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mouse-EPHX1

Mus musculus (Mouse) epoxide hydrolase mEH (EC 3.3.2.3)

Comment

Q8K2W5 Stausberg 4 aa different, Q6PEV0 1 del

Relationship

Family : Epoxide_hydrolase

Block : X

Position in NCBI Life Tree : Mus musculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

Database

Sequence

Peptide

MWLELILASV LGFVIYWFVS RDKEETLPLE DGWWGPGSKP SAKEDESIRP FKVETSDEEI KDLHQRIDRF RASPPLEGSR FHYGFNSSYL KKVVSFWRNE FDWRKQVEIL NQYPHFKTKI EGLDIHFIHV KPPQLPSGRT PKPLLMVHGW PGSFYEFYKI IPLLTDPKTH GLSDEHVFEV ICPSIPGYGF SEASSKKGLN SVATARIFYK LMSRLGFQKF YIQGGDWGSL ICTNIAQMVP NHVKGLHLNM SFISRNIYSL TPLLGQRFGR FLGYTEKDLE LLYPFKEKVF YNIMRESGYL HIQATKPDTV GCALNDSPVG LAAYILEKFS TWTKSEYREL EDGGLERKFS LEDLLTNIMI YWTTGTIVSS QRFYKENLGQ GVMVHRHEGM KVFVPTGYSA FPSEILHAPE KWVKVKYPKL ISYSYMERGG HFAAFEEPKL LAQDIRKFVS LAELQ

References (6)

Title : Development of potent inhibitors of the human microsomal epoxide hydrolase - Barnych_2020_Eur.J.Med.Chem_193_112206
Author(s) : Barnych B , Singh N , Negrel S , Zhang Y , Magis D , Roux C , Hua X , Ding Z , Morisseau C , Tantillo DJ , Siegel JB , Hammock BD
Ref : Eur Journal of Medicinal Chemistry , 193 :112206 , 2020
Abstract :
PubMedSearch : Barnych_2020_Eur.J.Med.Chem_193_112206
PubMedID: 32203787
Gene_locus related to this paper: human-EPHX1 , mouse-EPHX1

Title : Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia - Edin_2018_J.Biol.Chem_293_3281
Author(s) : Edin ML , Hamedani BG , Gruzdev A , Graves JP , Lih FB , Arbes SJ, 3rd , Singh R , Orjuela Leon AC , Bradbury JA , DeGraff LM , Hoopes SL , Arand M , Zeldin DC
Ref : Journal of Biological Chemistry , 293 :3281 , 2018
Abstract :
PubMedSearch : Edin_2018_J.Biol.Chem_293_3281
PubMedID: 29298899
Gene_locus related to this paper: mouse-EPHX1 , mouse-hyes

Title : Beyond detoxification: a role for mouse mEH in the hepatic metabolism of endogenous lipids - Marowsky_2017_Arch.Toxicol_91_3571
Author(s) : Marowsky A , Meyer I , Erismann-Ebner K , Pellegrini G , Mule N , Arand M
Ref : Archives of Toxicology , 91 :3571 , 2017
Abstract :
PubMedSearch : Marowsky_2017_Arch.Toxicol_91_3571
PubMedID: 28975360
Gene_locus related to this paper: mouse-EPHX1

Title : Expression and activity of microsomal epoxide hydrolase in follicles isolated from mouse ovaries - Cannady_2002_Toxicol.Sci_68_24
Author(s) : Cannady EA , Dyer CA , Christian PJ , Sipes IG , Hoyer PB
Ref : Toxicol Sci , 68 :24 , 2002
Abstract :
PubMedSearch : Cannady_2002_Toxicol.Sci_68_24
PubMedID: 12075107
Gene_locus related to this paper: mouse-EPHX1

Title : Functional annotation of a full-length mouse cDNA collection - Kawai_2001_Nature_409_685
Author(s) : Kawai J , Shinagawa A , Shibata K , Yoshino M , Itoh M , Ishii Y , Arakawa T , Hara A , Fukunishi Y , Konno H , Adachi J , Fukuda S , Aizawa K , Izawa M , Nishi K , Kiyosawa H , Kondo S , Yamanaka I , Saito T , Okazaki Y , Gojobori T , Bono H , Kasukawa T , Saito R , Kadota K , Matsuda H , Ashburner M , Batalov S , Casavant T , Fleischmann W , Gaasterland T , Gissi C , King B , Kochiwa H , Kuehl P , Lewis S , Matsuo Y , Nikaido I , Pesole G , Quackenbush J , Schriml LM , Staubli F , Suzuki R , Tomita M , Wagner L , Washio T , Sakai K , Okido T , Furuno M , Aono H , Baldarelli R , Barsh G , Blake J , Boffelli D , Bojunga N , Carninci P , de Bonaldo MF , Brownstein MJ , Bult C , Fletcher C , Fujita M , Gariboldi M , Gustincich S , Hill D , Hofmann M , Hume DA , Kamiya M , Lee NH , Lyons P , Marchionni L , Mashima J , Mazzarelli J , Mombaerts P , Nordone P , Ring B , Ringwald M , Rodriguez I , Sakamoto N , Sasaki H , Sato K , Schonbach C , Seya T , Shibata Y , Storch KF , Suzuki H , Toyo-oka K , Wang KH , Weitz C , Whittaker C , Wilming L , Wynshaw-Boris A , Yoshida K , Hasegawa Y , Kawaji H , Kohtsuki S , Hayashizaki Y
Ref : Nature , 409 :685 , 2001
Abstract :
PubMedSearch : Kawai_2001_Nature_409_685
PubMedID: 11217851
Gene_locus related to this paper: mouse-1lipg , mouse-1plip , mouse-1plrp , mouse-ABH15 , mouse-abhd5 , mouse-ABHD6 , mouse-Abhd8 , mouse-aryla , mouse-bphl , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-EPHX1 , mouse-ES10 , mouse-hslip , mouse-hyes , mouse-ABHD2 , mouse-lcat , mouse-lipli , mouse-LIPN , mouse-lypla1 , mouse-lypla2 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-Ppgb , mouse-PPME1 , mouse-ppt , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-RISC , mouse-SERHL , mouse-SPG21 , mouse-Tex30

Title : The Ephx1(d) allele encoding an Arg338Cys substitution is associated with heat lability - Hartsfield_2000_Mamm.Genome_11_915
Author(s) : Hartsfield JK, Jr. , Everett ET
Ref : Mamm Genome , 11 :915 , 2000
Abstract :
PubMedSearch : Hartsfield_2000_Mamm.Genome_11_915
PubMedID: 11003708
Gene_locus related to this paper: mouse-EPHX1