Glia_34_151
Author(s) : Gilbert M , Smith J , Roskams AJ , Auld VJ
Ref : Glia , 34 :151 , 2001
PubMedID: 11329178
Gene_locus related to this paper: mouse-3neur , ratno-1neur , ratno-2neur , ratno-3neur