Meperidine

General

Type : Piperidine, Opioid analgesic, Drug, Not A\/B H target

Chemical_Nomenclature : ethyl 1-methyl-4-phenylpiperidine-4-carboxylate

Canonical SMILES : CCOC(=O)C1(CCN(CC1)C)C2=CC=CC=C2

InChI : InChI=1S\/C15H21NO2\/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13\/h4-8H,3,9-12H2,1-2H3

InChIKey : XADCESSVHJOZHK-UHFFFAOYSA-N

Other name(s) : Demerol  ||  Pethidine  ||  Meperidine hydrochloride  ||  Meperidine  ||  Isonipecaine  ||  Lidol  ||  Pethanol  ||  Piridosal  ||  Algil  ||  Alodan  ||  Centralgin  ||  Dispadol  ||  Dolantin  ||  Mialgin  ||  Petidin Dolargan  ||  Dolestine  ||  Dolosal  ||  Dolsin  ||  Mefedina


MW : 247.33

Formula : C15H21NO2

CAS_number : 57-42-1

PubChem : 4058

UniChem : XADCESSVHJOZHK-UHFFFAOYSA-N

Wikipedia : Pethidine

Target

References (7)

Title : Selective inhibition of carboxylesterases by isatins, indole-2,3-diones - Hyatt_2007_J.Med.Chem_50_1876
Author(s) : Hyatt JL , Moak T , Hatfield MJ , Tsurkan L , Edwards CC , Wierdl M , Danks MK , Wadkins RM , Potter PM
Ref : Journal of Medicinal Chemistry , 50 :1876 , 2007
Abstract :
PubMedSearch : Hyatt_2007_J.Med.Chem_50_1876
PubMedID: 17378546

Title : Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1 - Zhang_1999_J.Pharmacol.Exp.Ther_290_314
Author(s) : Zhang J , Burnell JC , Dumaual N , Bosron WF
Ref : Journal of Pharmacology & Experimental Therapeutics , 290 :314 , 1999
Abstract :
PubMedSearch : Zhang_1999_J.Pharmacol.Exp.Ther_290_314
PubMedID: 10381793

Title : Meperidine and alfentanil do not reduce the gain or maximum intensity of shivering - Ikeda_1998_Anesthesiology_88_858
Author(s) : Ikeda T , Sessler DI , Tayefeh F , Negishi C , Turakhia M , Marder D , Bjorksten AR , Larson MD
Ref : Anesthesiology , 88 :858 , 1998
Abstract :
PubMedSearch : Ikeda_1998_Anesthesiology_88_858
PubMedID: 9579492

Title : Meperidine-induced generalized seizures with normal renal function - Marinella_1997_South.Med.J_90_556
Author(s) : Marinella MA
Ref : South Med J , 90 :556 , 1997
Abstract :
PubMedSearch : Marinella_1997_South.Med.J_90_556
PubMedID: 9160082

Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35
Author(s) : Lockridge O
Ref : Pharmacol Ther , 47 :35 , 1990
Abstract :
PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35
PubMedID: 2195556
Gene_locus related to this paper: human-BCHE

Title : Differential inhibition of plasma cholinesterase variants using the dibutyrate analogue of pancuronium bromide - Whittaker_1981_Hum.Hered_31_242
Author(s) : Whittaker M , Britten JJ
Ref : Hum Hered , 31 :242 , 1981
Abstract :
PubMedSearch : Whittaker_1981_Hum.Hered_31_242
PubMedID: 7287015

Title : The activity of various esterase inhibitors towards atypical human serum cholinesterase -
Author(s) : Kalow W , Davies R0
Ref : Biochemical Pharmacology , 1 :183 , 1958
PubMedID: