Hydrolase_RBBP9_YdeN

Relationship

Family: Hydrolase_RBBP9_YdeN

Block: X

Parent Family: No family

Comment

Retinoblastoma binding protein 9 is an aminopeptidase with a preference for removing aromatic amino acids in human cells (Tang et al.). Ser_hydrolase.Hydrolase_RBBP9/YdeN. Protein of unknown function DUF1234 (old Duf_1234). This family contains Bacillus subtilis yden protein and human retinoblastoma-binding protein 9 (RBBP-9) required for pancreatic neoplasia. Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family.

Database

Interpro : IPR010662 Putative hydrolase RBBP9\/YdeN DUF1234

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF06821 Ser_hydrolase

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (4)

Genes Proteins in Hydrolase_RBBP9_YdeN family (102)

Fragments of genes in Hydrolase_RBBP9_YdeN family (2)

Structures in Hydrolase_RBBP9_YdeN family (4)

No substrate

Inhibitors in Hydrolase_RBBP9_YdeN family (4)

References (16)

Title : Mechanism-based traps enable protease and hydrolase substrate discovery - Tang_2022_Nature_602_701
Author(s) : Tang S , Beattie AT , Kafkova L , Petris G , Huguenin-Dezot N , Fiedler M , Freeman M , Chin JW
Ref : Nature , 602 :701 , 2022
PubMedID: 35173328
Gene_locus related to this paper: human-RBBP9

Title : Application of the RBBP9 Serine Hydrolase Inhibitor, ML114, Decouples Human Pluripotent Stem Cell Proliferation and Differentiation - Lim_2020_Int.J.Mol.Sci_21_8983
Author(s) : Lim S , Shparberg RA , Coorssen JR , O'Connor MD
Ref : Int J Mol Sci , 21 : , 2020
PubMedID: 33256189
Gene_locus related to this paper: human-RBBP9

Title : Chemoproteomic Identification of Serine Hydrolase RBBP9 as a Valacyclovir-Activating Enzyme - Shenoy_2020_Mol.Pharm_17_1706
Author(s) : Shenoy VM , Thompson BR , Shi J , Zhu HJ , Smith DE , Amidon GL
Ref : Mol Pharm , 17 :1706 , 2020
PubMedID: 32196348
Gene_locus related to this paper: human-RBBP9

Title : Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2 - Adachi_2020_Int.Immunol_32_637
Author(s) : Adachi T , Yasuda K , Muto T , Serada S , Yoshimoto T , Ishii KJ , Kuroda E , Araki K , Ohmuraya M , Naka T , Nakanishi K
Ref : Int Immunol , 32 :637 , 2020
PubMedID: 32484881
Gene_locus related to this paper: human-RBBP9

Title : Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers - Vorobiev_2012_Protein.Pept.Lett_19_194
Author(s) : Vorobiev SM , Huang YJ , Seetharaman J , Xiao R , Acton TB , Montelione GT , Tong L
Ref : Protein Pept Lett , 19 :194 , 2012
PubMedID: 21933118
Gene_locus related to this paper: human-RBBP9

Title : Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9 - Liu_2012_Chembiochem_13_2082
Author(s) : Liu X , Dix M , Speers AE , Bachovchin DA , Zuhl AM , Cravatt BF , Kodadek TJ
Ref : Chembiochem , 13 :2082 , 2012
PubMedID: 22907802
Gene_locus related to this paper: human-RBBP9

Title : Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis - Nachmany_2012_Dis.Markers_32_211
Author(s) : Nachmany H , Wald S , Abekasis M , Bulvik S , Weil M
Ref : Dis Markers , 32 :211 , 2012
PubMedID: 22430187
Gene_locus related to this paper: human-RBBP9

Title : Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance - O'Connor_2011_Exp.Hematol_39_866
Author(s) : O'Connor MD , Wederell E , Robertson G , Delaney A , Morozova O , Poon SS , Yap D , Fee J , Zhao Y , McDonald H , Zeng T , Hirst M , Marra MA , Aparicio SA , Eaves CJ
Ref : Experimental Hematology , 39 :866 , 2011
PubMedID: 21689726
Gene_locus related to this paper: human-RBBP9

Title : Probe Report for RBBP9 Inhibitors - Probe 1 - Brown_2010_Probe.Report__
Author(s) : Brown SJ , Bachovchin DA , Cravatt BF , Fernandez-Vega V , Spicer T , Mercer BA , Hodder P , Rosen HR
Ref : Probe Report , : , 2010
PubMedID: 21433353
Gene_locus related to this paper: human-RBBP9

Title : RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia - Shields_2010_Proc.Natl.Acad.Sci.U.S.A_107_2189
Author(s) : Shields DJ , Niessen S , Murphy EA , Mielgo A , Desgrosellier JS , Lau SK , Barnes LA , Lesperance J , Bouvet M , Tarin D , Cravatt BF , Cheresh DA
Ref : Proc Natl Acad Sci U S A , 107 :2189 , 2010
PubMedID: 20080647
Gene_locus related to this paper: human-RBBP9

Title : Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) - Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254
Author(s) : Bachovchin DA , Wolfe MR , Masuda K , Brown SJ , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2254 , 2010
PubMedID: 20207142
Gene_locus related to this paper: human-RBBP9

Title : Probe Report for RBBP9 Inhibitors - Probe 2 - Bachovchin_2010_Probe.Report.1__
Author(s) : Bachovchin DA , Speers AE , Brown SJ , Cravatt BF , Spicer T , Mercer BA , Ferguson J , Hodder P , Rosen HR
Ref : Probe Report , : , 2010
PubMedID: 21433382
Gene_locus related to this paper: human-RBBP9

Title : Crystal structure of human retinoblastoma binding protein 9 -
Author(s) : Vorobiev SM , Su M , Seetharaman J , Huang YJ , Chen CX , Maglaqui M , Janjua H , Proudfoot M , Yakunin A , Xiao R , Acton TB , Montelione GT , Tong L
Ref : Proteins , 74 :526 , 2009
PubMedID: 19004028
Gene_locus related to this paper: human-RBBP9

Title : Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo - Cassie_2006_Carcinogenesis_27_465
Author(s) : Cassie S , Koturbash I , Hudson D , Baker M , Ilnytskyy Y , Rodriguez-Juarez R , Weber E , Kovalchuk O
Ref : Carcinogenesis , 27 :465 , 2006
PubMedID: 16272168
Gene_locus related to this paper: human-RBBP9

Title : Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution - Janda_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1101
Author(s) : Janda I , Devedjiev Y , Cooper D , Chruszcz M , Derewenda U , Gabrys A , Minor W , Joachimiak A , Derewenda ZS
Ref : Acta Crystallographica D Biol Crystallogr , 60 :1101 , 2004
PubMedID: 15159570
Gene_locus related to this paper: bacsu-YDEN

Title : A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability - Woitach_1998_Nat.Genet_19_371
Author(s) : Woitach JT , Zhang M , Niu CH , Thorgeirsson SS
Ref : Nat Genet , 19 :371 , 1998
PubMedID: 9697699
Gene_locus related to this paper: human-RBBP9 , ratno-rbbp9