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Piperazine

Six-membered ring containing two nitrogen atoms at opposite positions in the ring. Building block for many inhibitors of enzymes
Substrate Main targeted enzyme families Type Structure
Piperazine-2-tert-butylcarboxamide Proline_iminopeptidase Carboxamide Piperazine tert-Butyl
(S)-piperazine-2-carboxamide Proline_iminopeptidase Piperazine Carboxamide
Rifapentine Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine Antibiotic
Ketoconazole Arylacetamide_deacetylase Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine Imidazole Dioxolane
Nintedanib Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine
Depalmitoylation-probe-5 ABHD10 LYsophospholipase_carboxylesterase Piperazine Hexadecanoate Benzofuran Oxobutanoate Palmitate Xanthene Fluorescent Probe
mitoDPP-2 ABHD10 Fluorescent Probe Piperazine Benzofuran Xanthene
SAM690 RsbQ-like Strigolactone receptors ligand Piperazine
Sphynolactone-7 RsbQ-like Strigolactone receptors ligand Piperazine Strigolactone
H-SPL7 RsbQ-like Strigolactone receptors ligand Piperazine Strigolactone
carba-H-SPL7 RsbQ-like Strigolactone receptors ligand Piperazine Strigolactone
1'-carba-SPL7 RsbQ-like Strigolactone receptors ligand Piperazine Strigolactone