mouse-3neur
Mus musculus (Mouse) partial mRNA for neuroligin 3 protein
Comment
on chromosome X ENSMUSG00000031302 || Q8BYM5 from Okazaki some diff || Neuroligins constitute a family of proteins thought to mediate cell-to-cell interactions between neurons. Neuroligins function as ligands for the neurexin family of cell surface receptors. Homo sapiens KIAA1480 . More recently it was cloned by Philibert et al. with some aa differences and with two alternative forms HNL3 HNLS3S. ChrX q21.1. In 2 brothers with autism, one with typical autism and the other with Asperger syndrome, Jamain et al. (2003) identified a mutation R451C in the human-NLGN3 gene. arg451 in NLGN3, arg386 in BCHE, and arg395 in ACHE are conserved in mammalian species. In cellular transfection studies, De Jaco et al. (2006) inserted mutations homologous to the NLGN3 R451C mutation in BCHE and ACHE cDNAs and found that these mutations resulted in endoplasmic reticulum retention of the 2 proteins, similar to that observed with the NLGN3 R451C mutant protein. Tabuchi et al. (2007) introduced the R451C substitution in neuroligin-3 into mice. R451C mutant mice showed impaired social interactions but enhanced spatial learning abilities. Unexpectedly these behavioral changes were accompanied by an increase in inhibitory synaptic transmission with no apparent effect on excitatory synapses. Deletion of neuroligin-3, in contrast, did not cause such changes, indicating that the R451C substitution represents a gain-of-function mutation. Tabuchi et al. (2007) concluded that increased inhibitory synaptic transmission may contribute to human autism spectrum disorders and that the R451C knockin mice may be a useful model for studying autism-related behaviors. Recently Venkatesh et al. showed that neuronal activity promotes glioma growth through Neuroligin-3 secretion
Relationship
Family : Neuroligin
Block : C
Position in NCBI Life Tree : Mus musculus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N EMolecular evidence
Database
Sequence
Peptide
GSSQCGHEGA AYWADAVTPE SSSPASPPAR NMWLQPSLSL SPTPTVGRSL CLTLGFLSLV LRASTQAPAP TVNTHFGKLR GARVPLPSEI LGPVDQYLGV PYAAPPIGEK RFLPPEPPPS WSGIRNATHF PPVCPQNIHT AVPEVMLPVW FTANLDIVAT YIQEPNEDCL YLNVYVPTED VKRISKECAR KPNKKICRKG GSGAKKQGED LADNDGDEDE DIRDSGAKPV MVYIHGGSYM EGTGNMIDGS VLASYGNVIV ITLNYRVGVL GFLSTGDQAA KGNYGLLDQI QALRWVSENI AFFGGDPRRI TVFGSGIGAS CVSLLTLSHH SEGLFQRAII QSGSALSSWA VNYQPVKYTS LLADKVGCNV LDTVDMVDCL RQKSAKELVE QDIQPARYHV AFGPVIDGDV IPDDPEILME QGEFLNYDIM LGVNQGEGLK FVEGVVDPED GVSGTDFDYS VSNFVDNLYG YPEGKDTLRE TIKFMYTDWA DRDNPETRRK TLVALFTDHQ WVEPSVVTAD LHARYGSPTY FYAFYHHCQS LMKPAWSDAA HGDEVPYVFG VPMVGPTDLF PCNFSKNDVM LSAVVMTYWT NFAKTGDPNK PVPQDTKFIH TKANRFEEVA WSKYNPRDQL YLHIGLKPRV RDHYRATKVA FWKHLVPHLY NLHDMFHYTS TTTKVPPPDT THSSHITRRP NGKTWSTKRP AISPAYSNEN APGSWNGDQD AGPLLVENPR DYSTELSVTI AVGASLLFLN VLAFAALYYR KDKRRQEPLR QPSPQRGTGA PELGTAPEEE LAALQLGPTH HECEAGPPHD TLRLTALPDY TLTLRRSPDD IPLMTPNTIT MIPNSLVGLQ TLHPYNTFAA GFNSTGLPHS HSTTRV
References (23)
| Title : Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in the Nlgn3(R451C) Mouse Model of Autism - Hosie_2024_Int.J.Mol.Sci_25_ |
| Author(s) : Hosie S , Abo-Shaban T , Mou K , Balasuriya GK , Mohsenipour M , Alamoudi MU , Filippone RT , Belz GT , Franks AE , Bornstein JC , Nurgali K , Hill-Yardin EL |
| Ref : Int J Mol Sci , 25 : , 2024 |
| Abstract : |
| PubMedSearch : Hosie_2024_Int.J.Mol.Sci_25_ |
| PubMedID: 38255906 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation - Diamanti_2024_Traffic_25_e12930 |
| Author(s) : Diamanti T , Trobiani L , Mautone L , Serafini F , Gioia R , Ferrucci L , Lauro C , Bianchi S , Perfetto C , Guglielmo S , Sollazzo R , Giorda E , Setini A , Ragozzino D , Miranda E , Comoletti D , Di Angelantonio S , Cacci E , De Jaco A |
| Ref : Traffic , 25 :e12930 , 2024 |
| Abstract : |
| PubMedSearch : Diamanti_2024_Traffic_25_e12930 |
| PubMedID: 38272450 |
| Gene_locus related to this paper: human-NLGN3 , mouse-3neur |
| Title : Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task - Li_2024_Psychopharmacology.(Berl)__ |
| Author(s) : Li S , May C , Pang TY , Churilov L , Hannan AJ , Johnson KA , Burrows EL |
| Ref : Psychopharmacology (Berl) , : , 2024 |
| Abstract : |
| PubMedSearch : Li_2024_Psychopharmacology.(Berl)__ |
| PubMedID: 38170320 |
| Gene_locus related to this paper: human-NLGN3 , mouse-3neur |
| Title : Sex Differences in Morphine Sensitivity of Neuroligin-3 Knockout Mice - Brandner_2024_bioRxiv__ |
| Author(s) : Brandner DD , Mashal MA , Grissom NM , Rothwell PE |
| Ref : Biorxiv , : , 2024 |
| Abstract : |
| PubMedSearch : Brandner_2024_bioRxiv__ |
| PubMedID: 38854153 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Weaker neuroligin 2 - neurexin 1beta interaction tethers membranes and signal synaptogenesis through clustering - Boyd_2024_bioRxiv__ |
| Author(s) : Boyd R , Jaqaman K , Wang W |
| Ref : Biorxiv , : , 2024 |
| Abstract : |
| PubMedSearch : Boyd_2024_bioRxiv__ |
| PubMedID: 39464163 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Insulin-like growth factor 2 (IGF-2) rescues social deficits in NLG3(-\/y) mouse model of ASDs - Pizzarelli_2024_Front.Cell.Neurosci_17_1332179 |
| Author(s) : Pizzarelli R , Pimpinella D , Jacobs C , Tartacca A , Kullolli U , Monyer H , Alberini CM , Griguoli M |
| Ref : Front Cell Neurosci , 17 :1332179 , 2024 |
| Abstract : |
| PubMedSearch : Pizzarelli_2024_Front.Cell.Neurosci_17_1332179 |
| PubMedID: 38298376 |
| Gene_locus related to this paper: human-NLGN3 , mouse-3neur |
| Title : Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses - Altas_2023_Biol.Psychiatry__ |
| Author(s) : Altas B , Tuffy LP , Patrizi A , Dimova K , Soykan T , Brandenburg C , Romanowski AJ , Whitten JR , Robertson CD , Khim SN , Crutcher GW , Ambrozkiewicz MC , Yagensky O , Krueger-Burg D , Hammer M , Hsiao HH , Laskowski PR , Dyck L , Puche AC , Sassoe-Pognetto M , Chua JJE , Urlaub H , Jahn O , Brose N , Poulopoulos A |
| Ref : Biological Psychiatryry , : , 2023 |
| Abstract : |
| PubMedSearch : Altas_2023_Biol.Psychiatry__ |
| PubMedID: 38154503 |
| Gene_locus related to this paper: human-NLGN3 , mouse-3neur |
| Title : Impaired cecal motility and secretion alongside expansion of gut-associated lymphoid tissue in the Nlgn3(R451C) mouse model of autism - Lee_2023_Sci.Rep_13_12687 |
| Author(s) : Lee CYQ , Balasuriya GK , Herath M , Franks AE , Hill-Yardin EL |
| Ref : Sci Rep , 13 :12687 , 2023 |
| Abstract : |
| PubMedSearch : Lee_2023_Sci.Rep_13_12687 |
| PubMedID: 37542090 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice - Yoshida_2021_Nat.Commun_12_1848 |
| Author(s) : Yoshida T , Yamagata A , Imai A , Kim J , Izumi H , Nakashima S , Shiroshima T , Maeda A , Iwasawa-Okamoto S , Azechi K , Osaka F , Saitoh T , Maenaka K , Shimada T , Fukata Y , Fukata M , Matsumoto J , Nishijo H , Takao K , Tanaka S , Okabe S , Tabuchi K , Uemura T , Mishina M , Mori H , Fukai S |
| Ref : Nat Commun , 12 :1848 , 2021 |
| Abstract : |
| PubMedSearch : Yoshida_2021_Nat.Commun_12_1848 |
| PubMedID: 33758193 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference - Norris_2019_Mol.Autism_10_42 |
| Author(s) : Norris RHC , Churilov L , Hannan AJ , Nithianantharajah J |
| Ref : Mol Autism , 10 :42 , 2019 |
| Abstract : |
| PubMedSearch : Norris_2019_Mol.Autism_10_42 |
| PubMedID: 31827744 |
| Gene_locus related to this paper: mouse-3neur , human-NLGN3 |
| Title : Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3 - Hosie_2019_Autism.Res_12_1043 |
| Author(s) : Hosie S , Ellis M , Swaminathan M , Ramalhosa F , Seger GO , Balasuriya GK , Gillberg C , Rastam M , Churilov L , McKeown SJ , Yalcinkaya N , Urvil P , Savidge T , Bell CA , Bodin O , Wood J , Franks AE , Bornstein JC , Hill-Yardin EL |
| Ref : Autism Res , 12 :1043 , 2019 |
| Abstract : |
| PubMedSearch : Hosie_2019_Autism.Res_12_1043 |
| PubMedID: 31119867 |
| Gene_locus related to this paper: mouse-3neur , human-NLGN3 |
| Title : Genetic background effects in Neuroligin-3 mutant mice: Minimal behavioral abnormalities on C57 background - Jaramillo_2018_Autism.Res_11_234 |
| Author(s) : Jaramillo TC , Escamilla CO , Liu S , Peca L , Birnbaum SG , Powell CM |
| Ref : Autism Res , 11 :234 , 2018 |
| Abstract : |
| PubMedSearch : Jaramillo_2018_Autism.Res_11_234 |
| PubMedID: 29028156 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Altered Amygdala Excitation and CB1 Receptor Modulation of Aggressive Behavior in the Neuroligin-3(R451C) Mouse Model of Autism - Hosie_2018_Front.Cell.Neurosci_12_234 |
| Author(s) : Hosie S , Malone DT , Liu S , Glass M , Adlard PA , Hannan AJ , Hill-Yardin EL |
| Ref : Front Cell Neurosci , 12 :234 , 2018 |
| Abstract : |
| PubMedSearch : Hosie_2018_Front.Cell.Neurosci_12_234 |
| PubMedID: 30123111 |
| Gene_locus related to this paper: mouse-3neur |
| Title : The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in the dorsal striatum - Martella_2018_Eur.J.Neurosci_47_701 |
| Author(s) : Martella G , Meringolo M , Trobiani L , De Jaco A , Pisani A , Bonsi P |
| Ref : European Journal of Neuroscience , 47 :701 , 2018 |
| Abstract : |
| PubMedSearch : Martella_2018_Eur.J.Neurosci_47_701 |
| PubMedID: 28921757 |
| Gene_locus related to this paper: mouse-3neur , human-NLGN3 |
| Title : Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice - Cao_2018_Neuron_97_1253 |
| Author(s) : Cao W , Lin S , Xia QQ , Du YL , Yang Q , Zhang MY , Lu YQ , Xu J , Duan SM , Xia J , Feng G , Luo JH |
| Ref : Neuron , 97 :1253 , 2018 |
| Abstract : |
| PubMedSearch : Cao_2018_Neuron_97_1253 |
| PubMedID: 29503190 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Social Isolation Alters Social and Mating Behavior in the R451C Neuroligin Mouse Model of Autism - Burrows_2017_Neural.Plast_2017_8361290 |
| Author(s) : Burrows EL , Eastwood AF , May C , Kolbe SC , Hill T , McLachlan NM , Churilov L , Hannan AJ |
| Ref : Neural Plast , 2017 :8361290 , 2017 |
| Abstract : |
| PubMedSearch : Burrows_2017_Neural.Plast_2017_8361290 |
| PubMedID: 28255463 |
| Gene_locus related to this paper: mouse-3neur |
| Title : A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice - Burrows_2015_Mol.Autism_6_62 |
| Author(s) : Burrows EL , Laskaris L , Koyama L , Churilov L , Bornstein JC , Hill-Yardin EL , Hannan AJ |
| Ref : Mol Autism , 6 :62 , 2015 |
| Abstract : |
| PubMedSearch : Burrows_2015_Mol.Autism_6_62 |
| PubMedID: 26583067 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism - Hill-Yardin_2015_Neurosci.Lett_589_57 |
| Author(s) : Hill-Yardin EL , Argyropoulos A , Hosie S , Rind G , Anderson P , Hannan AJ , O'Brien TJ |
| Ref : Neuroscience Letters , 589 :57 , 2015 |
| Abstract : |
| PubMedSearch : Hill-Yardin_2015_Neurosci.Lett_589_57 |
| PubMedID: 25592157 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Autism-related neuroligin-3 mutation alters social behavior and spatial learning - Jaramillo_2014_Autism.Res_7_264 |
| Author(s) : Jaramillo TC , Liu S , Pettersen A , Birnbaum SG , Powell CM |
| Ref : Autism Res , 7 :264 , 2014 |
| Abstract : |
| PubMedSearch : Jaramillo_2014_Autism.Res_7_264 |
| PubMedID: 24619977 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors - Rothwell_2014_Cell_158_198 |
| Author(s) : Rothwell PE , Fuccillo MV , Maxeiner S , Hayton SJ , Gokce O , Lim BK , Fowler SC , Malenka RC , Sudhof TC |
| Ref : Cell , 158 :198 , 2014 |
| Abstract : |
| PubMedSearch : Rothwell_2014_Cell_158_198 |
| PubMedID: 24995986 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice - Chadman_2008_Autism.Res_1_147 |
| Author(s) : Chadman KK , Gong S , Scattoni ML , Boltuck SE , Gandhy SU , Heintz N , Crawley JN |
| Ref : Autism Res , 1 :147 , 2008 |
| Abstract : |
| PubMedSearch : Chadman_2008_Autism.Res_1_147 |
| PubMedID: 19360662 |
| Gene_locus related to this paper: mouse-3neur |
| Title : Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia - Gilbert_2001_Glia_34_151 |
| Author(s) : Gilbert M , Smith J , Roskams AJ , Auld VJ |
| Ref : Glia , 34 :151 , 2001 |
| Abstract : |
| PubMedSearch : Gilbert_2001_Glia_34_151 |
| PubMedID: 11329178 |
| Gene_locus related to this paper: mouse-3neur , ratno-1neur , ratno-2neur , ratno-3neur |