Imidazole

Substrate	Main targeted enzyme families	Type	Structure
Indoleacryloyl-imidazole	Carboxypeptidase_S10	Imidazole Indole
Lophine-palmitate	Monoglyceridelipase_lysophospholip	Fatty acid ester Water-insoluble medium and long chain ester Hexadecanoate Palmitate Imidazole
Lophine-laurate	Pancreatic_lipase Fungal_carboxylesterase_lipase	Fatty acid ester Water-insoluble medium and long chain ester Hexadecanoate Dodecanoate Laurate Imidazole
Meso-dimethyl-ester	Epoxide_hydrolase	Imidazole
Candesartan-cilexetil	Carb_B_Chordata	Not AlphaBeta Hydrolase target Drug Pro-Drug Pyrrolidine Angiotensin-receptor blocker Benzimidazole
Triclabendazole-sulfoxide		Benzimidazole Sulfur Compound Organochlorine Anthelmintic
Carbendazim	HNLyase_Bact	Carbamate Benzimidazole
Imidapril	Carb_B_Chordata	Pro-Drug Drug Not AlphaBeta Hydrolase target Imidazole
Ketoconazole	Arylacetamide_deacetylase	Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine Imidazole Dioxolane Organochlorine
Dabigatran-etexilate	Carb_B_Chordata	Pro-Drug Not AlphaBeta Hydrolase target Drug Pyridine Propionate Benzimidazole
Niraparib	Carb_B_Chordata	Not AlphaBeta Hydrolase target Drug Imidazole Piperidine Carboxamide Indazole
Indoleacryloyl-imidazole	Carboxypeptidase_S10	Imidazole Indole
Lophine-palmitate	Monoglyceridelipase_lysophospholip	Fatty acid ester Water-insoluble medium and long chain ester Hexadecanoate Palmitate Imidazole
Lophine-laurate	Pancreatic_lipase Fungal_carboxylesterase_lipase	Fatty acid ester Water-insoluble medium and long chain ester Hexadecanoate Dodecanoate Laurate Imidazole
Meso-dimethyl-ester	Epoxide_hydrolase	Imidazole
Candesartan-cilexetil	Carb_B_Chordata	Not AlphaBeta Hydrolase target Drug Pro-Drug Pyrrolidine Angiotensin-receptor blocker Benzimidazole
Triclabendazole-sulfoxide		Benzimidazole Sulfur Compound Organochlorine Anthelmintic
Carbendazim	HNLyase_Bact	Carbamate Benzimidazole
Imidapril	Carb_B_Chordata	Pro-Drug Drug Not AlphaBeta Hydrolase target Imidazole
Ketoconazole	Arylacetamide_deacetylase	Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine Imidazole Dioxolane Organochlorine
Dabigatran-etexilate	Carb_B_Chordata	Pro-Drug Not AlphaBeta Hydrolase target Drug Pyridine Propionate Benzimidazole
Niraparib	Carb_B_Chordata	Not AlphaBeta Hydrolase target Drug Imidazole Piperidine Carboxamide Indazole
Indoleacryloyl-imidazole	Carboxypeptidase_S10	Imidazole Indole
Lophine-palmitate	Monoglyceridelipase_lysophospholip	Fatty acid ester Water-insoluble medium and long chain ester Hexadecanoate Palmitate Imidazole
Lophine-laurate	Pancreatic_lipase Fungal_carboxylesterase_lipase	Fatty acid ester Water-insoluble medium and long chain ester Hexadecanoate Dodecanoate Laurate Imidazole
Meso-dimethyl-ester	Epoxide_hydrolase	Imidazole
Candesartan-cilexetil	Carb_B_Chordata	Not AlphaBeta Hydrolase target Drug Pro-Drug Pyrrolidine Angiotensin-receptor blocker Benzimidazole
Triclabendazole-sulfoxide		Benzimidazole Sulfur Compound Organochlorine Anthelmintic
Carbendazim	HNLyase_Bact	Carbamate Benzimidazole
Imidapril	Carb_B_Chordata	Pro-Drug Drug Not AlphaBeta Hydrolase target Imidazole
Ketoconazole	Arylacetamide_deacetylase	Pro-Drug Drug Not AlphaBeta Hydrolase target Piperazine Imidazole Dioxolane Organochlorine
Dabigatran-etexilate	Carb_B_Chordata	Pro-Drug Not AlphaBeta Hydrolase target Drug Pyridine Propionate Benzimidazole