Full name : Sharpless K. Barry
First name : K. Barry
Mail : Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037-1000
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Country : USA
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| Title : Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical - Taylor_2021_J.Neurochem__ |
| Author(s) : Taylor P , Shong YJ , Samskey N , Ho KY , Radic Z , Fenical W , Sharpless KB , Kovarik Z , Andrea Camacho-Hernandez G |
| Ref : Journal of Neurochemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Taylor_2021_J.Neurochem__ |
| PubMedID: 33638151 |
| Title : Enhancing target tissue levels and diminishing plasma clearance of ionizing zwitterionic antidotes in organophosphate exposures - Shyong_2021_J.Pharmacol.Exp.Ther__ |
| Author(s) : Shyong YJ , Sepulveda Y , Garcia A , Samskey NM , Radic Z , Sit R , Sharpless KB , Momper JD , Taylor P |
| Ref : Journal of Pharmacology & Experimental Therapeutics , : , 2021 |
| Abstract : |
| PubMedSearch : Shyong_2021_J.Pharmacol.Exp.Ther__ |
| PubMedID: 34145064 |
| Title : Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases - Macek Hrvat_2019_Toxicol.Lett_321_83 |
| Author(s) : Macek Hrvat N , Kalisiak J , Sinko G , Radic Z , Sharpless KB , Taylor P , Kovarik Z |
| Ref : Toxicol Lett , 321 :83 , 2019 |
| Abstract : |
| PubMedSearch : Macek Hrvat_2019_Toxicol.Lett_321_83 |
| PubMedID: 31863869 |
| Title : Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure - Taylor_2019_Chem.Biol.Interact_13ChEPon_308_194 |
| Author(s) : Taylor P , Yan-Jye S , Momper J , Hou W , Camacho-Hernandez GA , Radic Z , Rosenberg YJ , Kovarik Z , Sit R , Sharpless KB |
| Ref : Chemico-Biological Interactions , 308 :194 , 2019 |
| Abstract : |
| PubMedSearch : Taylor_2019_Chem.Biol.Interact_13ChEPon_308_194 |
| PubMedID: 31100277 |
| Title : Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase - Kovarik_2019_Toxicol.Appl.Pharmacol_372_40 |
| Author(s) : Kovarik Z , Macek Hrvat N , Kalisiak J , Katalinic M , Sit RK , Zorbaz T , Radic Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Toxicol Appl Pharmacol , 372 :40 , 2019 |
| Abstract : |
| PubMedSearch : Kovarik_2019_Toxicol.Appl.Pharmacol_372_40 |
| PubMedID: 30978400 |
| Gene_locus related to this paper: human-ACHE |
| Title : Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase - Kovarik_2019_Chemistry_25_4100 |
| Author(s) : Kovarik Z , Kalisiak J , Macek Hrvat N , Katalinic M , Zorbaz T , Zunec S , Green C , Radic Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemistry , 25 :4100 , 2019 |
| Abstract : |
| PubMedSearch : Kovarik_2019_Chemistry_25_4100 |
| PubMedID: 30458057 |
| Title : Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure - Sit_2018_J.Pharmacol.Exp.Ther_367_363 |
| Author(s) : Sit RK , Kovarik Z , Macek Hrvat N , Zunec S , Green C , Fokin VV , Sharpless KB , Radic Z , Taylor P |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 367 :363 , 2018 |
| Abstract : |
| PubMedSearch : Sit_2018_J.Pharmacol.Exp.Ther_367_363 |
| PubMedID: 30190337 |
| Title : Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase - Bourne_2016_J.Am.Chem.Soc_138_1611 |
| Author(s) : Bourne Y , Sharpless KB , Taylor P , Marchot P |
| Ref : Journal of the American Chemical Society , 138 :1611 , 2016 |
| Abstract : |
| PubMedSearch : Bourne_2016_J.Am.Chem.Soc_138_1611 |
| PubMedID: 26731630 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification - Sit_2014_J.Med.Chem_57_1378 |
| Author(s) : Sit RK , Fokin VV , Amitai G , Sharpless KB , Taylor P , Radic Z |
| Ref : Journal of Medicinal Chemistry , 57 :1378 , 2014 |
| Abstract : |
| PubMedSearch : Sit_2014_J.Med.Chem_57_1378 |
| PubMedID: 24571195 |
| Title : Centrally acting oximes in reactivation of tabun-phosphoramidated AChE - Kovarik_2013_Chem.Biol.Interact_203_77 |
| Author(s) : Kovarik Z , Macek Hrvat N , Sit RK , Radic Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 203 :77 , 2013 |
| Abstract : |
| PubMedSearch : Kovarik_2013_Chem.Biol.Interact_203_77 |
| PubMedID: 22960624 |
| Title : Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates - Radic_2013_Chem.Biol.Interact_203_67 |
| Author(s) : Radic Z , Sit RK , Garcia E , Zhang LM , Zunec S , Kovarik Z , Amitai G , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 203 :67 , 2013 |
| Abstract : |
| PubMedSearch : Radic_2013_Chem.Biol.Interact_203_67 |
| PubMedID: 22975155 |
| Title : Automated docking with protein flexibility in the design of femtomolar click chemistry inhibitors of acetylcholinesterase - Morris_2013_J.Chem.Inf.Model_53_898 |
| Author(s) : Morris GM , Green LG , Radic Z , Taylor P , Sharpless KB , Olson AJ , Grynszpan F |
| Ref : J Chem Inf Model , 53 :898 , 2013 |
| Abstract : |
| PubMedSearch : Morris_2013_J.Chem.Inf.Model_53_898 |
| PubMedID: 23451944 |
| Title : Synthesis of selective agonists for the alpha7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates - Yamauchi_2012_Mol.Pharmacol_82_687 |
| Author(s) : Yamauchi JG , Gomez K , Grimster N , Dufouil M , Nemecz A , Fotsing JR , Ho KY , Talley TT , Sharpless KB , Fokin VV , Taylor P |
| Ref : Molecular Pharmacology , 82 :687 , 2012 |
| Abstract : |
| PubMedSearch : Yamauchi_2012_Mol.Pharmacol_82_687 |
| PubMedID: 22784805 |
| Title : Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases - Radic_2012_J.Biol.Chem_287_11798 |
| Author(s) : Radic Z , Sit RK , Kovarik Z , Zunec S , Garcia E , Zhang L , Amitai G , Green C , Radic B , Fokin VV , Sharpless KB , Taylor P |
| Ref : Journal of Biological Chemistry , 287 :11798 , 2012 |
| Abstract : |
| PubMedSearch : Radic_2012_J.Biol.Chem_287_11798 |
| PubMedID: 22343626 |
| Title : Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template - Grimster_2012_J.Am.Chem.Soc_134_6732 |
| Author(s) : Grimster NP , Stump B , Fotsing JR , Weide T , Talley TT , Yamauchi JG , Nemecz A , Kim C , Ho KY , Sharpless KB , Taylor P , Fokin VV |
| Ref : Journal of the American Chemical Society , 134 :6732 , 2012 |
| Abstract : |
| PubMedSearch : Grimster_2012_J.Am.Chem.Soc_134_6732 |
| PubMedID: 22394239 |
| Title : Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging - Cochran_2011_J.Biol.Chem_286_29718 |
| Author(s) : Cochran R , Kalisiak J , Tuylu Kucukkilinc T , Radic Z , Garcia E , Zhang L , Ho KY , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Journal of Biological Chemistry , 286 :29718 , 2011 |
| Abstract : |
| PubMedSearch : Cochran_2011_J.Biol.Chem_286_29718 |
| PubMedID: 21730071 |
| Title : New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases - Sit_2011_J.Biol.Chem_286_19422 |
| Author(s) : Sit RK , Radic Z , Gerardi V , Zhang L , Garcia E , Katalinic M , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Journal of Biological Chemistry , 286 :19422 , 2011 |
| Abstract : |
| PubMedSearch : Sit_2011_J.Biol.Chem_286_19422 |
| PubMedID: 21464125 |
| Title : Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase - Radic_2010_Chem.Biol.Interact_187_163 |
| Author(s) : Radic Z , Kalisiak J , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 187 :163 , 2010 |
| Abstract : |
| PubMedSearch : Radic_2010_Chem.Biol.Interact_187_163 |
| PubMedID: 20412789 |
| Title : Probing gorge dimensions of cholinesterases by freeze-frame click chemistry - Radic_2008_Chem.Biol.Interact_175_161 |
| Author(s) : Radic Z , Manetsch R , Fournier D , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 175 :161 , 2008 |
| Abstract : |
| PubMedSearch : Radic_2008_Chem.Biol.Interact_175_161 |
| PubMedID: 18555981 |
| Title : In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors - Krasinski_2005_J.Am.Chem.Soc_127_6686 |
| Author(s) : Krasinski A , Radic Z , Manetsch R , Raushel J , Taylor P , Sharpless KB , Kolb HC |
| Ref : Journal of the American Chemical Society , 127 :6686 , 2005 |
| Abstract : |
| PubMedSearch : Krasinski_2005_J.Am.Chem.Soc_127_6686 |
| PubMedID: 15869290 |
| Title : Molecular basis of interactions of cholinesterases with tight binding inhibitors - Radic_2005_Chem.Biol.Interact_157-158_133 |
| Author(s) : Radic Z , Manetsch R , Krasinski A , Raushel J , Yamauchi J , Garcia C , Kolb HC , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 157-158 :133 , 2005 |
| Abstract : |
| PubMedSearch : Radic_2005_Chem.Biol.Interact_157-158_133 |
| PubMedID: 16289416 |
| Title : Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE - Bourne_2005_Chem.Biol.Interact_157-158_159 |
| Author(s) : Bourne Y , Radic Z , Kolb HC , Sharpless KB , Taylor P , Marchot P |
| Ref : Chemico-Biological Interactions , 157-158 :159 , 2005 |
| Abstract : |
| PubMedSearch : Bourne_2005_Chem.Biol.Interact_157-158_159 |
| PubMedID: 16259971 |
| Title : Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation - Bourne_2004_Proc.Natl.Acad.Sci.U.S.A_101_1449 |
| Author(s) : Bourne Y , Kolb HC , Radic Z , Sharpless KB , Taylor P , Marchot P |
| Ref : Proc Natl Acad Sci U S A , 101 :1449 , 2004 |
| Abstract : |
| PubMedSearch : Bourne_2004_Proc.Natl.Acad.Sci.U.S.A_101_1449 |
| PubMedID: 14757816 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Poster (51) Novel compounds with distinctive interactions at the acetylcholinesterase peripheral anionic site - |
| Author(s) : Bourne Y , Taylor P , Radic Z , Lewis WG , Grynszpan F , Finn MG , Sharpless KB , Marchot P |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :348 , 2004 |
| PubMedID: |
| Title : In situ click chemistry: enzyme inhibitors made to their own specifications - Manetsch_2004_J.Am.Chem.Soc_126_12809 |
| Author(s) : Manetsch R , Krasinski A , Radic Z , Raushel J , Taylor P , Sharpless KB , Kolb HC |
| Ref : Journal of the American Chemical Society , 126 :12809 , 2004 |
| Abstract : |
| PubMedSearch : Manetsch_2004_J.Am.Chem.Soc_126_12809 |
| PubMedID: 15469276 |
| Title : Cover picture: angew. Chem. Int. Ed. 6\/2002 - Lewis_2002_Angew.Chem.Int.Ed.Engl_41_875 |
| Author(s) : Lewis WG , Green LG , Grynszpan F , Radic Z , Carlier PR , Taylor P , Finn MG , Sharpless KB |
| Ref : Angew Chem Int Ed Engl , 41 :875 , 2002 |
| Abstract : |
| PubMedSearch : Lewis_2002_Angew.Chem.Int.Ed.Engl_41_875 |
| PubMedID: |
| Title : Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks - |
| Author(s) : Lewis WG , Green LG , Grynszpan F , Radic Z , Carlier PR , Taylor P , Finn MG , Sharpless KB |
| Ref : Angew Chem Int Ed Engl , 41 :1053 , 2002 |
| PubMedID: 12491310 |