Procaine
Procaine is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
General
Type : Local anesthetic, Drug, Not A\/B H target
Chemical_Nomenclature : 4-Aminobenzoic acid 2-(diethylamino) ethyl ester hydrochloride
Canonical SMILES : CCN(CC)CCOC(=O)C1=CC=C(C=C1)N
InChI : InChI=1S\/C13H20N2O2\/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11\/h5-8H,3-4,9-10,14H2,1-2H3
InChIKey : MFDFERRIHVXMIY-UHFFFAOYSA-N
Other name(s) : Duracaine || Novocain || Novocaine || Spinocaine || Vitamin H3 || Nissocaine || Procain || Procaine, base || Gerovital
MW : 236.31
Formula : C13H20N2O2.HCl
CAS_number : 59-46-1
PubChem : 4914
UniChem : MFDFERRIHVXMIY-UHFFFAOYSA-N
IUPHAR : 4291
Wikipedia : Procaine
Target
Structures : No structure
Families : BCHE, Carb_B_Chordata
References (5)
| Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M |
| Ref : Eur J Pharm Sci , 78 :47 , 2015 |
| Abstract : |
| PubMedSearch : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| PubMedID: 26164127 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
| Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35 |
| Author(s) : Lockridge O |
| Ref : Pharmacol Ther , 47 :35 , 1990 |
| Abstract : |
| PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35 |
| PubMedID: 2195556 |
| Gene_locus related to this paper: human-BCHE |
| Title : Prediction of drug sensitivity in individuals with atypical serum cholinesterase based on in vitro biochemical studies - Valentino_1981_Biochem.Pharmacol_30_1643 |
| Author(s) : Valentino RJ , Lockridge O , Eckerson HW , La Du BN |
| Ref : Biochemical Pharmacology , 30 :1643 , 1981 |
| Abstract : |
| PubMedSearch : Valentino_1981_Biochem.Pharmacol_30_1643 |
| PubMedID: 7271851 |
| Title : Differential inhibition of plasma cholinesterase variants using the dibutyrate analogue of pancuronium bromide - Whittaker_1981_Hum.Hered_31_242 |
| Author(s) : Whittaker M , Britten JJ |
| Ref : Hum Hered , 31 :242 , 1981 |
| Abstract : |
| PubMedSearch : Whittaker_1981_Hum.Hered_31_242 |
| PubMedID: 7287015 |