WWL229
General
Type : pNP, Carbamate, Piperidine
Chemical_Nomenclature : (4-nitrophenyl) 2-(3-methoxypropyl)piperidine-1-carboxylate
Canonical SMILES : COCCCC1CCCCN1C(=O)OC2=CC=C(C=C2)[N+](=O)[O-]
InChI : InChI=1S\/C16H22N2O5\/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21\/h7-10,13H,2-6,11-12H2,1H3
InChIKey : XVBRVSAGMWRVCK-UHFFFAOYSA-N
Other name(s) : Wwl229 || WWL-229 || 4-Nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate || AOB2408 || SYN5249 || MolPort-039-138-796 || HY-120602
MW : 322.36
Formula : C16H22N2O5
CAS_number : 1338575-28-2
PubChem : 72183487
UniChem : XVBRVSAGMWRVCK-UHFFFAOYSA-N
Target
Families : WWL229 ligand of proteins in family
Carb_B_Chordata
Protein :
human-CES3
mouse-Ces1d
human-CES1
References (6)
| Title : Thromboxane A2 synthase is an off target of the CES1 small-molecule inhibitor WWL113 - Borazjani_2026_Prostaglandins.Other.Lipid.Mediat_184_107074 |
| Author(s) : Borazjani A , Odom K , Oluwabori A , Ross MK |
| Ref : Prostaglandins Other Lipid Mediat , 184 :107074 , 2026 |
| Abstract : |
| PubMedSearch : Borazjani_2026_Prostaglandins.Other.Lipid.Mediat_184_107074 |
| PubMedID: 41935416 |
| Title : Carboxylesterase 1d-mediated aglycone recognition is crucial for substrate processing and allosteric activation of endo-alpha-mannosidase in the endoplasmic reticulum - Taira_2026_Bioorg.Med.Chem_134_118547 |
| Author(s) : Taira A , Kuribara T , Hirose M , Totani K |
| Ref : Bioorganic & Medicinal Chemistry , 134 :118547 , 2026 |
| Abstract : |
| PubMedSearch : Taira_2026_Bioorg.Med.Chem_134_118547 |
| PubMedID: 41505878 |
| Gene_locus related to this paper: mouse-Ces1d |
| Title : Carboxylesterase 1d Inactivation Augments Lung Inflammation in Mice - Szafran_2022_ACS.Pharmacol.Transl.Sci_5_919 |
| Author(s) : Szafran BN , Borazjani A , Scheaffer HL , Crow JA , McBride AM , Adekanye O , Wonnacott CB , Lehner R , Kaplan BLF , Ross MK |
| Ref : ACS Pharmacol Transl Sci , 5 :919 , 2022 |
| Abstract : |
| PubMedSearch : Szafran_2022_ACS.Pharmacol.Transl.Sci_5_919 |
| PubMedID: 36268116 |
| Title : Inactivation of CES1 Blocks Prostaglandin D(2) Glyceryl Ester Catabolism in Monocytes\/Macrophages and Enhances Its Anti-inflammatory Effects, Whereas the Pro-inflammatory Effects of Prostaglandin E(2) Glyceryl Ester Are Attenuated - Scheaffer_2020_ACS.Omega_5_29177 |
| Author(s) : Scheaffer HL , Borazjani A , Szafran BN , Ross MK |
| Ref : ACS Omega , 5 :29177 , 2020 |
| Abstract : |
| PubMedSearch : Scheaffer_2020_ACS.Omega_5_29177 |
| PubMedID: 33225149 |
| Gene_locus related to this paper: human-CES1 |
| Title : A Unique Role of Carboxylesterase 3 (Ces3) in beta-Adrenergic Signaling-Stimulated Thermogenesis - Yang_2019_Diabetes_68_1178 |
| Author(s) : Yang L , Li X , Tang H , Gao Z , Zhang K , Sun K |
| Ref : Diabetes , 68 :1178 , 2019 |
| Abstract : |
| PubMedSearch : Yang_2019_Diabetes_68_1178 |
| PubMedID: 30862682 |
| Gene_locus related to this paper: human-CES3 , mouse-Ces1d |
| Title : Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes - Dominguez_2014_Nat.Chem.Biol_10_113 |
| Author(s) : Dominguez E , Galmozzi A , Chang JW , Hsu KL , Pawlak J , Li W , Godio C , Thomas J , Partida D , Niessen S , O'Brien PE , Russell AP , Watt MJ , Nomura DK , Cravatt BF , Saez E |
| Ref : Nat Chemical Biology , 10 :113 , 2014 |
| Abstract : |
| PubMedSearch : Dominguez_2014_Nat.Chem.Biol_10_113 |
| PubMedID: 24362705 |
| Gene_locus related to this paper: human-CES3 , mouse-Ces1d |