Carbacrine

IC50 AChE 0.00215 microM BChE 0.296 microM

General

Type : Alkyl linked bis-ligand, Multitarget, Carbazol, Derivative of Tacrine, NMDA-Ligand

Chemical_Nomenclature : || N-[3-(9H-carbazol-4-yloxy)propyl]-N'-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)propane-1,3-diamine

Canonical SMILES : C1CCC2=NC3=C(C=CC(=C3)Cl)C(=C2C1)NCCCNCCCOC4=CC=CC5=C4C6=CC=CC=C6N5

InChI : InChI=1S\/C31H33ClN4O\/c32-21-14-15-24-28(20-21)36-26-11-4-2-9-23(26)31(24)34-18-6-16-33-17-7-19-37-29-13-5-12-27-30(29)22-8-1-3-10-25(22)35-27\/h1,3,5,8,10,12-15,20,33,35H,2,4,6-7,9,11,16-19H2,(H,34,36)

InChIKey : LPEKEPLZQKHSPL-UHFFFAOYSA-N

Other name(s) : CHEMBL478666  ||  BDBM50263213


MW : 513.1

Formula : C31H33ClN4O

CAS_number :

PubChem : 24949376

UniChem : LPEKEPLZQKHSPL-UHFFFAOYSA-N

Target

Families : Carbacrine ligand of proteins in family
BCHE ACHE

References (2)

Title : MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond - Bolognesi_2009_Curr.Pharm.Des_15_601
Author(s) : Bolognesi ML , Rosini M , Andrisano V , Bartolini M , Minarini A , Tumiatti V , Melchiorre C
Ref : Curr Pharm Des , 15 :601 , 2009
Abstract :
PubMedSearch : Bolognesi_2009_Curr.Pharm.Des_15_601
PubMedID: 19199985

Title : Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush - Rosini_2008_J.Med.Chem_51_4381
Author(s) : Rosini M , Simoni E , Bartolini M , Cavalli A , Ceccarini L , Pascu N , McClymont DW , Tarozzi A , Bolognesi ML , Minarini A , Tumiatti V , Andrisano V , Mellor IR , Melchiorre C
Ref : Journal of Medicinal Chemistry , 51 :4381 , 2008
Abstract :
PubMedSearch : Rosini_2008_J.Med.Chem_51_4381
PubMedID: 18605718