Polyhydroxyalkanoate

Polyhydroxyalkanoates or PHAs are polyesters produced in nature by numerous microorganisms such as Cupriavidus necator. Polyesters are deposited in the form of highly refractive granules in the cells. PHA synthases are the key enzymes of PHA biosynthesis. They use the coenzyme A - thioester of (r)-hydroxy fatty acids as substrates
Substrate Main targeted enzyme families Type Structure
P(3HB-co-LA) Polyhydroxyalkanoate Natural Polymer
P(3HB-co-4HB) PHA_synth_I Polyhydroxyalkanoate Natural Polymer
P(3HB-co-3HHx) PHA_synth_I PHA_synth_II Polyhydroxyalkanoate Natural Polymer Hexanoate
PHB-Dimer 6_AlphaBeta_hydrolase Natural Polymer Polyhydroxyalkanoate
unsaturated-poly-3-hydroxynonanoate 5_AlphaBeta_hydrolase Polyhydroxyalkanoate Polymer
poly-3-hydroxynonanoate 5_AlphaBeta_hydrolase PHA_depolymerase_arom Polyhydroxyalkanoate Polymer
P(3HO) 5_AlphaBeta_hydrolase PHAZ7_phb_depolymerase Extracel-MCL-phaZ PHA_depolymerase_arom Polyhydroxyalkanoate Polymer Natural
P(6HO) 5_AlphaBeta_hydrolase Polyhydroxyalkanoate Polymer Natural
RB3 Esterase_phb_PHAZ PHAZ7_phb_depolymerase Polymer Polyhydroxyalkanoate
PHB Esterase_phb Esterase_phb_PHAZ PHAZ7_phb_depolymerase PolyAspartate-hydrolase PHB_depolymerase_PhaZ PHA_synth_I OHBut_olig_hydro_put Natural Polymer Polyhydroxyalkanoate
Poly(ethylene-adipate) Esterase_phb Polymer Polyhydroxyalkanoate Adipate
PHBV Esterase_phb Bacterial_lip_FamI.5 Extracel-MCL-phaZ Natural Polymer Polyhydroxyalkanoate
P(3HB-co-LA) Polyhydroxyalkanoate Natural Polymer
P(3HB-co-4HB) PHA_synth_I Polyhydroxyalkanoate Natural Polymer
P(3HB-co-3HHx) PHA_synth_I PHA_synth_II Polyhydroxyalkanoate Natural Polymer Hexanoate
PHB-Dimer 6_AlphaBeta_hydrolase Natural Polymer Polyhydroxyalkanoate
unsaturated-poly-3-hydroxynonanoate 5_AlphaBeta_hydrolase Polyhydroxyalkanoate Polymer
poly-3-hydroxynonanoate 5_AlphaBeta_hydrolase PHA_depolymerase_arom Polyhydroxyalkanoate Polymer
P(3HO) 5_AlphaBeta_hydrolase PHAZ7_phb_depolymerase Extracel-MCL-phaZ PHA_depolymerase_arom Polyhydroxyalkanoate Polymer Natural
P(6HO) 5_AlphaBeta_hydrolase Polyhydroxyalkanoate Polymer Natural
RB3 Esterase_phb_PHAZ PHAZ7_phb_depolymerase Polymer Polyhydroxyalkanoate
PHB Esterase_phb Esterase_phb_PHAZ PHAZ7_phb_depolymerase PolyAspartate-hydrolase PHB_depolymerase_PhaZ PHA_synth_I OHBut_olig_hydro_put Natural Polymer Polyhydroxyalkanoate
Poly(ethylene-adipate) Esterase_phb Polymer Polyhydroxyalkanoate Adipate
PHBV Esterase_phb Bacterial_lip_FamI.5 Extracel-MCL-phaZ Natural Polymer Polyhydroxyalkanoate
P(3HB-co-LA) Polyhydroxyalkanoate Natural Polymer
P(3HB-co-4HB) PHA_synth_I Polyhydroxyalkanoate Natural Polymer
P(3HB-co-3HHx) PHA_synth_I PHA_synth_II Polyhydroxyalkanoate Natural Polymer Hexanoate
PHB-Dimer 6_AlphaBeta_hydrolase Natural Polymer Polyhydroxyalkanoate
unsaturated-poly-3-hydroxynonanoate 5_AlphaBeta_hydrolase Polyhydroxyalkanoate Polymer
poly-3-hydroxynonanoate 5_AlphaBeta_hydrolase PHA_depolymerase_arom Polyhydroxyalkanoate Polymer
P(3HO) 5_AlphaBeta_hydrolase PHAZ7_phb_depolymerase Extracel-MCL-phaZ PHA_depolymerase_arom Polyhydroxyalkanoate Polymer Natural
P(6HO) 5_AlphaBeta_hydrolase Polyhydroxyalkanoate Polymer Natural
RB3 Esterase_phb_PHAZ PHAZ7_phb_depolymerase Polymer Polyhydroxyalkanoate
PHB Esterase_phb Esterase_phb_PHAZ PHAZ7_phb_depolymerase PolyAspartate-hydrolase PHB_depolymerase_PhaZ PHA_synth_I OHBut_olig_hydro_put Natural Polymer Polyhydroxyalkanoate
Poly(ethylene-adipate) Esterase_phb Polymer Polyhydroxyalkanoate Adipate
PHBV Esterase_phb Bacterial_lip_FamI.5 Extracel-MCL-phaZ Natural Polymer Polyhydroxyalkanoate