ratno-hyep

Rattus norvegicus (Rat) Epoxide hydrolase 1, Epoxide hydratase

Comment

Relationship

Family : Epoxide_hydrolase

Block : X

Position in NCBI Life Tree : Rattus norvegicus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Rattus N E > Rattus norvegicus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No inhibitor

Database

Sequence

Peptide

MWLELVLASL LGFVIYWFVS RDKEETLPLG DGWWGPGSKP SAKEDESIRP FKVETSDEEI KDLHQRIDRF RASPPLEGSR FHYGFNSNYM KKVVSYWRNE FDWRKQVEIL NQYPHFKTKI EGLDIHFIHV KPPQLPSGRT PKPLLMVHGW PGSFYEFYKI IPLLTDPKSH GLSDEHVFEV ICPSIPGYGY SEASSKKGLN SVATARIFYK LMTRLGFQKF YIQGGDWGSL ICTNMAQMVP NHVKGLHLNM AFISRSFYTM TPLLGQRFGR FLGYTEKDIE LLYPYKEKVF YSIMRESGYL HIQATKPDTV GCALNDSPVG LAAYILEKFS TWTKSEYREL EDGGLERKFS LDDLLVNIMI YWTTGTIVSS QRYYKENLGQ GIMVHKHEGM KVFVPTGFSA FPSELLHAPE KWVKVKYPKL ISYSYMERGG HFAAFEEPKL LAQDIRKFVS LAELQ

References (14)

Title : Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies - Morisseau_2011_Anal.Biochem_414_154
Author(s) : Morisseau C , Bernay M , Escaich A , Sanborn JR , Lango J , Hammock BD
Ref : Analytical Biochemistry , 414 :154 , 2011
PubMedID: 21371418
Gene_locus related to this paper: human-EPHX1 , ratno-hyep

Title : Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase - Morisseau_2008_Chem.Res.Toxicol_21_951
Author(s) : Morisseau C , Newman JW , Wheelock CE , Hill Iii T , Morin D , Buckpitt AR , Hammock BD
Ref : Chemical Research in Toxicology , 21 :951 , 2008
PubMedID: 18363382
Gene_locus related to this paper: human-EPHX1 , ratno-hyep

Title : Genome sequence of the Brown Norway rat yields insights into mammalian evolution - Gibbs_2004_Nature_428_493
Author(s) : Gibbs RA , Weinstock GM , Metzker ML , Muzny DM , Sodergren EJ , Scherer S , Scott G , Steffen D , Worley KC , Burch PE , Okwuonu G , Hines S , Lewis L , DeRamo C , Delgado O , Dugan-Rocha S , Miner G , Morgan M , Hawes A , Gill R , Celera , Holt RA , Adams MD , Amanatides PG , Baden-Tillson H , Barnstead M , Chin S , Evans CA , Ferriera S , Fosler C , Glodek A , Gu Z , Jennings D , Kraft CL , Nguyen T , Pfannkoch CM , Sitter C , Sutton GG , Venter JC , Woodage T , Smith D , Lee HM , Gustafson E , Cahill P , Kana A , Doucette-Stamm L , Weinstock K , Fechtel K , Weiss RB , Dunn DM , Green ED , Blakesley RW , Bouffard GG , de Jong PJ , Osoegawa K , Zhu B , Marra M , Schein J , Bosdet I , Fjell C , Jones S , Krzywinski M , Mathewson C , Siddiqui A , Wye N , McPherson J , Zhao S , Fraser CM , Shetty J , Shatsman S , Geer K , Chen Y , Abramzon S , Nierman WC , Havlak PH , Chen R , Durbin KJ , Egan A , Ren Y , Song XZ , Li B , Liu Y , Qin X , Cawley S , Cooney AJ , D'Souza LM , Martin K , Wu JQ , Gonzalez-Garay ML , Jackson AR , Kalafus KJ , McLeod MP , Milosavljevic A , Virk D , Volkov A , Wheeler DA , Zhang Z , Bailey JA , Eichler EE , Tuzun E , Birney E , Mongin E , Ureta-Vidal A , Woodwark C , Zdobnov E , Bork P , Suyama M , Torrents D , Alexandersson M , Trask BJ , Young JM , Huang H , Wang H , Xing H , Daniels S , Gietzen D , Schmidt J , Stevens K , Vitt U , Wingrove J , Camara F , Mar Alba M , Abril JF , Guigo R , Smit A , Dubchak I , Rubin EM , Couronne O , Poliakov A , Hubner N , Ganten D , Goesele C , Hummel O , Kreitler T , Lee YA , Monti J , Schulz H , Zimdahl H , Himmelbauer H , Lehrach H , Jacob HJ , Bromberg S , Gullings-Handley J , Jensen-Seaman MI , Kwitek AE , Lazar J , Pasko D , Tonellato PJ , Twigger S , Ponting CP , Duarte JM , Rice S , Goodstadt L , Beatson SA , Emes RD , Winter EE , Webber C , Brandt P , Nyakatura G , Adetobi M , Chiaromonte F , Elnitski L , Eswara P , Hardison RC , Hou M , Kolbe D , Makova K , Miller W , Nekrutenko A , Riemer C , Schwartz S , Taylor J , Yang S , Zhang Y , Lindpaintner K , Andrews TD , Caccamo M , Clamp M , Clarke L , Curwen V , Durbin R , Eyras E , Searle SM , Cooper GM , Batzoglou S , Brudno M , Sidow A , Stone EA , Payseur BA , Bourque G , Lopez-Otin C , Puente XS , Chakrabarti K , Chatterji S , Dewey C , Pachter L , Bray N , Yap VB , Caspi A , Tesler G , Pevzner PA , Haussler D , Roskin KM , Baertsch R , Clawson H , Furey TS , Hinrichs AS , Karolchik D , Kent WJ , Rosenbloom KR , Trumbower H , Weirauch M , Cooper DN , Stenson PD , Ma B , Brent M , Arumugam M , Shteynberg D , Copley RR , Taylor MS , Riethman H , Mudunuri U , Peterson J , Guyer M , Felsenfeld A , Old S , Mockrin S , Collins F
Ref : Nature , 428 :493 , 2004
PubMedID: 15057822
Gene_locus related to this paper: rat-abhea , rat-abheb , rat-cd029 , rat-d3zaw4 , rat-dpp9 , rat-d3zhq1 , rat-d3zkp8 , rat-d3zuq1 , rat-d3zxw8 , rat-d4a4w4 , rat-d4a7w1 , rat-d4a9l7 , rat-d4a071 , rat-d4aa31 , rat-d4aa33 , rat-d4aa61 , rat-dglb , rat-f1lz91 , rat-Kansl3 , rat-nceh1 , rat-Tex30 , ratno-1hlip , ratno-1neur , ratno-1plip , ratno-2neur , ratno-3neur , ratno-3plip , ratno-ABH15 , ratno-ACHE , ratno-balip , ratno-BCHE , ratno-cauxin , ratno-Ces1d , ratno-Ces1e , ratno-Ces2f , ratno-d3ze31 , ratno-d3zp14 , ratno-d3zxi3 , ratno-d3zxq0 , ratno-d3zxq1 , ratno-d4a3d4 , ratno-d4aa05 , ratno-dpp4 , ratno-dpp6 , ratno-est8 , ratno-FAP , ratno-hyep , ratno-hyes , ratno-kmcxe , ratno-lmcxe , ratno-LOC246252 , ratno-MGLL , ratno-pbcxe , ratno-phebest , ratno-Ppgb , ratno-q4qr68 , ratno-q6ayr2 , ratno-q6q629 , ratno-SPG21 , ratno-thyro , rat-m0rc77 , rat-a0a0g2k9y7 , rat-a0a0g2kb83 , rat-d3zba8 , rat-d3zbj1 , rat-d3zcr8 , rat-d3zxw5 , rat-d4a340 , rat-f1lvg7 , rat-m0r509 , rat-m0r5d4 , rat-b5den3 , rat-d3zxk4 , rat-d4a1b6 , rat-d3zmg4 , rat-ab17c

Title : Organellar proteomics reveals Golgi arginine dimethylation - Wu_2004_Mol.Biol.Cell_15_2907
Author(s) : Wu CC , Maccoss MJ , Mardones G , Finnigan C , Mogelsvang S , Yates JR, 3rd , Howell KE
Ref : Mol Biology of the cell , 15 :2907 , 2004
PubMedID: 15047867
Gene_locus related to this paper: ratno-hyep

Title : Catalytic triad of microsomal epoxide hydrolase: replacement of Glu404 with Asp leads to a strongly increased turnover rate - Arand_1999_Biochem.J_337 ( Pt 1)_37
Author(s) : Arand M , Muller F , Mecky A , Hinz W , Urban P , Pompon D , Kellner R , Oesch F
Ref : Biochemical Journal , 337 ( Pt 1) :37 , 1999
PubMedID: 9854022
Gene_locus related to this paper: ratno-hyep

Title : Semifunctional site-specific mutants affecting the hydrolytic half-reaction of microsomal epoxide hydrolase - Tzeng_1998_Biochemistry_37_2905
Author(s) : Tzeng HF , Laughlin LT , Armstrong RN
Ref : Biochemistry , 37 :2905 , 1998
PubMedID: 9485442
Gene_locus related to this paper: ratno-hyep

Title : Mechanism of microsomal epoxide hydrolase. Semifunctional site-specific mutants affecting the alkylation half-reaction - Laughlin_1998_Biochemistry_37_2897
Author(s) : Laughlin LT , Tzeng HF , Lin S , Armstrong RN
Ref : Biochemistry , 37 :2897 , 1998
PubMedID: 9485441
Gene_locus related to this paper: ratno-hyep

Title : Microsomal epoxide hydrolase of rat liver is a subunit of theanti-oestrogen-binding site - Mesange_1998_Biochem.J_334 ( Pt 1)_107
Author(s) : Mesange F , Sebbar M , Kedjouar B , Capdevielle J , Guillemot JC , Ferrara P , Bayard F , Delarue F , Faye JC , Poirot M
Ref : Biochemical Journal , 334 ( Pt 1) :107 , 1998
PubMedID: 9693109
Gene_locus related to this paper: ratno-hyep

Title : The membrane anchor of microsomal epoxide hydrolase from human, rat, and rabbit displays an unexpected membrane topology - Holler_1997_Biochem.Biophys.Res.Commun_236_754
Author(s) : Holler R , Arand M , Mecky A , Oesch F , Friedberg T
Ref : Biochemical & Biophysical Research Communications , 236 :754 , 1997
PubMedID: 9245728
Gene_locus related to this paper: ratno-hyep

Title : Studies on the importance of microsomal epoxide hydrolase in the detoxification of arene oxides using the heterologous expression of the enzyme in mammalian cells - Friedberg_1994_Carcinogenesis_15_171
Author(s) : Friedberg T , Becker R , Oesch F , Glatt H
Ref : Carcinogenesis , 15 :171 , 1994
PubMedID: 8313504
Gene_locus related to this paper: ratno-hyep

Title : Expression of rat microsomal epoxide hydrolase in Escherichia coli. Identification of a histidyl residue essential for catalysis - Bell_1993_J.Biol.Chem_268_14011
Author(s) : Bell PA , Kasper CB
Ref : Journal of Biological Chemistry , 268 :14011 , 1993
PubMedID: 8314768
Gene_locus related to this paper: ratno-hyep

Title : Structure and organization of the microsomal xenobiotic epoxide hydrolase gene - Falany_1987_J.Biol.Chem_262_5924
Author(s) : Falany CN , McQuiddy P , Kasper CB
Ref : Journal of Biological Chemistry , 262 :5924 , 1987
PubMedID: 3032949
Gene_locus related to this paper: ratno-hyep

Title : Complementary DNA and amino acid sequence of rat liver microsomal, xenobiotic epoxide hydrolase - Porter_1986_Arch.Biochem.Biophys_248_121
Author(s) : Porter TD , Beck TW , Kasper CB
Ref : Archives of Biochemistry & Biophysics , 248 :121 , 1986
PubMedID: 3755318
Gene_locus related to this paper: ratno-hyep

Title : Effects of hepatocarcinogens and hepatocarcinogenesis on the activity of rat liver microsomal epoxide hydrolase and observations on the electrophoretic behavior of this enzyme -
Author(s) : Sharma RN , Gurtoo HL , Farber E , Murray RK , Cameron RG
Ref : Cancer Research , 41 :3311 , 1981
PubMedID: 7260898
Gene_locus related to this paper: ratno-hyep