Gene_locus Report for: clals-a0a202gac7 Clavispora lusitaniae (Candida lusitaniae). Putative histone deacetylase
Comment
Other strains: Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae). Uncharacterized protein Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Saccharomycotina: N E > Saccharomycetes: N E > Saccharomycetales: N E > Metschnikowiaceae: N E > Clavispora: N E > Clavispora lusitaniae: N E 6_AlphaBeta_hydrolase :
clal4-c4y5j9 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein .
A85-EsteraseD-FGH :
clal4-c4xzz1 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein .
ABHD11-Acetyl_transferase :
clal4-c4y8j2 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae). Uncharacterized protein .
abh_upf0017 :
clal4-c4y4w8 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein .
Acidic_Lipase :
clal4-c4y4f2 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein ,
clal4-c4y5j4 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein .
Carboxypeptidase_S10 :
clal4-kex1 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae). Carboxypeptidase D .
CGI-58_ABHD5_ABHD4 :
clal4-c4y7z7 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein ,
clal4-c4y035 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein ,
clal4-c4y898 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein ,
clal4-c4yas2 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein .
DPP4N_Peptidase_S9 :
clal4-c4y3e1 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein ,
clal4-c4y481 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candid lusitaniae) Putative uncharacterized protein .
Duf_726 :
clal4-c4y8q1 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein .
Epoxide_hydrolase :
clal4-c4xyx9 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein .
Fusarinine_C_esterase_sidJ :
clal4-c4xwy4 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein .
Kynurenine-formamidase :
clal4-c4y0l0 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae). N-formylkynurenine formamidase .
LIDHydrolase :
clal4-c4xvt8 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein .
Monoglyceridelipase_lysophospholip :
clal4-c4yc85 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein .
PPase_methylesterase_euk :
clal4-c4y538 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Protein phosphatase methylesterase 1 .
Proline_iminopeptidase :
clal4-c4y5a2 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae). Putative uncharacterized protein .
Steryl_acetyl_hydrolase :
clal4-c4xy03 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein ,
clal4-c4yba6 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein ,
clal4-c4yba7 Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can
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(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Clavispora lusitaniae ATCC 42720:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: clals-a0a202gac7 Colored MSA for Arb2_domain (raw)
LAEPVRAHQAAELFARHGFVPLPVLPDGFSEMPPHADELVLASPDIADCP
TVMVCVHDPPEVWADVNAVSGTIESGSSVILEHPLARIMARMSAESDEKI
GYIDICIPEGYGVFAQELLLWVWDNYVSYFSAKKALFVGYGDAHQAVVHL
LAKRPANELREVVRASVAFVNASPLKPLVPVMDESMVDWYYQNSLIFASR
TNACWAGAKDEDKRPRKKFGRVLKAAGDGLWEVIHERFDEGVDFLLDSVG
DFSDSE
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
L A E P V R A H Q A A E L F A R H G F V P L P V L P D G F S E M P P H A D E L V L A S P D I A D C P T V M V C V H D P P E V W A D V N A V S G T I E S G S S V I L E H P L A R I M A R M S A E S D E K I G Y I D I C I P E G Y G V F A Q E L L L W V W D N Y V S Y F S A K K A L F V G Y G D A H Q A V V H L L A K R P A N E L R E V V R A S V A F V N A S P L K P L V P V M D E S M V D W Y Y Q N S L I F A S R T N A C W A G A K D E D K R P R K K F G R V L K A A G D G L W E V I H E R F D E G V D F L L D S V G D F S D S E
Reference
Title: Evolution of pathogenicity and sexual reproduction in eight Candida genomesButler G , Rasmussen MD , Lin MF , Santos MA , Sakthikumar S , Munro CA , Rheinbay E , Grabherr M , Forche A and Cuomo CA <41 more author(s)> Butler G , Rasmussen MD , Lin MF , Santos MA , Sakthikumar S , Munro CA , Rheinbay E , Grabherr M , Forche A , Reedy JL , Agrafioti I , Arnaud MB , Bates S , Brown AJ , Brunke S , Costanzo MC , Fitzpatrick DA , de Groot PW , Harris D , Hoyer LL , Hube B , Klis FM , Kodira C , Lennard N , Logue ME , Martin R , Neiman AM , Nikolaou E , Quail MA , Quinn J , Santos MC , Schmitzberger FF , Sherlock G , Shah P , Silverstein KA , Skrzypek MS , Soll D , Staggs R , Stansfield I , Stumpf MP , Sudbery PE , Srikantha T , Zeng Q , Berman J , Berriman M , Heitman J , Gow NA , Lorenz MC , Birren BW , Kellis M , Cuomo CA (- 41) Ref: Nature, 459 :657, 2009 : PubMed Abstract ESTHER: Butler_2009_Nature_459_657 PubMedSearch: Butler 2009 Nature 459 657 PubMedID: 19465905 Gene_locus related to this paper: canal-ATG15 ,
canal-bna7 ,
canal-c4yl13 ,
canal-LIP1 ,
canal-LIP2 ,
canal-LIP3 ,
canal-LIP4 ,
canal-LIP5 ,
canal-LIP6 ,
canal-LIP7 ,
canal-LIP8 ,
canal-LIP9 ,
canal-LIP10 ,
canal-ppme1 ,
canal-q5a0c9 ,
canal-q5a2i9 ,
canal-q5a042 ,
canal-q5ad17 ,
canal-q5aeu3 ,
canal-q5afp8 ,
canal-q5ag57 ,
canal-q5ai09 ,
canal-q5ai12 ,
canal-q5ajt3 ,
canal-q5akz5 ,
canal-q5apu4 ,
canal-q59l46 ,
canal-q59m48 ,
canal-q59nw6 ,
canal-q59u61 ,
canal-q59u64 ,
canal-q59vp0 ,
canal-q59y97 ,
canaw-c4ykb1 ,
canaw-c4yrn6 ,
canaw-c4yrn9 ,
canaw-c4yrr3 ,
canaw-c4yrv3 ,
canaw-c4ys26 ,
cantt-c5m3d7 ,
cantt-c5m3y5 ,
cantt-c5m4x0 ,
cantt-c5m5e8 ,
cantt-c5m5w2 ,
cantt-c5m8s7 ,
cantt-c5m9c2 ,
cantt-c5m465 ,
cantt-c5m751 ,
cantt-c5m793 ,
cantt-c5m893 ,
cantt-c5ma78 ,
cantt-c5mag0 ,
cantt-c5mbb8 ,
cantt-c5mc53 ,
cantt-c5md87 ,
cantt-c5mdy3 ,
cantt-c5mey7 ,
cantt-c5mfg0 ,
cantt-c5mfh8 ,
cantt-c5mg56 ,
cantt-c5mgj0 ,
cantt-c5mh75 ,
cantt-c5mh80 ,
cantt-c5mh89 ,
cantt-c5mhh0 ,
cantt-c5mhn5 ,
cantt-c5mij5 ,
cantt-c5min7 ,
clal4-c4xvt8 ,
clal4-c4xwy4 ,
clal4-c4xy03 ,
clal4-c4xyx9 ,
clal4-c4xzz1 ,
clal4-c4y3e1 ,
clal4-c4y4f2 ,
clal4-c4y4w8 ,
clal4-c4y5j4 ,
clal4-c4y5j9 ,
clal4-c4y7z7 ,
clal4-c4y8q1 ,
clal4-c4y035 ,
clal4-c4y481 ,
clal4-c4y538 ,
clal4-c4y898 ,
clal4-c4yas2 ,
clal4-c4yba6 ,
clal4-c4yba7 ,
clal4-c4yc85 ,
lodel-a5drz3 ,
lodel-a5ds97 ,
lodel-a5dsc0 ,
lodel-a5duu4 ,
lodel-a5duy7 ,
lodel-a5dv03 ,
lodel-a5dv46 ,
lodel-a5dw16 ,
lodel-a5dwv7 ,
lodel-a5dww6 ,
lodel-a5dxf3 ,
lodel-a5e0z5 ,
lodel-a5e1c1 ,
lodel-a5e1l4 ,
lodel-a5e1p3 ,
lodel-a5e2s1 ,
lodel-a5e2t8 ,
lodel-a5e2v2 ,
lodel-a5e4u8 ,
lodel-a5e5a9 ,
lodel-a5e5k1 ,
lodel-a5e5z7 ,
lodel-a5e6w1 ,
lodel-a5e028 ,
lodel-atg15 ,
lodel-kex1 ,
picgu-a5d9u2 ,
picgu-a5dav0 ,
picgu-a5dbk0 ,
picgu-a5dc45 ,
picgu-a5dc73 ,
picgu-a5dc74 ,
picgu-a5dc75 ,
picgu-a5ddt8 ,
picgu-a5dev7 ,
picgu-a5dh90 ,
picgu-a5dhe3 ,
picgu-a5di38 ,
picgu-a5dj06 ,
picgu-a5dkd8 ,
picgu-a5dle9 ,
picgu-a5dlj5 ,
picgu-a5dm19 ,
picgu-a5dn92 ,
picgu-a5dnr3 ,
picgu-a5dnt6 ,
picgu-a5dqu5 ,
picgu-a5dr14 ,
picgu-a5drl3 ,
picgu-atg15 ,
picgu-bna7 ,
picgu-a5d9q3 ,
picgu-a5dag9 ,
clal4-c4y5a2 ,
clal4-c4y0l0 ,
cantt-c5mcb1 ,
clal4-c4y8j2 ,
cantt-c5m494 ,
clals-a0a202gac7 ,
canal-hda1 ,
picgu-a5dks8 ,
lodel-a5drs6 ,
canpc-g8bbk1 ,
cantt-kex1 ,
clal4-kex1 ,
picgu-kex1 Abstract
Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
Other Papers
