MINA
General
Type : Oxime, Uncharged Oxime
Chemical_Nomenclature : (1E)-1-hydroxyiminopropan-2-one
Canonical SMILES : CC(=O)C=NO
InChI : InChI=1S\/C3H5NO2\/c1-3(5)2-4-6\/h2,6H,1H3\/b4-2+
InChIKey : OVGLVOLWBBGQHS-DUXPYHPUSA-N
Other name(s) : Isonitrosoacetone || Anti-Pyruvic aldehyde 1-oxime || Monoisonitrosoacetone || 3-Hydroxyiminoacetone || Pyruvaldehyde 1-oxime || 2-Oxopropanal-1-oxime || 1-[5-(2,4-dichlorophenoxy)pentyl]-1H-imidazole
Target
Structure : No structure
Families : No family
References (9)
| Title : The tertiary oxime monoisonitrosoacetone penetrates the brain, reactivates inhibited acetylcholinesterase, and reduces mortality and morbidity following lethal sarin intoxication in guinea pigs - Shih_2021_Toxicol.Appl.Pharmacol__115443 |
| Author(s) : Shih TM , Oyler BL , Capacio BR , Koplovitz I |
| Ref : Toxicol Appl Pharmacol , :115443 , 2021 |
| Abstract : |
| PubMedSearch : Shih_2021_Toxicol.Appl.Pharmacol__115443 |
| PubMedID: 33548273 |
| Title : Centrally acting oximes in reactivation of tabun-phosphoramidated AChE - Kovarik_2013_Chem.Biol.Interact_203_77 |
| Author(s) : Kovarik Z , Macek Hrvat N , Sit RK , Radic Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 203 :77 , 2013 |
| Abstract : |
| PubMedSearch : Kovarik_2013_Chem.Biol.Interact_203_77 |
| PubMedID: 22960624 |
| Title : Amidine-oximes: reactivators for organophosphate exposure - Kalisiak_2011_J.Med.Chem_54_3319 |
| Author(s) : Kalisiak J , Ralph EC , Zhang J , Cashman JR |
| Ref : Journal of Medicinal Chemistry , 54 :3319 , 2011 |
| Abstract : |
| PubMedSearch : Kalisiak_2011_J.Med.Chem_54_3319 |
| PubMedID: 21438612 |
| Title : New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases - Sit_2011_J.Biol.Chem_286_19422 |
| Author(s) : Sit RK , Radic Z , Gerardi V , Zhang L , Garcia E , Katalinic M , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Journal of Biological Chemistry , 286 :19422 , 2011 |
| Abstract : |
| PubMedSearch : Sit_2011_J.Biol.Chem_286_19422 |
| PubMedID: 21464125 |
| Title : Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication - Shih_2010_J.Mol.Neurosci_40_63 |
| Author(s) : Shih TM , Skovira JW , O'Donnell JC , McDonough JH |
| Ref : Journal of Molecular Neuroscience , 40 :63 , 2010 |
| Abstract : |
| PubMedSearch : Shih_2010_J.Mol.Neurosci_40_63 |
| PubMedID: 19680820 |
| Title : Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs - Skovira_2010_Chem.Biol.Interact_187_318 |
| Author(s) : Skovira JW , O'Donnell JC , Koplovitz I , Kan RK , McDonough JH , Shih TM |
| Ref : Chemico-Biological Interactions , 187 :318 , 2010 |
| Abstract : |
| PubMedSearch : Skovira_2010_Chem.Biol.Interact_187_318 |
| PubMedID: 20230808 |
| Title : Neutralization of the action of diisopropyl-fluorophosphate by an oxime (mono-isonitrosoacetone) - |
| Author(s) : Harris G , McCulloch C |
| Ref : American Journal of Ophthalmology , 50 :414 , 1960 |
| PubMedID: 14399946 |
| Title : The effect of some oximes in sarin poisoning - Rutland_1958_Br.J.Pharmacol.Chemother_13_399 |
| Author(s) : Rutland JP |
| Ref : British Journal of Pharmacology and Chemotherapy , 13 :399 , 1958 |
| Abstract : |
| PubMedSearch : Rutland_1958_Br.J.Pharmacol.Chemother_13_399 |
| PubMedID: 13618543 |
| Title : Oximes and atropine in sarin poisoning - Askew_1957_Br.J.Pharmacol.Chemother_12_340 |
| Author(s) : Askew BM |
| Ref : British Journal of Pharmacology and Chemotherapy , 12 :340 , 1957 |
| Abstract : |
| PubMedSearch : Askew_1957_Br.J.Pharmacol.Chemother_12_340 |
| PubMedID: 13460241 |