KT109
KT109 and KT172 are Specific DAGLB inhibitors. However inhibits also ABHD6 and CES1 (Iglesias 2016)
General
Type : Piperidine, Biphenyl, Triazol
Chemical_Nomenclature : (2-benzylpiperidin-1-yl)-[4-(4-phenylphenyl)triazol-1-yl]methanone
Canonical SMILES : C1CCN(C(C1)CC2=CC=CC=C2)C(=O)N3C=C(N=N3)C4=CC=C(C=C4)C5=CC=CC=C5
InChI : InChI=1S\/C27H26N4O\/c32-27(30-18-8-7-13-25(30)19-21-9-3-1-4-10-21)31-20-26(28-29-31)24-16-14-23(15-17-24)22-11-5-2-6-12-22\/h1-6,9-12,14-17,20,25H,7-8,13,18-19H2
InChIKey : JKJMWHULJIOKPJ-UHFFFAOYSA-N
Other name(s) : (4-([1,1'-Biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-benzylpiperidin-1-yl)methanone || MLS004256813 || CHEMBL2144065 || SCHEMBL13192827 || AOB3993
MW : 422.52
Formula : C27H26N4O
CAS_number : 1402612-55-8
PubChem : 53364540
UniChem : JKJMWHULJIOKPJ-UHFFFAOYSA-N
Target
Families : KT109 ligand of proteins in family
Lipase_3
Carb_B_Chordata
ABHD6-Lip
abh_upf0017
Protein :
human-DAGLB
human-ABHD2
References (5)
| Title : ABHD2 activity is not required for the non-genomic action of progesterone on human sperm - Arnolds_2025_Biorxiv__ |
| Author(s) : Arnolds O , Carter EM , Edwards M , Wigren E , Homan E , Ribera P , Bentley K , Haraldsson M , Theo-Emegano N , Loppnau P , Szewczyk MM , Cao MA , Barsyte-Lovejoy D , Vester K , Thrun A , Amaral A , Lesche R , Munchow J , Zhu WF , Temme L , Brenker C , Strunker T , Sundstrom M , Todd MH , Edwards AM , Tredup C , Gileadi O |
| Ref : Biorxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Arnolds_2025_Biorxiv__ |
| PubMedID: |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Inhibition of DAGLbeta as a therapeutic target for pain in sickle cell disease - Khasabova_2022_Haematologica__ |
| Author(s) : Khasabova IA , Gable J , Johns M , Khasabov SG , Kalyuzhny AE , Golovko MY , Golovko SA , Kiven S , Gupta K , Seybold VS , Simone DA |
| Ref : Haematologica , : , 2022 |
| Abstract : |
| PubMedSearch : Khasabova_2022_Haematologica__ |
| PubMedID: 35615929 |
| Gene_locus related to this paper: human-DAGLB |
| Title : Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors - Iglesias_2016_J.Lipid.Res_57_131 |
| Author(s) : Iglesias J , Lamontagne J , Erb H , Gezzar S , Zhao S , Joly E , Truong VL , Skorey K , Crane S , Madiraju SR , Prentki M |
| Ref : J Lipid Res , 57 :131 , 2016 |
| Abstract : |
| PubMedSearch : Iglesias_2016_J.Lipid.Res_57_131 |
| PubMedID: 26423520 |
| Title : Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis - Hsu_2013_J.Med.Chem_56_8257 |
| Author(s) : Hsu KL , Tsuboi K , Whitby LR , Speers AE , Pugh H , Inloes J , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 56 :8257 , 2013 |
| Abstract : |
| PubMedSearch : Hsu_2013_J.Med.Chem_56_8257 |
| PubMedID: 24152245 |
| Gene_locus related to this paper: human-DAGLB |
| Title : DAGLbeta inhibition perturbs a lipid network involved in macrophage inflammatory responses - Hsu_2012_Nat.Chem.Biol_8_999 |
| Author(s) : Hsu KL , Tsuboi K , Adibekian A , Pugh H , Masuda K , Cravatt BF |
| Ref : Nat Chemical Biology , 8 :999 , 2012 |
| Abstract : |
| PubMedSearch : Hsu_2012_Nat.Chem.Biol_8_999 |
| PubMedID: 23103940 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |