4-methylumbelliferyl-acetate
General
Type : Coumarin, Acetate, Chromen
Chemical_Nomenclature : (4-methyl-2-oxochromen-7-yl) acetate
Canonical SMILES : CC1=CC(=O)OC2=C1C=CC(=C2)OC(=O)C
InChI : InChI=1S\/C12H10O4\/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11\/h3-6H,1-2H3
InChIKey : HXVZGASCDAGAPS-UHFFFAOYSA-N
Other name(s) : 7-Acetoxy-4-methylcoumarin || 4-methylumbelliferyl acetate || 4-Methyl-2-oxo-2H-chromen-7-yl acetate || MUFA || MU-Ac || 4MUA || 4MU-Ac || 4-MU-Ac || 4MU-C2 || 4-MU-Acetate || 4-MU Acetate || B-methylumbelliferyl acetate || 4-methylumbelliferone-acetate || methyl umbelliferyl acetate || 4-Methyl umbelliferone acetate
MW : 218.20
Formula : C12H10O4
CAS_number : 2747-05-9
PubChem : 366
UniChem : HXVZGASCDAGAPS-UHFFFAOYSA-N
Target
Structures : No structure
Families : Carb_B_Chordata, Esterase_phb, A85-EsteraseD-FGH, Acetyl-esterase_deacetylase, Plant_carboxylesterase, 6_AlphaBeta_hydrolase, A85-Feruloyl-Esterase
References (18)
| Title : A novel esterase regulates Klebsiella pneumoniae hypermucoviscosity and virulence - Wang_2024_PLoS.Pathog_20_e1012675 |
| Author(s) : Wang L , Wang Z , Zhang H , Jin Q , Fan S , Liu Y , Huang X , Guo J , Cai C , Zhang JR , Wu H |
| Ref : PLoS Pathog , 20 :e1012675 , 2024 |
| Abstract : |
| PubMedSearch : Wang_2024_PLoS.Pathog_20_e1012675 |
| PubMedID: 39480904 |
| Gene_locus related to this paper: klepn-KpACE |
| Title : Purification and Crystallographic Analysis of a Novel Cold-Active Esterase (HaEst1) from Halocynthiibacter arcticus - Jeon_2021_Crystals_11_170 |
| Author(s) : Jeon S , Hwang J , Yoo W , Chang JW , Do H , Kim HW , Kim KK , Lee JH , Kim TD |
| Ref : Crystals , 11 :170 , 2021 |
| Abstract : |
| PubMedSearch : Jeon_2021_Crystals_11_170 |
| PubMedID: |
| Gene_locus related to this paper: 9rhob-a0a126uwz8 |
| Title : Role of an N-terminal extension in stability and catalytic activity of a hyperthermostable alpha\/beta hydrolase fold esterase - Singh_2017_Protein.Eng.Des.Sel_30_559 |
| Author(s) : Singh MK , Shivakumaraswamy S , Gummadi SN , Manoj N |
| Ref : Protein Engineering Des Sel , 30 :559 , 2017 |
| Abstract : |
| PubMedSearch : Singh_2017_Protein.Eng.Des.Sel_30_559 |
| PubMedID: 28967962 |
| Gene_locus related to this paper: thema-TM0077 |
| Title : Heterologous expression, purification and characterization of three novel esterases secreted by the lignocellulolytic fungus Penicillium purpurogenum when grown on sugar beet pulp - Oleas_2017_Carbohydr.Res_443-444_42 |
| Author(s) : Oleas G , Callegari E , Sepulveda R , Eyzaguirre J |
| Ref : Carbohydr Res , 443-444 :42 , 2017 |
| Abstract : |
| PubMedSearch : Oleas_2017_Carbohydr.Res_443-444_42 |
| PubMedID: 28342968 |
| Gene_locus related to this paper: talpu-a0a0f7kmg2 |
| Title : Crystal structure of Thermotoga maritima acetyl esterase complex with a substrate analog: Insights into the distinctive substrate specificity in the CE7 carbohydrate esterase family - Singh_2016_Biochem.Biophys.Res.Commun_476_63 |
| Author(s) : Singh MK , Manoj N |
| Ref : Biochemical & Biophysical Research Communications , 476 :63 , 2016 |
| Abstract : |
| PubMedSearch : Singh_2016_Biochem.Biophys.Res.Commun_476_63 |
| PubMedID: 27181355 |
| Gene_locus related to this paper: thema-TM0077 |
| Title : An extended loop in CE7 carbohydrate esterase family is dispensable for oligomerization but required for activity and thermostability - Singh_2016_J.Struct.Biol_194_434 |
| Author(s) : Singh MK , Manoj N |
| Ref : J Struct Biol , 194 :434 , 2016 |
| Abstract : |
| PubMedSearch : Singh_2016_J.Struct.Biol_194_434 |
| PubMedID: 27085421 |
| Gene_locus related to this paper: thema-TM0077 |
| Title : Comparative study of the hydrolytic metabolism of methyl-, ethyl-, propyl-, butyl-, heptyl- and dodecylparaben by microsomes of various rat and human tissues - Ozaki_2013_Xenobiotica_43_1064 |
| Author(s) : Ozaki H , Sugihara K , Watanabe Y , Fujino C , Uramaru N , Sone T , Ohta S , Kitamura S |
| Ref : Xenobiotica , 43 :1064 , 2013 |
| Abstract : |
| PubMedSearch : Ozaki_2013_Xenobiotica_43_1064 |
| PubMedID: 23742084 |
| Title : Expression and characterization of a human carboxylesterase 2 splice variant - Schiel_2007_J.Pharmacol.Exp.Ther_323_94 |
| Author(s) : Schiel MA , Green SL , Davis WI , Sanghani PC , Bosron WF , Sanghani SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 323 :94 , 2007 |
| Abstract : |
| PubMedSearch : Schiel_2007_J.Pharmacol.Exp.Ther_323_94 |
| PubMedID: 17636009 |
| Title : Specificity of procaine and ester hydrolysis by human, minipig, and rat skin and liver - Jewell_2007_Drug.Metab.Dispos_35_2015 |
| Author(s) : Jewell C , Ackermann C , Payne NA , Fate G , Voorman R , Williams FM |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 35 :2015 , 2007 |
| Abstract : |
| PubMedSearch : Jewell_2007_Drug.Metab.Dispos_35_2015 |
| PubMedID: 17664252 |
| Title : High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon - Ileperuma_2007_Biochemistry_46_1851 |
| Author(s) : Ileperuma NR , Marshall SD , Squire CJ , Baker HM , Oakeshott JG , Russell RJ , Plummer KM , Newcomb RD , Baker EN |
| Ref : Biochemistry , 46 :1851 , 2007 |
| Abstract : |
| PubMedSearch : Ileperuma_2007_Biochemistry_46_1851 |
| PubMedID: 17256879 |
| Gene_locus related to this paper: actde-CXE1 |
| Title : Molecular cloning, and characterization of a modular acetyl xylan esterase from the edible straw mushroom Volvariella volvacea - Ding_2007_FEMS.Microbiol.Lett_274_304 |
| Author(s) : Ding S , Cao J , Zhou R , Zheng F |
| Ref : FEMS Microbiology Letters , 274 :304 , 2007 |
| Abstract : |
| PubMedSearch : Ding_2007_FEMS.Microbiol.Lett_274_304 |
| PubMedID: 17623028 |
| Title : Unique regulation of the active site of the serine esterase S-formylglutathione hydrolase - Cummins_2006_J.Mol.Biol_359_422 |
| Author(s) : Cummins I , McAuley K , Fordham-Skelton A , Schwoerer R , Steel PG , Davis BG , Edwards R |
| Ref : Journal of Molecular Biology , 359 :422 , 2006 |
| Abstract : |
| PubMedSearch : Cummins_2006_J.Mol.Biol_359_422 |
| PubMedID: 16626737 |
| Gene_locus related to this paper: arath-SFGH |
| Title : Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2) - Kubo_2005_Drug.Metab.Dispos_33_1482 |
| Author(s) : Kubo T , Kim SR , Sai K , Saito Y , Nakajima T , Matsumoto K , Saito H , Shirao K , Yamamoto N , Minami H , Ohtsu A , Yoshida T , Saijo N , Ohno Y , Ozawa S , Sawada J |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 33 :1482 , 2005 |
| Abstract : |
| PubMedSearch : Kubo_2005_Drug.Metab.Dispos_33_1482 |
| PubMedID: 16033949 |
| Title : Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases - Wadkins_2005_J.Med.Chem_48_2906 |
| Author(s) : Wadkins RM , Hyatt JL , Wei X , Yoon KJ , Wierdl M , Edwards CC , Morton CL , Obenauer JC , Damodaran K , Beroza P , Danks MK , Potter PM |
| Ref : Journal of Medicinal Chemistry , 48 :2906 , 2005 |
| Abstract : |
| PubMedSearch : Wadkins_2005_J.Med.Chem_48_2906 |
| PubMedID: 15828829 |
| Title : Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes - Wheelock_2003_Anal.Biochem_315_208 |
| Author(s) : Wheelock CE , Wheelock AM , Zhang R , Stok JE , Morisseau C , Le Valley SE , Green CE , Hammock BD |
| Ref : Analytical Biochemistry , 315 :208 , 2003 |
| Abstract : |
| PubMedSearch : Wheelock_2003_Anal.Biochem_315_208 |
| PubMedID: 12689831 |
| Gene_locus related to this paper: mouse-Ces2e |
| Title : Cloning and characterization of an S-formylglutathione hydrolase from Arabidopsis thaliana - Kordic_2002_Arch.Biochem.Biophys_399_232 |
| Author(s) : Kordic S , Cummins I , Edwards R |
| Ref : Archives of Biochemistry & Biophysics , 399 :232 , 2002 |
| Abstract : |
| PubMedSearch : Kordic_2002_Arch.Biochem.Biophys_399_232 |
| PubMedID: 11888210 |
| Gene_locus related to this paper: arath-SFGH |
| Title : S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification. - Harms_1996_J.Bacteriol_178_6296 |
| Author(s) : Harms N , Ras J , Reijnders WNM , van Spanning RJM , Stouthamer AH |
| Ref : Journal of Bacteriology , 178 :6296 , 1996 |
| Abstract : |
| PubMedSearch : Harms_1996_J.Bacteriol_178_6296 |
| PubMedID: 8892832 |
| Gene_locus related to this paper: parde-FGHA |
| Title : Purification and characterization of two thermostable acetyl xylan esterases from Thermoanaerobacterium sp. strain JW\/SL-YS485 - Shao_1995_Appl.Environ.Microbiol_61_729 |
| Author(s) : Shao W , Wiegel J |
| Ref : Applied Environmental Microbiology , 61 :729 , 1995 |
| Abstract : |
| PubMedSearch : Shao_1995_Appl.Environ.Microbiol_61_729 |
| PubMedID: 7574610 |
| Gene_locus related to this paper: thesj-AXE1 |