WWL222
inhibitor of human-ABHD11 IC50 = 170 nM
General
Type : pNP, Carbamate, Piperidine
Chemical_Nomenclature : (4-nitrophenyl) 2-ethylpiperidine-1-carboxylate
Canonical SMILES : CCC1CCCCN1C(=O)OC2=CC=C(C=C2)[N+](=O)[O-]
InChI : InChI=1S\/C14H18N2O4\/c1-2-11-5-3-4-10-15(11)14(17)20-13-8-6-12(7-9-13)16(18)19\/h6-9,11H,2-5,10H2,1H3
InChIKey : QXUOQNPHJZFAKP-UHFFFAOYSA-N
Other name(s) : Compound 47 || Compound-47 || SR-02000001277 || SR-02000001277-1 || 4-nitrophenyl 2-ethylpiperidine-1-carboxylate
MW : 278.30
Formula : C14H18N2O4
CAS_number :
PubChem : 53234165
UniChem : QXUOQNPHJZFAKP-UHFFFAOYSA-N
Target
Families : WWL222 ligand of proteins in family
ABHD11-Acetyl_transferase
Protein :
human-ABHD11
References (9)
| Title : ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity - Jenkins_2025_bioRxiv__ |
| Author(s) : Jenkins BJ , Jenkins YR , Ponce-Garcia FM , Moscrop C , Perry IA , Hitchings MD , Uribe AH , Bernuzzi F , Eastham S , Cronin JG , Berisha A , Howell A , Davies J , Blagih J , Veale DJ , Davies LC , Niphakis M , Finlay DK , Sinclair LV , Cravatt BF , Hogan AE , Nathan JA , Fearon U , Sumpton D , Vande Voorde J , Dias do Vale G , McDonald JG , Jones GW , Pearson JA , Vincent EE , Jones N |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Jenkins_2025_bioRxiv__ |
| PubMedID: 40166327 |
| Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11 |
| Title : Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Jenkins_2025_Nat.Commun_16_9484 |
| Author(s) : Jenkins BJ , Jenkins YR , Ponce-Garcia FM , Moscrop C , Perry IA , Hitchings MD , Uribe AH , Bernuzzi F , Eastham S , Cronin JG , Berisha A , Howell A , Davies J , Blagih J , Williams M , Marsden M , Veale DJ , Davies LC , Niphakis M , Finlay DK , Sinclair LV , Cravatt BF , Hogan AE , Nathan JA , Humphreys IR , Fearon U , Sumpton D , Vande Voorde J , Vale GDD , McDonald JG , Jones GW , Pearson JA , Vincent EE , Jones N |
| Ref : Nat Commun , 16 :9484 , 2025 |
| Abstract : |
| PubMedSearch : Jenkins_2025_Nat.Commun_16_9484 |
| PubMedID: 41184294 |
| Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11 |
| Title : ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity - Jenkins_2025_bioRxiv__ |
| Author(s) : Jenkins BJ , Jenkins YR , Ponce-Garcia FM , Moscrop C , Perry IA , Hitchings MD , Uribe AH , Bernuzzi F , Eastham S , Cronin JG , Berisha A , Howell A , Davies J , Blagih J , Veale DJ , Davies LC , Niphakis M , Finlay DK , Sinclair LV , Cravatt BF , Hogan AE , Nathan JA , Fearon U , Sumpton D , Vande Voorde J , Dias do Vale G , McDonald JG , Jones GW , Pearson JA , Vincent EE , Jones N |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Jenkins_2025_bioRxiv__ |
| PubMedID: 40166327 |
| Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11 |
| Title : Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Jenkins_2025_Nat.Commun_16_9484 |
| Author(s) : Jenkins BJ , Jenkins YR , Ponce-Garcia FM , Moscrop C , Perry IA , Hitchings MD , Uribe AH , Bernuzzi F , Eastham S , Cronin JG , Berisha A , Howell A , Davies J , Blagih J , Williams M , Marsden M , Veale DJ , Davies LC , Niphakis M , Finlay DK , Sinclair LV , Cravatt BF , Hogan AE , Nathan JA , Humphreys IR , Fearon U , Sumpton D , Vande Voorde J , Vale GDD , McDonald JG , Jones GW , Pearson JA , Vincent EE , Jones N |
| Ref : Nat Commun , 16 :9484 , 2025 |
| Abstract : |
| PubMedSearch : Jenkins_2025_Nat.Commun_16_9484 |
| PubMedID: 41184294 |
| Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11 |
| Title : ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity - Jenkins_2025_bioRxiv__ |
| Author(s) : Jenkins BJ , Jenkins YR , Ponce-Garcia FM , Moscrop C , Perry IA , Hitchings MD , Uribe AH , Bernuzzi F , Eastham S , Cronin JG , Berisha A , Howell A , Davies J , Blagih J , Veale DJ , Davies LC , Niphakis M , Finlay DK , Sinclair LV , Cravatt BF , Hogan AE , Nathan JA , Fearon U , Sumpton D , Vande Voorde J , Dias do Vale G , McDonald JG , Jones GW , Pearson JA , Vincent EE , Jones N |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Jenkins_2025_bioRxiv__ |
| PubMedID: 40166327 |
| Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11 |
| Title : Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Jenkins_2025_Nat.Commun_16_9484 |
| Author(s) : Jenkins BJ , Jenkins YR , Ponce-Garcia FM , Moscrop C , Perry IA , Hitchings MD , Uribe AH , Bernuzzi F , Eastham S , Cronin JG , Berisha A , Howell A , Davies J , Blagih J , Williams M , Marsden M , Veale DJ , Davies LC , Niphakis M , Finlay DK , Sinclair LV , Cravatt BF , Hogan AE , Nathan JA , Humphreys IR , Fearon U , Sumpton D , Vande Voorde J , Vale GDD , McDonald JG , Jones GW , Pearson JA , Vincent EE , Jones N |
| Ref : Nat Commun , 16 :9484 , 2025 |
| Abstract : |
| PubMedSearch : Jenkins_2025_Nat.Commun_16_9484 |
| PubMedID: 41184294 |
| Gene_locus related to this paper: human-ABHD11 , mouse-Abhd11 |
| Title : Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening - Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| Author(s) : Bachovchin DA , Ji T , Li W , Simon GM , Blankman JL , Adibekian A , Hoover H , Niessen S , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 107 :20941 , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| PubMedID: 21084632 |
| Title : Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening - Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| Author(s) : Bachovchin DA , Ji T , Li W , Simon GM , Blankman JL , Adibekian A , Hoover H , Niessen S , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 107 :20941 , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| PubMedID: 21084632 |
| Title : Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening - Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| Author(s) : Bachovchin DA , Ji T , Li W , Simon GM , Blankman JL , Adibekian A , Hoover H , Niessen S , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 107 :20941 , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| PubMedID: 21084632 |