SCHEMBL31371543
Dual Butyrylcholinesterase and p38 Mitogen-Activated Protein Kinase Inhibitor. IC50 hBChE 0.652 +/- 0.112 microM; IC50 p38alpha MAPK 0.377 +/- 0.123 microM; residual activity at 100 microM AChE 69 +/- 4 %
General
Type : Multitarget, Carboxamide, Indazole, p38-MAPK-inhibitor
Chemical_Nomenclature : 5-[(2,4-difluorophenyl)methyl]-N-[2-(dimethylamino)ethyl]-1-(2-methylpropyl)indazole-6-carboxamide
Canonical SMILES : CC(C)CN1C2=CC(=C(C=C2C=N1)CC3=C(C=C(C=C3)F)F)C(=O)NCCN(C)C
InChI : InChI=1S\/C23H28F2N4O\/c1-15(2)14-29-22-12-20(23(30)26-7-8-28(3)4)17(10-18(22)13-27-29)9-16-5-6-19(24)11-21(16)25\/h5-6,10-13,15H,7-9,14H2,1-4H3,(H,26,30)
InChIKey : TUBNXZBDPQKQDZ-UHFFFAOYSA-N
Other name(s) : 5-(2,4-Difluorobenzyl)-N-(2-(dimethylamino)ethyl)-1-isobutyl-1H-indazole-6-carboxamide (94) || Compound 94 || A1A2O
MW : 414.5
Formula : C23H28F2N4O
CAS_number :
PubChem : 176205064
UniChem : TUBNXZBDPQKQDZ-UHFFFAOYSA-N
Target
References (1)
| Title : Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38alpha Mitogen-Activated Protein Kinase Inhibitors - Ferjancic Benetik_2025_J.Med.Chem__ |
| Author(s) : Ferjancic Benetik S , Proj M , Knez D , Kosak U , Meden A , Krajsek K , Pislar A , Horvat S , Svajger U , Tesic N , Pulkrabkova L , Soukup O , Skarka A , Andrys R , Brazzolotto X , Igert A , Nachon F , Dias J , Detka J , Gdula-Argasinska J , Wyska E , Szafarz M , Manik A , Plachtij N , Musilek K , Salat K , Obreza A , Gobec S |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Ferjancic Benetik_2025_J.Med.Chem__ |
| PubMedID: 40779804 |