7AIY
Name : Crystal structure of human butyrylcholinesterase in complex with 2-{1-[4-(12-Amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolin-9-yl)butyl]-1H-1,2,3-triazol-4-yl}-N-[4-hydroxy-3-methoxybenzyl]acetamide compound 5i
Revelation date : 06-Oct-2021
Family : BCHE
Gene_locus : human-BCHE
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Coquelle, N.,Colletier, J.P.
Ligand : Inhibitor 8U2-7AIX7AY-compound5i Ligand in structure: Ligplot
References (1)
| Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812 |
| Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 64 :812 , 2021 |
| Abstract : |
| PubMedSearch : Viayna_2021_J.Med.Chem_64_812 |
| PubMedID: 33356266 |
| Gene_locus related to this paper: human-ACHE |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 7AIY Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 7AIY Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 7AIY Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 7AIY 3D, interactive encyclopedia of proteins - PROTEOPEDIA server