| Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812 |
| Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 64 :812 , 2021 |
| Abstract : |
| PubMedSearch : Viayna_2021_J.Med.Chem_64_812 |
| PubMedID: 33356266 |
| Gene_locus related to this paper: human-ACHE |
| Title : Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AbetaPPswe\/PS-1 Mice of Different Ages - Serrano_2016_Curr.Alzheimer.Res_13_1017 |
| Author(s) : Serrano FG , Tapia-Rojas C , Carvajal FJ , Cisternas P , Viayna E , Sola I , Munoz-Torrero D , Inestrosa NC |
| Ref : Curr Alzheimer Res , 13 :1017 , 2016 |
| Abstract : |
| PubMedSearch : Serrano_2016_Curr.Alzheimer.Res_13_1017 |
| PubMedID: 26502813 |
| Title : 3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae - Verma_2015_Bioorg.Med.Chem_23_1321 |
| Author(s) : Verma A , Wong DM , Islam R , Tong F , Ghavami M , Mutunga JM , Slebodnick C , Li J , Viayna E , Lam PC , Totrov MM , Bloomquist JR , Carlier PR |
| Ref : Bioorganic & Medicinal Chemistry , 23 :1321 , 2015 |
| Abstract : |
| PubMedSearch : Verma_2015_Bioorg.Med.Chem_23_1321 |
| PubMedID: 25684426 |
| Title : Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity - Di Pietro_2015_Eur.J.Med.Chem_105_120 |
| Author(s) : Di Pietro O , Vicente-Garcia E , Taylor MC , Berenguer D , Viayna E , Lanzoni A , Sola I , Sayago H , Riera C , Fisa R , Clos MV , Perez B , Kelly JM , Lavilla R , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 105 :120 , 2015 |
| Abstract : |
| PubMedSearch : Di Pietro_2015_Eur.J.Med.Chem_105_120 |
| PubMedID: 26479031 |
| Title : Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase - Camerino_2015_Bioorg.Med.Chem.Lett_25_4405 |
| Author(s) : Camerino E , Wong DM , Tong F , Korber F , Gross AD , Islam R , Viayna E , Mutunga JM , Li J , Totrov MM , Bloomquist JR , Carlier PR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :4405 , 2015 |
| Abstract : |
| PubMedSearch : Camerino_2015_Bioorg.Med.Chem.Lett_25_4405 |
| PubMedID: 26386602 |
| Title : Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity - Sola_2015_Bioorg.Med.Chem_23_5156 |
| Author(s) : Sola I , Castella S , Viayna E , Galdeano C , Taylor MC , Gbedema SY , Perez B , Clos MV , Jones DC , Fairlamb AH , Wright CW , Kelly JM , Munoz-Torrero D |
| Ref : Bioorganic & Medicinal Chemistry , 23 :5156 , 2015 |
| Abstract : |
| PubMedSearch : Sola_2015_Bioorg.Med.Chem_23_5156 |
| PubMedID: 25678015 |
| Title : Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with beta-amyloid and tau anti-aggregating properties - Perez-Areales_2014_Bioorg.Med.Chem_22_5298 |
| Author(s) : Perez-Areales FJ , Di Pietro O , Espargaro A , Vallverdu-Queralt A , Galdeano C , Ragusa IM , Viayna E , Guillou C , Clos MV , Perez B , Sabate R , Lamuela-Raventos RM , Luque FJ , Munoz-Torrero D |
| Ref : Bioorganic & Medicinal Chemistry , 22 :5298 , 2014 |
| Abstract : |
| PubMedSearch : Perez-Areales_2014_Bioorg.Med.Chem_22_5298 |
| PubMedID: 25156301 |
| Title : Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents - Viayna_2014_J.Med.Chem_57_2549 |
| Author(s) : Viayna E , Sola I , Bartolini M , De Simone A , Tapia-Rojas C , Serrano FG , Sabate R , Juarez-Jimenez J , Perez B , Luque FJ , Andrisano V , Clos MV , Inestrosa NC , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 57 :2549 , 2014 |
| Abstract : |
| PubMedSearch : Viayna_2014_J.Med.Chem_57_2549 |
| PubMedID: 24568372 |
| Title : 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies - Di Pietro_2013_Eur.J.Med.Chem_73C_141 |
| Author(s) : Di Pietro O , Viayna E , Vicente-Garcia E , Bartolini M , Ramon R , Juarez-Jimenez J , Clos MV , Perez B , Andrisano V , Luque FJ , Lavilla R , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 73C :141 , 2013 |
| Abstract : |
| PubMedSearch : Di Pietro_2013_Eur.J.Med.Chem_73C_141 |
| PubMedID: 24389509 |
| Title : Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases - Galdeano_2012_J.Med.Chem_55_661 |
| Author(s) : Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV , Relat J , Ratia M , Bartolini M , Mancini F , Andrisano V , Salmona M , Minguillon C , Gonzalez-Munoz GC , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 55 :661 , 2012 |
| Abstract : |
| PubMedSearch : Galdeano_2012_J.Med.Chem_55_661 |
| PubMedID: 22185619 |
| Title : Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents - Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| Author(s) : Munoz-Torrero D , Pera M , Relat J , Ratia M , Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV |
| Ref : Neurodegener Dis , 10 :96 , 2012 |
| Abstract : |
| PubMedSearch : Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| PubMedID: 22236498 |
| Title : Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents - Galdeano_2010_Curr.Pharm.Des_16_2818 |
| Author(s) : Galdeano C , Viayna E , Arroyo P , Bidon-Chanal A , Blas JR , Munoz-Torrero D , Luque FJ |
| Ref : Curr Pharm Des , 16 :2818 , 2010 |
| Abstract : |
| PubMedSearch : Galdeano_2010_Curr.Pharm.Des_16_2818 |
| PubMedID: 20698824 |
| Title : Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates - Camps_2010_Chem.Biol.Interact_187_411 |
| Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Ramirez L , Viayna E , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Bidon-Chanal A , Huertas O , Dafni T , Luque FJ |
| Ref : Chemico-Biological Interactions , 187 :411 , 2010 |
| Abstract : |
| PubMedSearch : Camps_2010_Chem.Biol.Interact_187_411 |
| PubMedID: 20167211 |
| Title : Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates - Viayna_2010_ChemMedChem_5_1855 |
| Author(s) : Viayna E , Gomez T , Galdeano C , Ramirez L , Ratia M , Badia A , Clos MV , Verdaguer E , Junyent F , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Camps P , Munoz-Torrero D |
| Ref : ChemMedChem , 5 :1855 , 2010 |
| Abstract : |
| PubMedSearch : Viayna_2010_ChemMedChem_5_1855 |
| PubMedID: 20859987 |
| Title : Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation - Camps_2008_J.Med.Chem_51_3588 |
| Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Scarpellini M , Viayna E , Badia A , Clos MV , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Estelrich J , Lizondo M , Bidon-Chanal A , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 51 :3588 , 2008 |
| Abstract : |
| PubMedSearch : Camps_2008_J.Med.Chem_51_3588 |
| PubMedID: 18517184 |