CID155803792
ABHD17B IC50 0.25(0.19-0.32) microM ; LYPLA1 IC50 0.11(0.72-0.17) microM
General
Type : Piperazine, Trifluoro, Sulfur Compound, Sulfonamide, Morpholine, Pyrazole
Chemical_Nomenclature : N,N-dimethyl-1-[4-[[2-morpholin-4-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbonyl]pyrazole-3-sulfonamide
Canonical SMILES : CN(C)S(=O)(=O)C1=NN(C=C1)C(=O)N2CCN(CC2)CC3=C(C=C(C=C3)C(F)(F)F)N4CCOCC4
InChI : InChI=1S\/C22H29F3N6O4S\/c1-27(2)36(33,34)20-5-6-31(26-20)21(32)30-9-7-28(8-10-30)16-17-3-4-18(22(23,24)25)15-19(17)29-11-13-35-14-12-29\/h3-6,15H,7-14,16H2,1-2H3
InChIKey : SITGALGMKCIASL-UHFFFAOYSA-N
Other name(s) : Compound 3 Remsberg et al.
MW : 530.6
Formula : C22H29F3N6O4S
CAS_number :
PubChem : 155803792
UniChem : SITGALGMKCIASL-UHFFFAOYSA-N
Target
Families : CID155803792 ligand of proteins in family
ABHD17-depalmitoylase
LYsophospholipase_carboxylesterase
Protein :
human-ABHD17B
human-LYPLA1
References (1)
| Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__ |
| Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF |
| Ref : Nat Chemical Biology , : , 2021 |
| Abstract : |
| PubMedSearch : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedID: 33927411 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |