Haemmerle G

References (46)

Title : Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism - Chalhoub_2023_Mol.Metab__101725
Author(s) : Chalhoub G , Jamnik A , Pajed L , Kolleritsch S , Hois V , Bagaric A , Prem D , Tilp A , Kolb D , Wolinski H , Taschler U , Zullig T , Rechberger GN , Fuchs C , Trauner M , Schoiswohl G , Haemmerle G
Ref : Mol Metab , :101725 , 2023
PubMedID: 37059417
Gene_locus related to this paper: mouse-Ces2a

Title : The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1 - Eisner_2022_Int.J.Mol.Sci_23_13101
Author(s) : Eisner H , Riegler-Berket L , Gamez CFR , Sagmeister T , Chalhoub G , Darnhofer B , Jazleena PJ , Birner-Gruenberger R , Pavkov-Keller T , Haemmerle G , Schoiswohl G , Oberer M
Ref : Int J Mol Sci , 23 : , 2022
PubMedID: 36361897
Gene_locus related to this paper: mouse-Ces2c

Title : Hepatocyte-specific deletion of adipose triglyceride lipase (ATGL\/PNPLA2) ameliorates dietary induced steatohepatitis in mice - Fuchs_2021_Hepatology__
Author(s) : Fuchs CD , Radun R , Dixon ED , Mlitz V , Timelthaler G , Halilbasic E , Herac M , Jonker JW , Ronda O , Tardelli M , Haemmerle G , Zimmermann R , Scharnagl H , Stojakovic T , Verkade HJ , Trauner M
Ref : Hepatology , : , 2021
PubMedID: 34387896

Title : Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease - Chalhoub_2021_J.Lipid.Res__100075
Author(s) : Chalhoub G , Kolleritsch S , Maresch LK , Taschler U , Pajed L , Tilp A , Natmessnig H , Rosina P , Kien B , Radner FPW , Schicho R , Oberer M , Schoiswohl G , Haemmerle G
Ref : J Lipid Res , :100075 , 2021
PubMedID: 33872605
Gene_locus related to this paper: human-CES2 , mouse-Ces2a , mouse-Ces2b , mouse-Ces2c

Title : Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity - Maresch_2019_Hepatol.Commun_3_227
Author(s) : Maresch LK , Benedikt P , Feiler U , Eder S , Zierler KA , Taschler U , Kolleritsch S , Eichmann TO , Schoiswohl G , Leopold C , Wieser BI , Lackner C , Rulicke T , van Klinken J , Kratky D , Moustafa T , Hoefler G , Haemmerle G
Ref : Hepatol Commun , 3 :227 , 2019
PubMedID: 30766961
Gene_locus related to this paper: mouse-Ces2c

Title : The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4 - Jebessa_2019_Nat.Metab_1_1157
Author(s) : Jebessa ZH , Shanmukha Kumar D , Dewenter M , Lehmann LH , Xu C , Schreiter F , Siede D , Gong XM , Worst BC , Federico G , Sauer SW , Fischer T , Wechselberger L , Muller OJ , Sossalla S , Dieterich C , Most P , Grone HJ , Moro C , Oberer M , Haemmerle G , Katus HA , Tyedmers J , Backs J
Ref : Nat Metab , 1 :1157 , 2019
PubMedID: 31742248
Gene_locus related to this paper: human-ABHD5

Title : Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation - Leopold_2019_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1864_500
Author(s) : Leopold C , Duta-Mare M , Sachdev V , Goeritzer M , Maresch LK , Kolb D , Reicher H , Wagner B , Stojakovic T , Ruelicke T , Haemmerle G , Hoefler G , Sattler W , Kratky D
Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , 1864 :500 , 2019
PubMedID: 30639734
Gene_locus related to this paper: mouse-1llip

Title : ABHD5 stimulates PNPLA1-mediated omega-O-acylceramide biosynthesis essential for a functional skin permeability barrier - Kien_2018_J.Lipid.Res_59_2360
Author(s) : Kien B , Grond S , Haemmerle G , Lass A , Eichmann TO , Radner FPW
Ref : J Lipid Res , 59 :2360 , 2018
PubMedID: 30361410
Gene_locus related to this paper: human-ABHD5

Title : Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation - Grond_2017_J.Invest.Dermatol_137_403
Author(s) : Grond S , Radner FP , Eichmann TO , Kolb D , Grabner GF , Wolinski H , Gruber R , Hofer P , Heier C , Schauer S , Rulicke T , Hoefler G , Schmuth M , Elias PM , Lass A , Zechner R , Haemmerle G
Ref : Journal of Investigative Dermatology , 137 :403 , 2017
PubMedID: 27725204
Gene_locus related to this paper: human-ABHD5

Title : Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover - Grumet_2016_J.Biol.Chem_291_17977
Author(s) : Grumet L , Eichmann TO , Taschler U , Zierler KA , Leopold C , Moustafa T , Radovic B , Romauch M , Yan C , Du H , Haemmerle G , Zechner R , Fickert P , Kratky D , Zimmermann R , Lass A
Ref : Journal of Biological Chemistry , 291 :17977 , 2016
PubMedID: 27354281
Gene_locus related to this paper: human-LIPA , mouse-1llip

Title : Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation - Lord_2016_Cell.Rep_16_939
Author(s) : Lord CC , Ferguson D , Thomas G , Brown AL , Schugar RC , Burrows A , Gromovsky AD , Betters J , Neumann C , Sacks J , Marshall S , Watts R , Schweiger M , Lee RG , Crooke RM , Graham MJ , Lathia JD , Sakaguchi TF , Lehner R , Haemmerle G , Zechner R , Brown JM
Ref : Cell Rep , 16 :939 , 2016
PubMedID: 27396333

Title : Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity - Schreiber_2015_Proc.Natl.Acad.Sci.U.S.A_112_13850
Author(s) : Schreiber R , Hofer P , Taschler U , Voshol PJ , Rechberger GN , Kotzbeck P , Jaeger D , Preiss-Landl K , Lord CC , Brown JM , Haemmerle G , Zimmermann R , Vidal-Puig A , Zechner R
Ref : Proc Natl Acad Sci U S A , 112 :13850 , 2015
PubMedID: 26508640

Title : Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells - Taschler_2015_Biochim.Biophys.Acta_1851_937
Author(s) : Taschler U , Schreiber R , Chitraju C , Grabner GF , Romauch M , Wolinski H , Haemmerle G , Breinbauer R , Zechner R , Lass A , Zimmermann R
Ref : Biochimica & Biophysica Acta , 1851 :937 , 2015
PubMedID: 25732851

Title : Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling - Hofer_2015_J.Biol.Chem_290_18438
Author(s) : Hofer P , Boeszoermenyi A , Jaeger D , Feiler U , Arthanari H , Mayer N , Zehender F , Rechberger G , Oberer M , Zimmermann R , Lass A , Haemmerle G , Breinbauer R , Zechner R , Preiss-Landl K
Ref : Journal of Biological Chemistry , 290 :18438 , 2015
PubMedID: 25953897
Gene_locus related to this paper: human-ABHD5

Title : ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6 - Eichmann_2015_J.Lipid.Res_56_1972
Author(s) : Eichmann TO , Grumet L , Taschler U , Hartler J , Heier C , Woblistin A , Pajed L , Kollroser M , Rechberger G , Thallinger GG , Zechner R , Haemmerle G , Zimmermann R , Lass A
Ref : J Lipid Res , 56 :1972 , 2015
PubMedID: 26330055
Gene_locus related to this paper: human-ABHD5

Title : Comparative gene identification-58\/alpha\/beta hydrolase domain 5: more than just an adipose triglyceride lipase activator? - Zierler_2014_Curr.Opin.Lipidol_25_102
Author(s) : Zierler KA , Zechner R , Haemmerle G
Ref : Curr Opin Lipidol , 25 :102 , 2014
PubMedID: 24565921

Title : Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A - Nagy_2014_Biochim.Biophys.Acta_1841_588
Author(s) : Nagy HM , Paar M , Heier C , Moustafa T , Hofer P , Haemmerle G , Lass A , Zechner R , Oberer M , Zimmermann R
Ref : Biochimica & Biophysica Acta , 1841 :588 , 2014
PubMedID: 24440819

Title : Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation - Kienesberger_2013_Cardiovasc.Res_99_442
Author(s) : Kienesberger PC , Pulinilkunnil T , Nagendran J , Young ME , Bogner-Strauss JG , Hackl H , Khadour R , Heydari E , Haemmerle G , Zechner R , Kershaw EE , Dyck JR
Ref : Cardiovascular Research , 99 :442 , 2013
PubMedID: 23708736

Title : Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice - Fuchs_2012_Hepatology_56_270
Author(s) : Fuchs CD , Claudel T , Kumari P , Haemmerle G , Pollheimer MJ , Stojakovic T , Scharnagl H , Halilbasic E , Gumhold J , Silbert D , Koefeler H , Trauner M
Ref : Hepatology , 56 :270 , 2012
PubMedID: 22271167

Title : Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase - Kumari_2012_Cell.Metab_15_691
Author(s) : Kumari M , Schoiswohl G , Chitraju C , Paar M , Cornaciu I , Rangrez AY , Wongsiriroj N , Nagy HM , Ivanova PT , Scott SA , Knittelfelder O , Rechberger GN , Birner-Gruenberger R , Eder S , Brown HA , Haemmerle G , Oberer M , Lass A , Kershaw EE , Zimmermann R , Zechner R
Ref : Cell Metab , 15 :691 , 2012
PubMedID: 22560221

Title : Adipose Triglyceride Lipase (ATGL) and Hormone-Sensitive Lipase (HSL) Deficiencies Affect Expression of Lipolytic Activities in Mouse Adipose Tissues - Morak_2012_Mol.Cell.Proteomics_11_1777
Author(s) : Morak M , Schmidinger H , Riesenhuber G , Rechberger GN , Kollroser M , Haemmerle G , Zechner R , Kronenberg F , Hermetter A
Ref : Mol Cell Proteomics , 11 :1777 , 2012
PubMedID: 22984285

Title : Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARalpha agonist - Wolkart_2012_Br.J.Pharmacol_165_380
Author(s) : Wolkart G , Schrammel A , Dorffel K , Haemmerle G , Zechner R , Mayer B
Ref : British Journal of Pharmacology , 165 :380 , 2012
PubMedID: 21585347

Title : Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice - Obrowsky_2012_Biochim.Biophys.Acta_1821_1406
Author(s) : Obrowsky S , Chandak PG , Patankar JV , Pfeifer T , Povoden S , Schreiber R , Haemmerle G , Levak-Frank S , Kratky D
Ref : Biochimica & Biophysica Acta , 1821 :1406 , 2012
PubMedID: 22842588
Gene_locus related to this paper: mouse-hslip

Title : Adipose triglyceride lipase contributes to cancer-associated cachexia - Das_2011_Science_333_233
Author(s) : Das SK , Eder S , Schauer S , Diwoky C , Temmel H , Guertl B , Gorkiewicz G , Tamilarasan KP , Kumari P , Trauner M , Zimmermann R , Vesely P , Haemmerle G , Zechner R , Hoefler G
Ref : Science , 333 :233 , 2011
PubMedID: 21680814
Gene_locus related to this paper: human-LIPE

Title : Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice - Lammers_2011_Arterioscler.Thromb.Vasc.Biol_31_67
Author(s) : Lammers B , Chandak PG , Aflaki E , Van Puijvelde GH , Radovic B , Hildebrand RB , Meurs I , Out R , Kuiper J , van Berkel TJ , Kolb D , Haemmerle G , Zechner R , Levak-Frank S , Van Eck M , Kratky D
Ref : Arterioscler Thromb Vasc Biol , 31 :67 , 2011
PubMedID: 21030715

Title : Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase - Chandak_2010_J.Biol.Chem_285_20192
Author(s) : Chandak PG , Radovic B , Aflaki E , Kolb D , Buchebner M , Frohlich E , Magnes C , Sinner F , Haemmerle G , Zechner R , Tabas I , Levak-Frank S , Kratky D
Ref : Journal of Biological Chemistry , 285 :20192 , 2010
PubMedID: 20424161

Title : Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58) - Radner_2010_J.Biol.Chem_285_7300
Author(s) : Radner FP , Streith IE , Schoiswohl G , Schweiger M , Kumari M , Eichmann TO , Rechberger G , Koefeler HC , Eder S , Schauer S , Theussl HC , Preiss-Landl K , Lass A , Zimmermann R , Hoefler G , Zechner R , Haemmerle G
Ref : Journal of Biological Chemistry , 285 :7300 , 2010
PubMedID: 20023287
Gene_locus related to this paper: mouse-abhd5

Title : Cholesteryl ester hydrolase activity is abolished in HSL-\/- macrophages but unchanged in macrophages lacking KIAA1363 - Buchebner_2010_J.Lipid.Res_51_2896
Author(s) : Buchebner M , Pfeifer T , Rathke N , Chandak PG , Lass A , Schreiber R , Kratzer A , Zimmermann R , Sattler W , Koefeler H , Frohlich E , Kostner GM , Birner-Gruenberger R , Chiang KP , Haemmerle G , Zechner R , Levak-Frank S , Cravatt B , Kratky D
Ref : J Lipid Res , 51 :2896 , 2010
PubMedID: 20625037
Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1

Title : Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue - Kosteli_2010_J.Clin.Invest_120_3466
Author(s) : Kosteli A , Sugaru E , Haemmerle G , Martin JF , Lei J , Zechner R , Ferrante AW, Jr.
Ref : J Clinical Investigation , 120 :3466 , 2010
PubMedID: 20877011

Title : Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids - Schoiswohl_2010_J.Lipid.Res_51_490
Author(s) : Schoiswohl G , Schweiger M , Schreiber R , Gorkiewicz G , Preiss-Landl K , Taschler U , Zierler KA , Radner FP , Eichmann TO , Kienesberger PC , Eder S , Lass A , Haemmerle G , Alsted TJ , Kiens B , Hoefler G , Zechner R , Zimmermann R
Ref : J Lipid Res , 51 :490 , 2010
PubMedID: 19965578

Title : A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis - Fex_2009_Diabetologia_52_271
Author(s) : Fex M , Haemmerle G , Wierup N , Dekker-Nitert M , Rehn M , Ristow M , Zechner R , Sundler F , Holm C , Eliasson L , Mulder H
Ref : Diabetologia , 52 :271 , 2009
PubMedID: 19023560

Title : Fate of fat: the role of adipose triglyceride lipase in lipolysis - Zimmermann_2009_Biochim.Biophys.Acta_1791_494
Author(s) : Zimmermann R , Lass A , Haemmerle G , Zechner R
Ref : Biochimica & Biophysica Acta , 1791 :494 , 2009
PubMedID: 19010445

Title : Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores - Zechner_2009_J.Lipid.Res_50_3
Author(s) : Zechner R , Kienesberger PC , Haemmerle G , Zimmermann R , Lass A
Ref : J Lipid Res , 50 :3 , 2009
PubMedID: 18952573

Title : Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling - Kienesberger_2009_J.Biol.Chem_284_30218
Author(s) : Kienesberger PC , Lee D , Pulinilkunnil T , Brenner DS , Cai L , Magnes C , Koefeler HC , Streith IE , Rechberger GN , Haemmerle G , Flier JS , Zechner R , Kim YB , Kershaw EE
Ref : Journal of Biological Chemistry , 284 :30218 , 2009
PubMedID: 19723629

Title : Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion - Peyot_2009_J.Biol.Chem_284_16848
Author(s) : Peyot ML , Guay C , Latour MG , Lamontagne J , Lussier R , Pineda M , Ruderman NB , Haemmerle G , Zechner R , Joly E , Madiraju SR , Poitout V , Prentki M
Ref : Journal of Biological Chemistry , 284 :16848 , 2009
PubMedID: 19389712

Title : The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding - Schweiger_2008_J.Biol.Chem_283_17211
Author(s) : Schweiger M , Schoiswohl G , Lass A , Radner FP , Haemmerle G , Malli R , Graier W , Cornaciu I , Oberer M , Salvayre R , Fischer J , Zechner R , Zimmermann R
Ref : Journal of Biological Chemistry , 283 :17211 , 2008
PubMedID: 18445597

Title : Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome - Lass_2006_Cell.Metab_3_309
Author(s) : Lass A , Zimmermann R , Haemmerle G , Riederer M , Schoiswohl G , Schweiger M , Kienesberger P , Strauss JG , Gorkiewicz G , Zechner R
Ref : Cell Metab , 3 :309 , 2006
PubMedID: 16679289
Gene_locus related to this paper: human-ABHD5

Title : Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism - Schweiger_2006_J.Biol.Chem_281_40236
Author(s) : Schweiger M , Schreiber R , Haemmerle G , Lass A , Fledelius C , Jacobsen P , Tornqvist H , Zechner R , Zimmermann R
Ref : Journal of Biological Chemistry , 281 :40236 , 2006
PubMedID: 17074755

Title : Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase - Haemmerle_2006_Science_312_734
Author(s) : Haemmerle G , Lass A , Zimmermann R , Gorkiewicz G , Meyer C , Rozman J , Heldmaier G , Maier R , Theussl C , Eder S , Kratky D , Wagner EF , Klingenspor M , Hoefler G , Zechner R
Ref : Science , 312 :734 , 2006
PubMedID: 16675698

Title : The lipolytic proteome of mouse adipose tissue - Birner-Gruenberger_2005_Mol.Cell.Proteomics_4_1710
Author(s) : Birner-Gruenberger R , Susani-Etzerodt H , Waldhuber M , Riesenhuber G , Schmidinger H , Rechberger G , Kollroser M , Strauss JG , Lass A , Zimmermann R , Haemmerle G , Zechner R , Hermetter A
Ref : Mol Cell Proteomics , 4 :1710 , 2005
PubMedID: 16048907

Title : Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue - Kratky_2005_J.Clin.Invest_115_161
Author(s) : Kratky D , Zimmermann R , Wagner EM , Strauss JG , Jin W , Kostner GM , Haemmerle G , Rader DJ , Zechner R
Ref : J Clinical Investigation , 115 :161 , 2005
PubMedID: 15630456

Title : Lipolysis: pathway under construction - Zechner_2005_Curr.Opin.Lipidol_16_333
Author(s) : Zechner R , Strauss JG , Haemmerle G , Lass A , Zimmermann R
Ref : Curr Opin Lipidol , 16 :333 , 2005
PubMedID: 15891395

Title : Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression - Augustus_2004_J.Biol.Chem_279_25050
Author(s) : Augustus A , Yagyu H , Haemmerle G , Bensadoun A , Vikramadithyan RK , Park SY , Kim JK , Zechner R , Goldberg IJ
Ref : Journal of Biological Chemistry , 279 :25050 , 2004
PubMedID: 15028738

Title : Letting lipids go: hormone-sensitive lipase - Haemmerle_2003_Curr.Opin.Lipidol_14_289
Author(s) : Haemmerle G , Zimmermann R , Zechner R
Ref : Curr Opin Lipidol , 14 :289 , 2003
PubMedID: 12840660

Title : Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice - Voshol_2003_Endocrinology_144_3456
Author(s) : Voshol PJ , Haemmerle G , Ouwens DM , Zimmermann R , Zechner R , Teusink B , Maassen JA , Havekes LM , Romijn JA
Ref : Endocrinology , 144 :3456 , 2003
PubMedID: 12865325
Gene_locus related to this paper: mouse-hslip

Title : Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle - Haemmerle_2002_J.Biol.Chem_277_12946
Author(s) : Haemmerle G , Zimmermann R , Strauss JG , Kratky D , Riederer M , Knipping G , Zechner R
Ref : Journal of Biological Chemistry , 277 :12946 , 2002
PubMedID: 11809748