Octanoyl-ghrelin

Ghrelin is a 28 amino acid peptide hormone whose active form is esterified at Ser 3 with octanoic acid. Octanoyl-ghrelin stimulates feeding. platelet activating factor (PAF) acetylhydrolase, carboxypeptidase, cholinesterase and Notum exhibit ghrelin deacylase activity. Gastric MLTRP is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin. Here the InChIKey and CID are for [Des-octanoyl]-Ghrelin

General

Type : Acyl peptide

Chemical_Nomenclature : octanoyl ghrelin\; [O-n-octanoyl-Ser3]-human ghrelin

Canonical SMILES :

InChI :

InChIKey : BGHSOEHUOOAYMY-JTZMCQEISA-N

Other name(s) : Acyl-ghrelin  ||  Gastric MLTRP  ||  Motilin-related peptide  ||  Human ghrelin  ||  [Des-octanoyl]-Ghrelin (human)


MW :

Formula :

CAS_number :

PubChem :

UniChem : BGHSOEHUOOAYMY-JTZMCQEISA-N

Wikipedia : Ghrelin

Target

Structures : 6ZYF

Families : BCHE, Pectinacetylesterase-Notum

References (48)

Title : Sex-specific aggressive and emotional behavior in myostatin-deficient mice: ratio of acylated versus unacylated ghrelin is reduced, but not correlated with butyrylcholinesterase activity level, however parvalbumin expression is lost in the habenular complex - Vernus_2025_Chem.Biol.Interact_15ChEPon__111813
Author(s) : Vernus B , Goustard B , Chabi B , Bertrand-Gaday C , Maillet H , Cash MK , Delobel P , Cerda S , Macart M , Bonnieu A , Darvesh S , Chatonnet A
Ref : Chemico-Biological Interactions , :111813 , 2025
Abstract :
PubMedSearch : Vernus_2025_Chem.Biol.Interact_15ChEPon__111813
PubMedID: 41205668
Gene_locus related to this paper: human-BCHE

Title : Sex-specific aggressive and emotional behavior in myostatin-deficient mice: ratio of acylated versus unacylated ghrelin is reduced, but not correlated with butyrylcholinesterase activity level, however parvalbumin expression is lost in the habenular complex - Vernus_2025_Chem.Biol.Interact_15ChEPon__111813
Author(s) : Vernus B , Goustard B , Chabi B , Bertrand-Gaday C , Maillet H , Cash MK , Delobel P , Cerda S , Macart M , Bonnieu A , Darvesh S , Chatonnet A
Ref : Chemico-Biological Interactions , :111813 , 2025
Abstract :
PubMedSearch : Vernus_2025_Chem.Biol.Interact_15ChEPon__111813
PubMedID: 41205668
Gene_locus related to this paper: human-BCHE

Title : Sex-specific aggressive and emotional behavior in myostatin-deficient mice: ratio of acylated versus unacylated ghrelin is reduced, but not correlated with butyrylcholinesterase activity level, however parvalbumin expression is lost in the habenular complex - Vernus_2025_Chem.Biol.Interact_15ChEPon__111813
Author(s) : Vernus B , Goustard B , Chabi B , Bertrand-Gaday C , Maillet H , Cash MK , Delobel P , Cerda S , Macart M , Bonnieu A , Darvesh S , Chatonnet A
Ref : Chemico-Biological Interactions , :111813 , 2025
Abstract :
PubMedSearch : Vernus_2025_Chem.Biol.Interact_15ChEPon__111813
PubMedID: 41205668
Gene_locus related to this paper: human-BCHE

Title : Notum Deacylates Octanoylated Ghrelin - Zhao_2021_Mol.Metab__101201
Author(s) : Zhao Y , Schuhmacher LN , Roberts M , Kakugawa S , Bineva-Todd G , Howell S , O'Reilly N , Perret C , Snijders AP , Vincent JP , Jones EY
Ref : Mol Metab , :101201 , 2021
Abstract :
PubMedSearch : Zhao_2021_Mol.Metab__101201
PubMedID: 33647468
Gene_locus related to this paper: human-NOTUM

Title : Notum Deacylates Octanoylated Ghrelin - Zhao_2021_Mol.Metab__101201
Author(s) : Zhao Y , Schuhmacher LN , Roberts M , Kakugawa S , Bineva-Todd G , Howell S , O'Reilly N , Perret C , Snijders AP , Vincent JP , Jones EY
Ref : Mol Metab , :101201 , 2021
Abstract :
PubMedSearch : Zhao_2021_Mol.Metab__101201
PubMedID: 33647468
Gene_locus related to this paper: human-NOTUM

Title : Notum Deacylates Octanoylated Ghrelin - Zhao_2021_Mol.Metab__101201
Author(s) : Zhao Y , Schuhmacher LN , Roberts M , Kakugawa S , Bineva-Todd G , Howell S , O'Reilly N , Perret C , Snijders AP , Vincent JP , Jones EY
Ref : Mol Metab , :101201 , 2021
Abstract :
PubMedSearch : Zhao_2021_Mol.Metab__101201
PubMedID: 33647468
Gene_locus related to this paper: human-NOTUM

Title : Ghrelin Octanoylation Is Completely Stabilized in Biological Samples by Alkyl Fluorophosphonates - McGovern-Gooch_2016_Endocrinology_157_4330
Author(s) : McGovern-Gooch KR , Rodrigues T , Darling JE , Sieburg MA , Abizaid A , Hougland JL
Ref : Endocrinology , 157 :4330 , 2016
Abstract :
PubMedSearch : McGovern-Gooch_2016_Endocrinology_157_4330
PubMedID: 27623288

Title : Ghrelin Octanoylation Is Completely Stabilized in Biological Samples by Alkyl Fluorophosphonates - McGovern-Gooch_2016_Endocrinology_157_4330
Author(s) : McGovern-Gooch KR , Rodrigues T , Darling JE , Sieburg MA , Abizaid A , Hougland JL
Ref : Endocrinology , 157 :4330 , 2016
Abstract :
PubMedSearch : McGovern-Gooch_2016_Endocrinology_157_4330
PubMedID: 27623288

Title : Ghrelin Octanoylation Is Completely Stabilized in Biological Samples by Alkyl Fluorophosphonates - McGovern-Gooch_2016_Endocrinology_157_4330
Author(s) : McGovern-Gooch KR , Rodrigues T , Darling JE , Sieburg MA , Abizaid A , Hougland JL
Ref : Endocrinology , 157 :4330 , 2016
Abstract :
PubMedSearch : McGovern-Gooch_2016_Endocrinology_157_4330
PubMedID: 27623288

Title : Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin - Schopfer_2015_Gen.Comp.Endocrinol_224_61
Author(s) : Schopfer LM , Lockridge O , Brimijoin S
Ref : General & Comparative Endocrinology , 224 :61 , 2015
Abstract :
PubMedSearch : Schopfer_2015_Gen.Comp.Endocrinol_224_61
PubMedID: 26073531

Title : Radiometric assay of ghrelin hydrolase activity and (3)H-ghrelin distribution into mouse tissues - Chen_2015_Biochem.Pharmacol_98_732
Author(s) : Chen VP , Gao Y , Geng L , Brimijoin S
Ref : Biochemical Pharmacology , 98 :732 , 2015
Abstract :
PubMedSearch : Chen_2015_Biochem.Pharmacol_98_732
PubMedID: 26514871

Title : The acylated (AG) to unacylated (UAG) ghrelin ratio in esterase inhibitor-treated blood is higher than previously described - Delhanty_2015_Clin.Endocrinol.(Oxf)_82_142
Author(s) : Delhanty PJ , Huisman M , Julien M , Mouchain K , Brune P , Themmen AP , Abribat T , van der Lely AJ
Ref : Clinical Endocrinology (Oxf) , 82 :142 , 2015
Abstract :
PubMedSearch : Delhanty_2015_Clin.Endocrinol.(Oxf)_82_142
PubMedID: 24810977

Title : Plasma butyrylcholinesterase regulates ghrelin to control aggression - Chen_2015_Proc.Natl.Acad.Sci.U.S.A_112_2251
Author(s) : Chen VP , Gao Y , Geng L , Parks RJ , Pang YP , Brimijoin S
Ref : Proc Natl Acad Sci U S A , 112 :2251 , 2015
Abstract :
PubMedSearch : Chen_2015_Proc.Natl.Acad.Sci.U.S.A_112_2251
PubMedID: 25646463

Title : The acylated (AG) to unacylated (UAG) ghrelin ratio in esterase inhibitor-treated blood is higher than previously described - Delhanty_2015_Clin.Endocrinol.(Oxf)_82_142
Author(s) : Delhanty PJ , Huisman M , Julien M , Mouchain K , Brune P , Themmen AP , Abribat T , van der Lely AJ
Ref : Clinical Endocrinology (Oxf) , 82 :142 , 2015
Abstract :
PubMedSearch : Delhanty_2015_Clin.Endocrinol.(Oxf)_82_142
PubMedID: 24810977

Title : Plasma butyrylcholinesterase regulates ghrelin to control aggression - Chen_2015_Proc.Natl.Acad.Sci.U.S.A_112_2251
Author(s) : Chen VP , Gao Y , Geng L , Parks RJ , Pang YP , Brimijoin S
Ref : Proc Natl Acad Sci U S A , 112 :2251 , 2015
Abstract :
PubMedSearch : Chen_2015_Proc.Natl.Acad.Sci.U.S.A_112_2251
PubMedID: 25646463

Title : Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase - Chen_2015_Biochem.J_466_243
Author(s) : Chen X , Huang X , Geng L , Xue L , Hou S , Zheng X , Brimijoin S , Zheng F , Zhan CG
Ref : Biochemical Journal , 466 :243 , 2015
Abstract :
PubMedSearch : Chen_2015_Biochem.J_466_243
PubMedID: 25486543
Gene_locus related to this paper: human-BCHE

Title : Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase - Chen_2015_Biochem.J_466_243
Author(s) : Chen X , Huang X , Geng L , Xue L , Hou S , Zheng X , Brimijoin S , Zheng F , Zhan CG
Ref : Biochemical Journal , 466 :243 , 2015
Abstract :
PubMedSearch : Chen_2015_Biochem.J_466_243
PubMedID: 25486543
Gene_locus related to this paper: human-BCHE

Title : Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin - Schopfer_2015_Gen.Comp.Endocrinol_224_61
Author(s) : Schopfer LM , Lockridge O , Brimijoin S
Ref : General & Comparative Endocrinology , 224 :61 , 2015
Abstract :
PubMedSearch : Schopfer_2015_Gen.Comp.Endocrinol_224_61
PubMedID: 26073531

Title : Radiometric assay of ghrelin hydrolase activity and (3)H-ghrelin distribution into mouse tissues - Chen_2015_Biochem.Pharmacol_98_732
Author(s) : Chen VP , Gao Y , Geng L , Brimijoin S
Ref : Biochemical Pharmacology , 98 :732 , 2015
Abstract :
PubMedSearch : Chen_2015_Biochem.Pharmacol_98_732
PubMedID: 26514871

Title : Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase - Chen_2015_Biochem.J_466_243
Author(s) : Chen X , Huang X , Geng L , Xue L , Hou S , Zheng X , Brimijoin S , Zheng F , Zhan CG
Ref : Biochemical Journal , 466 :243 , 2015
Abstract :
PubMedSearch : Chen_2015_Biochem.J_466_243
PubMedID: 25486543
Gene_locus related to this paper: human-BCHE

Title : The acylated (AG) to unacylated (UAG) ghrelin ratio in esterase inhibitor-treated blood is higher than previously described - Delhanty_2015_Clin.Endocrinol.(Oxf)_82_142
Author(s) : Delhanty PJ , Huisman M , Julien M , Mouchain K , Brune P , Themmen AP , Abribat T , van der Lely AJ
Ref : Clinical Endocrinology (Oxf) , 82 :142 , 2015
Abstract :
PubMedSearch : Delhanty_2015_Clin.Endocrinol.(Oxf)_82_142
PubMedID: 24810977

Title : Plasma butyrylcholinesterase regulates ghrelin to control aggression - Chen_2015_Proc.Natl.Acad.Sci.U.S.A_112_2251
Author(s) : Chen VP , Gao Y , Geng L , Parks RJ , Pang YP , Brimijoin S
Ref : Proc Natl Acad Sci U S A , 112 :2251 , 2015
Abstract :
PubMedSearch : Chen_2015_Proc.Natl.Acad.Sci.U.S.A_112_2251
PubMedID: 25646463

Title : Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin - Schopfer_2015_Gen.Comp.Endocrinol_224_61
Author(s) : Schopfer LM , Lockridge O , Brimijoin S
Ref : General & Comparative Endocrinology , 224 :61 , 2015
Abstract :
PubMedSearch : Schopfer_2015_Gen.Comp.Endocrinol_224_61
PubMedID: 26073531

Title : Radiometric assay of ghrelin hydrolase activity and (3)H-ghrelin distribution into mouse tissues - Chen_2015_Biochem.Pharmacol_98_732
Author(s) : Chen VP , Gao Y , Geng L , Brimijoin S
Ref : Biochemical Pharmacology , 98 :732 , 2015
Abstract :
PubMedSearch : Chen_2015_Biochem.Pharmacol_98_732
PubMedID: 26514871

Title : Pitfalls in the determination of human acylated ghrelin plasma concentrations using a double antibody enzyme immunometric assay - Trivedi_2012_Clin.Biochem_45_178
Author(s) : Trivedi A , Babic S , Chanoine JP
Ref : Clinical Biochemistry , 45 :178 , 2012
Abstract :
PubMedSearch : Trivedi_2012_Clin.Biochem_45_178
PubMedID: 22100897

Title : Pitfalls in the determination of human acylated ghrelin plasma concentrations using a double antibody enzyme immunometric assay - Trivedi_2012_Clin.Biochem_45_178
Author(s) : Trivedi A , Babic S , Chanoine JP
Ref : Clinical Biochemistry , 45 :178 , 2012
Abstract :
PubMedSearch : Trivedi_2012_Clin.Biochem_45_178
PubMedID: 22100897

Title : Pitfalls in the determination of human acylated ghrelin plasma concentrations using a double antibody enzyme immunometric assay - Trivedi_2012_Clin.Biochem_45_178
Author(s) : Trivedi A , Babic S , Chanoine JP
Ref : Clinical Biochemistry , 45 :178 , 2012
Abstract :
PubMedSearch : Trivedi_2012_Clin.Biochem_45_178
PubMedID: 22100897

Title : Obesity and variants of the GHRL (ghrelin) and BCHE (butyrylcholinesterase) genes - Dantas_2011_Genet.Mol.Biol_34_205
Author(s) : Dantas VG , Furtado-Alle L , de Souza RLR , Chautard-Freire-Maia EA
Ref : Genet Mol Biol , 34 :205 , 2011
Abstract :
PubMedSearch : Dantas_2011_Genet.Mol.Biol_34_205
PubMedID: 21734817

Title : High-fat diet with acyl-ghrelin treatment leads to weight gain with low inflammation, high oxidative capacity and normal triglycerides in rat muscle - Barazzoni_2011_PLoS.One_6_e26224
Author(s) : Barazzoni R , Zanetti M , Semolic A , Cattin MR , Pirulli A , Cattin L , Guarnieri G
Ref : PLoS ONE , 6 :e26224 , 2011
Abstract :
PubMedSearch : Barazzoni_2011_PLoS.One_6_e26224
PubMedID: 22039445

Title : Obesity and variants of the GHRL (ghrelin) and BCHE (butyrylcholinesterase) genes - Dantas_2011_Genet.Mol.Biol_34_205
Author(s) : Dantas VG , Furtado-Alle L , de Souza RLR , Chautard-Freire-Maia EA
Ref : Genet Mol Biol , 34 :205 , 2011
Abstract :
PubMedSearch : Dantas_2011_Genet.Mol.Biol_34_205
PubMedID: 21734817

Title : High-fat diet with acyl-ghrelin treatment leads to weight gain with low inflammation, high oxidative capacity and normal triglycerides in rat muscle - Barazzoni_2011_PLoS.One_6_e26224
Author(s) : Barazzoni R , Zanetti M , Semolic A , Cattin MR , Pirulli A , Cattin L , Guarnieri G
Ref : PLoS ONE , 6 :e26224 , 2011
Abstract :
PubMedSearch : Barazzoni_2011_PLoS.One_6_e26224
PubMedID: 22039445

Title : Obesity and variants of the GHRL (ghrelin) and BCHE (butyrylcholinesterase) genes - Dantas_2011_Genet.Mol.Biol_34_205
Author(s) : Dantas VG , Furtado-Alle L , de Souza RLR , Chautard-Freire-Maia EA
Ref : Genet Mol Biol , 34 :205 , 2011
Abstract :
PubMedSearch : Dantas_2011_Genet.Mol.Biol_34_205
PubMedID: 21734817

Title : High-fat diet with acyl-ghrelin treatment leads to weight gain with low inflammation, high oxidative capacity and normal triglycerides in rat muscle - Barazzoni_2011_PLoS.One_6_e26224
Author(s) : Barazzoni R , Zanetti M , Semolic A , Cattin MR , Pirulli A , Cattin L , Guarnieri G
Ref : PLoS ONE , 6 :e26224 , 2011
Abstract :
PubMedSearch : Barazzoni_2011_PLoS.One_6_e26224
PubMedID: 22039445

Title : Ghrelin octanoylation mediated by an orphan lipid transferase - Gutierrez_2008_Proc.Natl.Acad.Sci.U.S.A_105_6320
Author(s) : Gutierrez JA , Solenberg PJ , Perkins DR , Willency JA , Knierman MD , Jin Z , Witcher DR , Luo S , Onyia JE , Hale JE
Ref : Proc Natl Acad Sci U S A , 105 :6320 , 2008
Abstract :
PubMedSearch : Gutierrez_2008_Proc.Natl.Acad.Sci.U.S.A_105_6320
PubMedID: 18443287

Title : The butyrylcholinesterase knockout mouse is obese on a high-fat diet - Li_2008_Chem.Biol.Interact_175_88
Author(s) : Li B , Duysen EG , Lockridge O
Ref : Chemico-Biological Interactions , 175 :88 , 2008
Abstract :
PubMedSearch : Li_2008_Chem.Biol.Interact_175_88
PubMedID: 18452903

Title : Ghrelin octanoylation mediated by an orphan lipid transferase - Gutierrez_2008_Proc.Natl.Acad.Sci.U.S.A_105_6320
Author(s) : Gutierrez JA , Solenberg PJ , Perkins DR , Willency JA , Knierman MD , Jin Z , Witcher DR , Luo S , Onyia JE , Hale JE
Ref : Proc Natl Acad Sci U S A , 105 :6320 , 2008
Abstract :
PubMedSearch : Gutierrez_2008_Proc.Natl.Acad.Sci.U.S.A_105_6320
PubMedID: 18443287

Title : The butyrylcholinesterase knockout mouse is obese on a high-fat diet - Li_2008_Chem.Biol.Interact_175_88
Author(s) : Li B , Duysen EG , Lockridge O
Ref : Chemico-Biological Interactions , 175 :88 , 2008
Abstract :
PubMedSearch : Li_2008_Chem.Biol.Interact_175_88
PubMedID: 18452903

Title : Ghrelin octanoylation mediated by an orphan lipid transferase - Gutierrez_2008_Proc.Natl.Acad.Sci.U.S.A_105_6320
Author(s) : Gutierrez JA , Solenberg PJ , Perkins DR , Willency JA , Knierman MD , Jin Z , Witcher DR , Luo S , Onyia JE , Hale JE
Ref : Proc Natl Acad Sci U S A , 105 :6320 , 2008
Abstract :
PubMedSearch : Gutierrez_2008_Proc.Natl.Acad.Sci.U.S.A_105_6320
PubMedID: 18443287

Title : The butyrylcholinesterase knockout mouse is obese on a high-fat diet - Li_2008_Chem.Biol.Interact_175_88
Author(s) : Li B , Duysen EG , Lockridge O
Ref : Chemico-Biological Interactions , 175 :88 , 2008
Abstract :
PubMedSearch : Li_2008_Chem.Biol.Interact_175_88
PubMedID: 18452903

Title : A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India - Manoharan_2007_Clin.Chim.Acta_378_128
Author(s) : Manoharan I , Boopathy R , Darvesh S , Lockridge O
Ref : Clinica Chimica Acta , 378 :128 , 2007
Abstract :
PubMedSearch : Manoharan_2007_Clin.Chim.Acta_378_128
PubMedID: 17182021

Title : Ghrelin interacts with human plasma lipoproteins - De Vriese_2007_Endocrinology_148_2355
Author(s) : De Vriese C , Hacquebard M , Gregoire F , Carpentier Y , Delporte C
Ref : Endocrinology , 148 :2355 , 2007
Abstract :
PubMedSearch : De Vriese_2007_Endocrinology_148_2355
PubMedID: 17289852

Title : A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India - Manoharan_2007_Clin.Chim.Acta_378_128
Author(s) : Manoharan I , Boopathy R , Darvesh S , Lockridge O
Ref : Clinica Chimica Acta , 378 :128 , 2007
Abstract :
PubMedSearch : Manoharan_2007_Clin.Chim.Acta_378_128
PubMedID: 17182021

Title : Ghrelin interacts with human plasma lipoproteins - De Vriese_2007_Endocrinology_148_2355
Author(s) : De Vriese C , Hacquebard M , Gregoire F , Carpentier Y , Delporte C
Ref : Endocrinology , 148 :2355 , 2007
Abstract :
PubMedSearch : De Vriese_2007_Endocrinology_148_2355
PubMedID: 17289852

Title : A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India - Manoharan_2007_Clin.Chim.Acta_378_128
Author(s) : Manoharan I , Boopathy R , Darvesh S , Lockridge O
Ref : Clinica Chimica Acta , 378 :128 , 2007
Abstract :
PubMedSearch : Manoharan_2007_Clin.Chim.Acta_378_128
PubMedID: 17182021

Title : Ghrelin interacts with human plasma lipoproteins - De Vriese_2007_Endocrinology_148_2355
Author(s) : De Vriese C , Hacquebard M , Gregoire F , Carpentier Y , Delporte C
Ref : Endocrinology , 148 :2355 , 2007
Abstract :
PubMedSearch : De Vriese_2007_Endocrinology_148_2355
PubMedID: 17289852

Title : Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites - De Vriese_2004_Endocrinology_145_4997
Author(s) : De Vriese C , Gregoire F , Lema-Kisoka R , Waelbroeck M , Robberecht P , Delporte C
Ref : Endocrinology , 145 :4997 , 2004
Abstract :
PubMedSearch : De Vriese_2004_Endocrinology_145_4997
PubMedID: 15256494

Title : Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites - De Vriese_2004_Endocrinology_145_4997
Author(s) : De Vriese C , Gregoire F , Lema-Kisoka R , Waelbroeck M , Robberecht P , Delporte C
Ref : Endocrinology , 145 :4997 , 2004
Abstract :
PubMedSearch : De Vriese_2004_Endocrinology_145_4997
PubMedID: 15256494

Title : Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites - De Vriese_2004_Endocrinology_145_4997
Author(s) : De Vriese C , Gregoire F , Lema-Kisoka R , Waelbroeck M , Robberecht P , Delporte C
Ref : Endocrinology , 145 :4997 , 2004
Abstract :
PubMedSearch : De Vriese_2004_Endocrinology_145_4997
PubMedID: 15256494